Clinical Trial To Determine The Effects Of Statins On Cognition: STAREE-Mind
Funder
National Health and Medical Research Council
Funding Amount
$2,795,199.00
Summary
Statins may improve brain health in older individuals but there is need for a large randomised trial to directly address this important question. This study of 10,000 community dwelling older individuals aged 70 years and over will provide crucial, high quality evidence on the effects of statins on cognitive function and dementia.
The long-term side effects of renal denervation are unknown. This project is designed to (1) investigate the potential atherosclerosis-promoting effect of renal denervation, and (2) to study the effectiveness of anti-inflammatory drugs to minimize this potential side effect. Ultimately, this project may improve the beneficial effects and minimize the potential side effects of renal denervation by routinely treating renal denervated patients with anti-inflammatory drugs.
Affordable And Scaleable New Strategies For Cardiovascular Disease Control
Funder
National Health and Medical Research Council
Funding Amount
$609,384.00
Summary
This Fellowship will support Professor Anthony Rodgers to continue a track record of excellence in health research, public-private partnerships and innovation. He has led landmark cardiovascular trials and was Principal Author of the WHO World Health Report. He plans a program of research on new combination cardiovascular medicines ('polypills'). Polypill trials that Professor Rodgers initiated have recently shown improved clinical outcomes, patient acceptability, quality of life and cost saving ....This Fellowship will support Professor Anthony Rodgers to continue a track record of excellence in health research, public-private partnerships and innovation. He has led landmark cardiovascular trials and was Principal Author of the WHO World Health Report. He plans a program of research on new combination cardiovascular medicines ('polypills'). Polypill trials that Professor Rodgers initiated have recently shown improved clinical outcomes, patient acceptability, quality of life and cost savings.Read moreRead less
The Role Of New Generation Multidetector Row CT For Identification And Management Of Vulnerable Plaque At Risk Of Acute Coronary Syndrome : A Prospective Observational And Interventional Study
Funder
National Health and Medical Research Council
Funding Amount
$189,326.00
Summary
Heart attack remains one of the major cause of death. This is usually due to rupture of a plaque (due to cholesterol buildup) in the major heart arteries. Studies using invasive ultrasound have identified some features of plaque that are at high risk of rupture. These plaques are referred to as "vulnerable plaque". Recent developments in the computed tomography (CT) technology which is a non-invasive technique has enabled us to also identify these features. However thus far, no prospective large
Improving The Prevention, Treatment And Management Of Cardiovascular & Chronic Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The identification, prevention and management of cardiovascular and chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises modern epidemiological research methods involving large scale clinical trials, registries and epidemiological modelling to advance our understanding and provide new directions for cardiovascular disease prevention and management.
A Study Of Statins For Reducing Events In The Elderly
Funder
National Health and Medical Research Council
Funding Amount
$5,372,965.00
Summary
Statins prevent heart attacks and strokes in people who have already experienced one or are at high risk. Statins are thought to do this by lowering cholesterol levels and improving the function of blood vessels. It is not known whether people 75 years or over should receive this therapy, as past studies have not included older people because they are more likely to suffer from drug side effects. This study will investigate the benefits versus risks of statins in healthy elderly people.
Pre-clinical Assessment Of The Therapeutic Potential Of Targeting The Hippo Pathway In Muscle Wasting & Muscle-derived Cancer
Funder
National Health and Medical Research Council
Funding Amount
$621,979.00
Summary
Recent findings have identified the Hippo signalling pathway as an important regulator of processes in muscle fibres and muscle progenitor cells. This project will look at the significance of the Hippo pathway in the development of muscle wasting caused by statin administration, and in the genesis of muscle derived tumors (rhabdomyosarcoma). The studies will determine if interventions that regulate the Hippo pathway could provide new therapies for these important muscle-related diseases.
Intervention To Reduce The Risk Of Diabetic Retinopathy And Early Adverse Retinal Changes In Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$1,294,846.00
Summary
The long term effects of young onset T1D may be devastating: diabetes is the leading cause of visual loss in young adults in Australia and other countries. We have the unique opportunity to investigate whether ACEI and statins will modify retinopathy through our collaboration with an already funded international multicentre trial. This study will treat adolescents for 4 years and will follow them for the next 5-10 years. We will use novel measures of retinal blood vessels size and fractals.
Does Statin Use Have A Disease Modifying Effect In Symptomatic Knee Osteoarthritis?
Funder
National Health and Medical Research Council
Funding Amount
$133,194.00
Summary
Osteoarthritis (OA) is a major cause of knee pain and disability. Treatments are limited to reducing pain and improving function: no therapy slows disease progression, with symptomatic end-stage OA treated by knee replacement. Statins, a drug class used to lower cholesterol levels, may affect the structural progression in knee OA. We propose a randomised controlled trial to see if statin use slows the progression of knee OA, which would delay or prevent the need for joint replacement.