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Evidence-driven Strategies To Reduce The Burden Of Infections Among Indigenous Children
Funder
National Health and Medical Research Council
Funding Amount
$267,859.00
Summary
Dr Asha Bowen will be building the evidence to reduce the burden of infectious diseases in Australia's Indigenous children during her early career fellowship. This will include a randomised controlled trial on the treatment of acute gastroenteritis in the Northern Territory and developing new strategies to reduce the burden of skin infections in children living in remote communities.
Scabies Mite Proteins As Targets For The Development Of New Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Scabies and associated bacteria disease (pyoderma) are a significant health burden, with pyoderma implicated in rheumatic fever and heart disease. Investigations of the mechanism underlying scabies and bacteria disease links, identified scabies proteins inhibiting the human complement system. The inhibition prevents mite damage and promotes growth of bacteria. This proposal aims to elucidate the interaction between scabies, bacteria and the human host, in order to design new therapeutics.
Improving Outcomes Of Severe Bacterial Infections In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$217,274.00
Summary
Severe infections such as pneumonia can cause failure of vital organs (severe sepsis) and subsequent death. 30-40% of people who develop severe sepsis die, even with the best modern therapies. Sepsis is five times more common in northern Australia than elsewhere. In this program of research, we plan to test new therapies for sepsis; to determine the causes of and risk factors for severe pneumonia in northern Australia; and to use this information to inform new guidelines for the management of se ....Severe infections such as pneumonia can cause failure of vital organs (severe sepsis) and subsequent death. 30-40% of people who develop severe sepsis die, even with the best modern therapies. Sepsis is five times more common in northern Australia than elsewhere. In this program of research, we plan to test new therapies for sepsis; to determine the causes of and risk factors for severe pneumonia in northern Australia; and to use this information to inform new guidelines for the management of sepsis and pneumonia in northern Australia.Read moreRead less
Understanding The Complex Relationship Between Host, Pathogen And Antibiotic Factors On Treatment Outcome In Serious Bacterial Infections
Funder
National Health and Medical Research Council
Funding Amount
$380,945.00
Summary
Millions of people still die every year from bacterial infections despite the availability of antibiotics. The same bacterial infection in one person can behave very differently in another person, so infections can range from trivial to life-threatening or fatal. Understanding the relationship between the patient, the infecting bacteria and the antibiotic treatment given will ultimately help to predict and improve outcomes for patients with serious bacterial infections.
The Development Of Novel Antibody Constructs And Peptides To Prevent Pathogenic Modulation Of The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$335,825.00
Summary
The current lack of effective vaccines, as well as the emergence of drug resistance, underpins the need for the development of novel therapeutics to treat bacterial infections and malaria. In this project, I will be using computer-based molecular modelling techniques to design novel antimicrobial treatments.