Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989759
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Australian Access to and Operation of Advanced Synchrotron Radiation Facilities at the Photon Factory. The primary national benefit of this application will be continued access by peer review for Australian scientists to the advanced synchrotron-radiation capabilities of the Australian National Beamline Facility and other complementary beamlines at the Photon Factory, Japan. This proposal is consistent with the National Research Priorities of An Environmentally Sustainable Australia, Promoting a ....Australian Access to and Operation of Advanced Synchrotron Radiation Facilities at the Photon Factory. The primary national benefit of this application will be continued access by peer review for Australian scientists to the advanced synchrotron-radiation capabilities of the Australian National Beamline Facility and other complementary beamlines at the Photon Factory, Japan. This proposal is consistent with the National Research Priorities of An Environmentally Sustainable Australia, Promoting and Maintaining Good Health and Frontier Technologies for Building and Transforming Australian Industries and will generate science to support and stimulate domestic industry, enhance the domestic knowledge base and international research profile, train students and future synchrotron scientists and foster domestic and international collaborations.Read moreRead less
The Language of Knowledge. Knowledge is central to our lives. The way we attribute knowledge to others governs whom we trust, how we reason, what we do, and whether we succeed. The significance of this project consists in a deeper understanding of our attributions of knowledge, situated within the context of questions. This project offers the benefits of quality foundational research in an interdisciplinary venue. It connects to a range of areas of National Research Priority including An Environ ....The Language of Knowledge. Knowledge is central to our lives. The way we attribute knowledge to others governs whom we trust, how we reason, what we do, and whether we succeed. The significance of this project consists in a deeper understanding of our attributions of knowledge, situated within the context of questions. This project offers the benefits of quality foundational research in an interdisciplinary venue. It connects to a range of areas of National Research Priority including An Environmentally Sustainable Australia, Promoting and Managing Good Health, and Frontier Technologies for Building and Transforming Australian Industries, insofar as all of these areas of National Research Priority are concerned with the acquisition and transfer of knowledge.Read moreRead less
Protein degradation in mammals. One mechanism by which the regulation of protein turnover occurs is the balance between the activity of enzymes responsible for the ubiquitination and deubiquitination of target proteins. The majority of targets of this second family of enzymes are unknown. This project proposes a method for the identification of the targets of two specific mammalian deubiquitinating enzymes in order to understand their function and to begin to explore this new research field. ....Protein degradation in mammals. One mechanism by which the regulation of protein turnover occurs is the balance between the activity of enzymes responsible for the ubiquitination and deubiquitination of target proteins. The majority of targets of this second family of enzymes are unknown. This project proposes a method for the identification of the targets of two specific mammalian deubiquitinating enzymes in order to understand their function and to begin to explore this new research field. Knowledge about this new aspect of protein degradation could provide a powerful tool to test the effect of the stabilisation or removal of specific proteins in the cell and also to develop new technologies in protein production.Read moreRead less
Mimetics and small chemical compounds for hemopoietic stem cell mobilisation. This project will result in the design and synthesis of new chemical compounds that could be used clinically to help collect blood stem cells for bone marrow transplantation. For patients this will mean more effective and less painful ways to collect stem cells and better transplant outcomes. There is a large, ongoing international market for this type of drug and likelihood of significant financial benefit.
Perception, interpretation, and the explanation of delusional beliefs. The occurrence of bizarrely false beliefs, called delusions, presents challenges, not only for clinical psychiatric practice, but also for psychology, neuroscience, and philosophy. The aim of this project is to make a distinctively philosophical contribution to our understanding of delusional beliefs by addressing three philosophical questions raised by the study of delusions, questions about perception, interpretation, and e ....Perception, interpretation, and the explanation of delusional beliefs. The occurrence of bizarrely false beliefs, called delusions, presents challenges, not only for clinical psychiatric practice, but also for psychology, neuroscience, and philosophy. The aim of this project is to make a distinctively philosophical contribution to our understanding of delusional beliefs by addressing three philosophical questions raised by the study of delusions, questions about perception, interpretation, and explanation. Answers to these questions will constitute substantial contributions to three central areas of philosophy, but their significance also extends beyond philosophy. They will impact on the scientific investigation of delusions and will contribute indirectly to the treatment and rehabilitation of sufferers.
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Epistemic Warrant: Transmission Failure, Basic Knowledge, and Entitlement. This Project will bring substantial intellectual, cultural, and economic benefits to the nation - not only by increasing research strength, contributing to research output and establishing an international research partnership, but also by deepening the relationship between the study of the mind and theory of knowledge as a traditional area within philosophy and thus helping to maintain the pivotal position of philosophy ....Epistemic Warrant: Transmission Failure, Basic Knowledge, and Entitlement. This Project will bring substantial intellectual, cultural, and economic benefits to the nation - not only by increasing research strength, contributing to research output and establishing an international research partnership, but also by deepening the relationship between the study of the mind and theory of knowledge as a traditional area within philosophy and thus helping to maintain the pivotal position of philosophy in our intellectual life. Students, early-career researchers and established philosophers will benefit from access to the intellectual and institutional resources of international partner universities and there will be substantial and quantifiable financial contributions by international universities and research agencies.Read moreRead less
Evolvability and the Evolution of Complexity. Anyone engaging in a moment's reflection on the striking richness, diversity, and complexity of the biological world is faced with the question: how did it get here? Though natural selection is central to answering this question, important new work has identified various conditions that make some lineages of organisms "evolvable": capable of changing in ways that radically expand the range of further possible changes. This project will clarify and in ....Evolvability and the Evolution of Complexity. Anyone engaging in a moment's reflection on the striking richness, diversity, and complexity of the biological world is faced with the question: how did it get here? Though natural selection is central to answering this question, important new work has identified various conditions that make some lineages of organisms "evolvable": capable of changing in ways that radically expand the range of further possible changes. This project will clarify and integrate these various conditions using empirical examples and simple models. The resulting work from this project will provide a clearer general understanding of what biological complexity is, and how science has compelling candidates for understanding how it evolves.Read moreRead less
Reasons and Rationality. The project explains how we assess the truth and falsehood of everyday claims about what people have reason to do. It also explains what legitimizes our practice of praising and blaming people for their success and failure at doing what we think they have reason to do. In so doing it provides a foundation for both our ordinary practice of holding people responsible, and for the more institutionalised counterpart of this ordinary practice in the law.
Understanding phenomenal experience as a natural part of our world. The natural sciences?physics, chemistry and biology?provide compelling accounts of our world. They contain, however, no overt mention of mental states and in particular the mental states with a phenomenology: states like itches and colour experiences. The challenge for naturalists is locate these states within the naturalist picture. This project develops and draws on representationalist accounts of mind to explain how to locate ....Understanding phenomenal experience as a natural part of our world. The natural sciences?physics, chemistry and biology?provide compelling accounts of our world. They contain, however, no overt mention of mental states and in particular the mental states with a phenomenology: states like itches and colour experiences. The challenge for naturalists is locate these states within the naturalist picture. This project develops and draws on representationalist accounts of mind to explain how to locate mental states that have a phenomenology within the naturalist's picture. This will yield new perspectives on the mental lives of machines.Read moreRead less
Conscious Experience and the Hegemony of Representation. Many things make humans special but three stand out: the possession of a moral sense, rationality, and consciousness. This project aims to explain consciousness in a way fully comppatible with the aspirations of cognitive science to see humans as a natural part of the physical world.