Understanding And Predicting Freezing Of Gait In Parkinson's Disease.
Funder
National Health and Medical Research Council
Funding Amount
$380,580.00
Summary
Freezing of Gait (FOG) affects half of all patients with Parkinson’s Disease (PD) with episodes causing the feet to feel glued to the ground leading to a significant falls risk. The mechanisms underlying FOG are not well understood and current treatments are usually ineffective. Combining brain wave recording, eye-tracking and functional brain scanning we will identify the changes that precipitate an episode of FOG allowing the development of a non-invasive device to prevent falls.
Matching Oars to Rowers. This project combines expert oar design, manufacture and advanced biomechanical analysis to produce new oar designs that match rowers? power generation characteristics with boat propulsion requirements. The outcome will be optimally configured oar designs that combine properties which maximise rowers? performance. The performance of the oar-rower combination will be race condition assessed, on-water, in a state-of-the-art measurement boat and an iterative process used to ....Matching Oars to Rowers. This project combines expert oar design, manufacture and advanced biomechanical analysis to produce new oar designs that match rowers? power generation characteristics with boat propulsion requirements. The outcome will be optimally configured oar designs that combine properties which maximise rowers? performance. The performance of the oar-rower combination will be race condition assessed, on-water, in a state-of-the-art measurement boat and an iterative process used to bring the oars to their final configurations. A range of specifications will result from matching the oar to different body types with emphasis on appropriate designs for women rowers.Read moreRead less
Bringing the boat into the lab: Rowing simulation. Rowing simulators are used for rowing training, rowing assessment and exercise. Their effectiveness for the first two depends on their exercise stimulus specificity to on-water rowing. Rowing simulators are also used in the fitness industry for exercise and in all applications the potential for injury should be minimised. This research will produce a "specification" of on-water rowing by characterising the magnitude and timing of the forces and ....Bringing the boat into the lab: Rowing simulation. Rowing simulators are used for rowing training, rowing assessment and exercise. Their effectiveness for the first two depends on their exercise stimulus specificity to on-water rowing. Rowing simulators are also used in the fitness industry for exercise and in all applications the potential for injury should be minimised. This research will produce a "specification" of on-water rowing by characterising the magnitude and timing of the forces and moments experienced on-water. Rowing simulator agreement with this specification will be tested, modifications suggested for their improvement, and one modified and retested. Simulator rowing will be computer-modelled and the potential for injury assessed.Read moreRead less
Passive mechanical properties of human muscles. Australia has a strong record in the discipline of biomechanics. The proposed studies will help maintain Australia's standing in the discipline. They will provide fundamental new data on the properties of human muscles and basic insights into muscle growth and adaptation. The data will be used to develop more refined biomechanical models than is currently possible. The studies will also provide training in world-leading research methods for two PhD ....Passive mechanical properties of human muscles. Australia has a strong record in the discipline of biomechanics. The proposed studies will help maintain Australia's standing in the discipline. They will provide fundamental new data on the properties of human muscles and basic insights into muscle growth and adaptation. The data will be used to develop more refined biomechanical models than is currently possible. The studies will also provide training in world-leading research methods for two PhD students and a research associate.Read moreRead less
Transient Tissue ‘priming’ Via FAK Inhibition To Impair Pancreatic Cancer Progression And Improve Sensitivity To Gemcitabine/Abraxane
Funder
National Health and Medical Research Council
Funding Amount
$643,848.00
Summary
The success of cancer drugs is dependent on many factors including the properties of the tumour tissue. As a tumour grows it changes the tissue around it, and this affects response to treatment. Combining classical biology with engineering to generate 3D models that mimic tumours, along with cutting-edge imaging technology and mouse models, we will target FAK-controlled cancer cell pathways that sense tissue changes, together with already approved cancer drugs to improve patient outcome.
Measuring large deformation tissue mechanical behaviour in living humans. This project aims to develop new in vivo imaging methods to characterise the nonlinear mechanical behaviour of soft biological tissues, and use them to measure the properties of muscle, liver and adipose tissue in human subjects. Comprehensively characterising the mechanical properties of an individual person’s body tissues in vivo is a long-standing challenge in biomechanics and biomedical engineering. These new methods a ....Measuring large deformation tissue mechanical behaviour in living humans. This project aims to develop new in vivo imaging methods to characterise the nonlinear mechanical behaviour of soft biological tissues, and use them to measure the properties of muscle, liver and adipose tissue in human subjects. Comprehensively characterising the mechanical properties of an individual person’s body tissues in vivo is a long-standing challenge in biomechanics and biomedical engineering. These new methods aim to overcome major imitations of current biomechanical imaging methods, and make new measurements of the nonlinear mechanical properties of muscle, liver and adipose tissues. These techniques may be useful for future diagnostic, biomechanics and mechanobiology applications.Read moreRead less
Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon durin ....Intelligent training (iTraining) for the human Achilles tendon. The project aims to improve understanding of the mechanical environment of the Achilles tendon. The Achilles tendon plays a crucial role in human motor function and is also a structure that is commonly injured and notoriously difficult to treat. A major barrier to improving Achilles tendon function, preventing tendon injury and enhancing tendon repair is a poor understanding of the mechanical environment of the Achilles tendon during training and rehabilitation. The project aims to develop a better understanding of the loading conditions that optimise tendon metabolism. Based on this, it then intends to develop new technologies to estimate the mechanical behaviour of the human Achilles tendon in real time based on integrated use of wearable technology, and new training guidelines that will optimise human tendon adaptation.Read moreRead less
Protecting Occupants in Vehicle Rollover Crashes. This project addresses a public health issue involving rollover crashes. It will help prevent 340 deaths, 6000 injuries and save $3.6 billion annually in Australia and many fold this number internationally. A dynamic rollover crashworthiness test protocol, that ensures efficient and economical vehicle rollover protection systems are designed and manufactured, will be provided to consumer and regulatory bodies to consider and implement. In additio ....Protecting Occupants in Vehicle Rollover Crashes. This project addresses a public health issue involving rollover crashes. It will help prevent 340 deaths, 6000 injuries and save $3.6 billion annually in Australia and many fold this number internationally. A dynamic rollover crashworthiness test protocol, that ensures efficient and economical vehicle rollover protection systems are designed and manufactured, will be provided to consumer and regulatory bodies to consider and implement. In addition, much needed Occupational Health & Safety information regarding vehicle rollover crashworthiness, which provide a safe work place environment for professional drivers and employees using vehicles, will be supplied to industry fleet managers, defence and emergency services.Read moreRead less
Evaluating the impact of obesity on knee load over time in those who have undergone optimal surgical re-alignment after total knee replacement . This project investigates the impact of obesity on alignment and knee load over time in those who have undergone total knee replacement. This information is critical for understanding whether obesity results in increasing knee load after surgery which can lead to more rapid wearing of the knee surfaces and an earlier need for revision surgery.
Foot-down not ground-up: moving from splint to natural models for children's shoe design. We will provide much-needed knowledge of the impact of children's footwear on their musculoskeletal development, by conducting rigorous experimental comparisons of a standard school shoe, a custom-built 'midfoot flexing' shoe, bare feet, and a new school shoe design concept developed by university researchers to enhance rather than disrupt natural foot function. The innovation will make Bata Australia the f ....Foot-down not ground-up: moving from splint to natural models for children's shoe design. We will provide much-needed knowledge of the impact of children's footwear on their musculoskeletal development, by conducting rigorous experimental comparisons of a standard school shoe, a custom-built 'midfoot flexing' shoe, bare feet, and a new school shoe design concept developed by university researchers to enhance rather than disrupt natural foot function. The innovation will make Bata Australia the first manufacturer to embrace evidence-based shoe design, and will be an opportunity for the Company to provide global leadership in the field. Our advances will inform health professionals, manufacturers and parents in the task of improving the musculoskeletal health of young Australians.Read moreRead less