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Translation Of Abdominal Functional Electrical Stimulation From A Research Tool To Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
People with a spinal cord injury to the neck are often unable to move their arms and legs, a condition known as tetraplegia. Tetraplegics are also unable to use their abdominal muscles, reducing breathing and bowel function. This project will use electrical pulses to make their abdominal muscles contract, improving breathing and bowel function. The results will be used to develop a program that can be used in all hospitals, reducing illness in tetraplegia and saving the health service money.
Unravelling The Riddle Of Spondylolysis: A Novel Biomechanical Approach Incorporating Innovative Strain Field Mapping, Acute Fracture Path Mapping And In Vivo Weightbearing Spinal Kinematics Derived From Open Magnetic Resonance Imaging.
Funder
National Health and Medical Research Council
Funding Amount
$334,673.00
Summary
Low back pain represents a significant social and economic burden in Australia and can be debilitating for individuals. This project aims to understand the biomechanical origins and consequences of spondylolysis, a common spinal stress fracture affecting both children and adults. The results of these studies will contribute to improved prevention, detection and treatment of this spinal condition, and reduce the incidence of more serious spinal problems which can occur subsequent to spondylolysis ....Low back pain represents a significant social and economic burden in Australia and can be debilitating for individuals. This project aims to understand the biomechanical origins and consequences of spondylolysis, a common spinal stress fracture affecting both children and adults. The results of these studies will contribute to improved prevention, detection and treatment of this spinal condition, and reduce the incidence of more serious spinal problems which can occur subsequent to spondylolysis.Read moreRead less
Tumor Targeted T Cells To Enhance Anti-tumor Efficacy And Dictate Umbilical Cord Blood (UCB) Engraftment In The Setting Of Double UCB Transplant.
Funder
National Health and Medical Research Council
Funding Amount
$376,002.00
Summary
Currently, despite cord blood transplantation, most leukemia patients will ultimately die of disease relapse. Therefore, my proposal is focused on improving the effectiveness of cord blood transplantation by further infusion of gene modified umbilical cord derived immune blood cells designed to specifically target and lyse residual leukemia tumor cells. This novel approach this will decrease disease relapse and lead to better patient survival following cord blood transplant therapy.
Disease Gene Discovery And Improved Genetic Diagnosis In Neuromuscular Disorders
Funder
National Health and Medical Research Council
Funding Amount
$473,321.00
Summary
Paediatric nerve and muscle disorders result in weakness, chronic disability and often early death. Over half of all affected children do not yet have a genetic diagnosis. This project will use advanced sequencing technology to increase genetic diagnosis rates and identify new disease-causing genes. This will result in improved patient care and a better understanding of the biological pathways altered by these disorders. It will also facilitate the identification of targets for future therapies.
The Potential Of Cord Blood Stem Cells To Reduce Neuroinflammation
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Cerebral palsy (CP) is the most common cause of physical disability in children and it is well recognised that the brain injury that underlies CP occurs during pregnancy or around the time of birth. Stem cells isolated from umbilical cord blood offer a promising new therapy for children with CP. This proposal will explore the mechanism of how cord blood stem cells can reduce brain inflammation and damage caused by hypoxia-ischemia, an event known to lead to cerebral palsy.
Maximising The Usefulness And Timeliness Of Trauma And Emergency Registry Data For Improving Patient Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
The aim of my fellowship will be to develop and evaluate the processes and technological applications to make trauma registry data useful, relevant and timely for informing the care of the injured patient real-time i.e. during their hospital stay. Better use of accessible quality data will lead to better interventions and a reduction in deaths and disability. I will be working with world leading trauma system and trauma registry experts and the Alfred Hospital.