Neural plasticity in older adult human vision. This project aims to expand our understanding of age related changes in brain function, specifically plasticity. The project will increase knowledge of the role of an inhibitory neurotransmitter GABA in visual plasticity. Expected outcomes include new knowledge regarding the regulation of brain function in adulthood, enabling future research and planning for societal benefit to older Australia.
Cognitive Foundations of Fast Decision Making. This project aims to develop a new theory of fast decision making. In all walks of life, from the sports field to the battlefield, fast and accurate decisions are central to human performance. This project will develop and test mathematical models of the processes involved in making decisions with continuous choice sets and decisions requiring integration of multiple sources of information and decisions in which information varies over time. It is e ....Cognitive Foundations of Fast Decision Making. This project aims to develop a new theory of fast decision making. In all walks of life, from the sports field to the battlefield, fast and accurate decisions are central to human performance. This project will develop and test mathematical models of the processes involved in making decisions with continuous choice sets and decisions requiring integration of multiple sources of information and decisions in which information varies over time. It is expected to contribute to our understanding of factors that characterise and limit human performance in settings in which fast and accurate decisions are required. It is expected to benefit the design of systems and environments in which safety and efficiency depend on human decision making.Read moreRead less
Using visual science to reduce the dangers of night driving. This project aims to develop novel tests of visual function relevant to the modern night driving environment. Night driving is challenging for all drivers and has been linked to poor visibility under low light conditions. This project will characterise the visual challenges of the modern night driving environment, develop visual tests that incorporate the dynamic light levels typical of night-time roads and assess the association of th ....Using visual science to reduce the dangers of night driving. This project aims to develop novel tests of visual function relevant to the modern night driving environment. Night driving is challenging for all drivers and has been linked to poor visibility under low light conditions. This project will characterise the visual challenges of the modern night driving environment, develop visual tests that incorporate the dynamic light levels typical of night-time roads and assess the association of these tests with night driving performance. The outcomes will contribute new knowledge regarding dynamic visual processing and the ageing visual system and will inform vision testing, potential interventions to improve visual function for night driving and reduce the dangers of night driving.Read moreRead less
Characterisation and Prevention of Vibration-Induced Drowsiness in Drivers. The present CIs have demonstrated that vibrational frequencies of 4-7 Hz entrain brainwaves associated with the onset of sleep. Our unpublished pilot data show that higher vibrational frequencies can restore alertness. Thus future vehicle design could dampen 3-8Hz vibrations while higher frequency vibrations could counteract drowsiness or stimulate alertness. This project aims to: i) develop novel equivalent drowsiness c ....Characterisation and Prevention of Vibration-Induced Drowsiness in Drivers. The present CIs have demonstrated that vibrational frequencies of 4-7 Hz entrain brainwaves associated with the onset of sleep. Our unpublished pilot data show that higher vibrational frequencies can restore alertness. Thus future vehicle design could dampen 3-8Hz vibrations while higher frequency vibrations could counteract drowsiness or stimulate alertness. This project aims to: i) develop novel equivalent drowsiness contours for the effects of physical vibration on driver drowsiness that will form the basis of a new industry standard for transportation safety; ii) develop an innovative vibration regime to improve alertness. This research will reduce transportation injuries and deaths by enabling the design of safer transport vehicles.Read moreRead less
Central Representation of Electroacoustic Stimuli. Cochlear implantation, initially only provided to profoundly deaf individuals, is now routine in people with substantial residual hearing. Although stimulation via a cochlear implant and hearing aid in the same ear has been shown to improve speech understanding, particularly in noise, and to increase the aesthetic quality of sound, almost nothing is known about the physiological mechanisms underlying these benefits. The broad aim of our project ....Central Representation of Electroacoustic Stimuli. Cochlear implantation, initially only provided to profoundly deaf individuals, is now routine in people with substantial residual hearing. Although stimulation via a cochlear implant and hearing aid in the same ear has been shown to improve speech understanding, particularly in noise, and to increase the aesthetic quality of sound, almost nothing is known about the physiological mechanisms underlying these benefits. The broad aim of our project is to address this deficiency by measuring the patterns of neural activity evoked by speech sounds across the tonotopic axis in the inferior colliculus and auditory cortex and assess the extent to which the pattern of neural activity allows discrimination between the different speech sounds.Read moreRead less
A statistical decision theory of cognitive capacity. This project aims to investigate the limited capacity of the human cognitive system to form representations of the things in the world around us and to make decisions about them in real time. Its goal is to provide an integrated theory of cognitive capacity based on the statistical properties of cognitive representations and the decision processes that act on them. Its expected outcome will be a unified metric for cognitive capacity that will ....A statistical decision theory of cognitive capacity. This project aims to investigate the limited capacity of the human cognitive system to form representations of the things in the world around us and to make decisions about them in real time. Its goal is to provide an integrated theory of cognitive capacity based on the statistical properties of cognitive representations and the decision processes that act on them. Its expected outcome will be a unified metric for cognitive capacity that will allow us to quantify how cognitive load affects the speed and accuracy of decision making. It will benefit the design and evaluation of high workload real-time decision systems and will contribute to the selection and training of users of such systems.
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Novel mechanisms for regulating the retinal vasculature. Tight control of the retinal vasculature is crucial for maintaining normal vision. Unlike most blood vessels in the body, those in the retina and brain receive no direct neural control. Rather they rely on support cells to communicate the needs of neurons. This project aims to examine the mechanisms by which resident immune cells, called microglia, regulate retinal capillaries in response to neural activity. New knowledge examining a novel ....Novel mechanisms for regulating the retinal vasculature. Tight control of the retinal vasculature is crucial for maintaining normal vision. Unlike most blood vessels in the body, those in the retina and brain receive no direct neural control. Rather they rely on support cells to communicate the needs of neurons. This project aims to examine the mechanisms by which resident immune cells, called microglia, regulate retinal capillaries in response to neural activity. New knowledge examining a novel mechanism will be generated. This information is crucial for enhancing our understanding of how blood vessels are controlled in the retina and brain and will guide the development of novel ways of examining blood vessel function.Read moreRead less
Ultra-low fouling active surfaces. This project aims to develop chemistries and fabrication approaches through innovative materials evaluation to develop ultra-low fouling active electrode surfaces. Development of ultra-low fouling surfaces will have significant impact in a range of applications where system or device failure is attributed to fouling. The growing field of bionics, where implantable electronic devices interface directly with the nervous system, is one such device. The expected ou ....Ultra-low fouling active surfaces. This project aims to develop chemistries and fabrication approaches through innovative materials evaluation to develop ultra-low fouling active electrode surfaces. Development of ultra-low fouling surfaces will have significant impact in a range of applications where system or device failure is attributed to fouling. The growing field of bionics, where implantable electronic devices interface directly with the nervous system, is one such device. The expected outcomes will be an understanding of the material requirements that lead to the elimination of protein and cell accumulation at surfaces that degrades the performance and lifetime of these implants. The findings will benefit any application where fouling is a problem.Read moreRead less
Neuronal origin of functional maps on the mammalian visual cortex. This project aims to study how the brain processes images. Basic features of objects in the visual scene seem to be coded on the visual cortex in an orderly way. By recording neurones’ electrical activity in a mammalian brain, this project aims to study how such organisation is determined at the neuronal level, namely how the individual nerves and synapses that form the brain and process the signals are organised to form the over ....Neuronal origin of functional maps on the mammalian visual cortex. This project aims to study how the brain processes images. Basic features of objects in the visual scene seem to be coded on the visual cortex in an orderly way. By recording neurones’ electrical activity in a mammalian brain, this project aims to study how such organisation is determined at the neuronal level, namely how the individual nerves and synapses that form the brain and process the signals are organised to form the overall functional architecture visible at a macroscopic level. This understanding could realise the basis of normal visual perception in robotic vision and brain-machine interfaces.Read moreRead less
The integration of perception and thought. This project aims to use a new neural marker to discover and conceptualise how the brain integrates perception with thought. Combining approaches from cognitive neuroscience and the philosophy of cognitive science, the project intends to show how cognitive performance in healthy individuals depends on the degree of integration of top-down and bottom-up signals in the brain. The expected outcome is new empirical and philosophical understanding of the con ....The integration of perception and thought. This project aims to use a new neural marker to discover and conceptualise how the brain integrates perception with thought. Combining approaches from cognitive neuroscience and the philosophy of cognitive science, the project intends to show how cognitive performance in healthy individuals depends on the degree of integration of top-down and bottom-up signals in the brain. The expected outcome is new empirical and philosophical understanding of the conditions for optimal integration of perception and thought, as well as enhanced interdisciplinary capacity and cross-institutional collaboration. The anticipated benefit is an accessible neuroimaging tool for cognitive assessment.Read moreRead less