Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to ....Molecular approaches to solving current and emerging problems in the epidemiology and diagnosis of Marek's disease in Australia. Marek's disease (MD) is a ubiquitous viral disease of chickens that is currently controlled in meat chickens by blanket vaccination of all chickens. However, as has happened overseas, the efficacy of the HVT vaccine being used in Australia is breaking down resulting in subclinical and clinical losses due to MD. To assist industry deal with this situation we propose to develop novel molecular methods for the quantification of Marek's disease viruses (MDV) in the host and the environment, to use these methods to design effective early monitoring systems for MD in broilers that predict disease and performance outcomes, and to develop an epidemiological model that will predict the spread and severity of MD as failure of vaccinal protection progresses.Read moreRead less
The biology and epidemiology of the grapevine canker fungi, Botryosphaeria sp. Decline and dieback of grapevines is becoming an increasing problem for the viticulture industry in NSW. Recently, species of the fungus Botryosphaeria, were isolated from grapevines exhibiting these symptoms. In order to understand the biology and epidemiology of the causal organisms, we aim to; (i) determine species of Botryosphaeria present in NSW vineyards; (ii) determine which species are pathogenic on grapevines ....The biology and epidemiology of the grapevine canker fungi, Botryosphaeria sp. Decline and dieback of grapevines is becoming an increasing problem for the viticulture industry in NSW. Recently, species of the fungus Botryosphaeria, were isolated from grapevines exhibiting these symptoms. In order to understand the biology and epidemiology of the causal organisms, we aim to; (i) determine species of Botryosphaeria present in NSW vineyards; (ii) determine which species are pathogenic on grapevines; (iii) characterise the genetic diversity of strains and; (iv) screen fungicides for the control of these fungi. Information on the species, their biology and pathogenicity on grapevines, will enable the development of appropriate management strategies for its control and may lead to the development of molecular tools to identify species of Botryosphaeria.Read moreRead less
New Approaches to the Control of Post-Weaning Diarrhoea in Piglets. In Australia, post?weaning diarrhoea (PWD) in piglets is a major constraint to efficient and profitable production. Increasing levels of resistance to dietary antibiotics by gut pathogens such as Escherichia coli, the bacterium implicated in PWD, is a major reason for this problem. This research will identify nutritional means of controlling PWD and increasing production after weaning. This will be achieved by strategic nutritio ....New Approaches to the Control of Post-Weaning Diarrhoea in Piglets. In Australia, post?weaning diarrhoea (PWD) in piglets is a major constraint to efficient and profitable production. Increasing levels of resistance to dietary antibiotics by gut pathogens such as Escherichia coli, the bacterium implicated in PWD, is a major reason for this problem. This research will identify nutritional means of controlling PWD and increasing production after weaning. This will be achieved by strategic nutritional interventions in the pre-weaning and (or) post-weaning periods targeted at reducing bacterial pathogens in the gut. A reduction in PWD will increase the overall efficiency of pig production in Australia and reduce antibiotic use.Read moreRead less
Practical application of gene silencing: is delivery of long double stranded ribonucleic acid (dsRNA) by plant cells efficient in conferring host resistance to parasitic nematodes? Nematode that attack plants cause $120 billion of crop losses worldwide. Chemicals used for their control are being phased out because of environmental concerns, and natural resistance is limited. The aim of this project is to use Australian IP to develop a new form of resistance to nematodes based on knowledge of th ....Practical application of gene silencing: is delivery of long double stranded ribonucleic acid (dsRNA) by plant cells efficient in conferring host resistance to parasitic nematodes? Nematode that attack plants cause $120 billion of crop losses worldwide. Chemicals used for their control are being phased out because of environmental concerns, and natural resistance is limited. The aim of this project is to use Australian IP to develop a new form of resistance to nematodes based on knowledge of the host-pathogen interactions. A successful outcome could contribute an additional 5-20% increase in crop yields (depending on the crop) through inherent resistance of crops to nematode pests. This would benefit rural communities and the national economy, and could also generate international royalties.Read moreRead less
Factors impacting on workplace retention in speech pathology. Retention of speech pathologists within their profession and within the public service is presenting a major problem for the professional association, the public service and service users. In repsonse to this situation our study aims to measure the psychological well being of speech pathologists nationally and to identify workplace dimensions that are hindering or enhancing retention. The results of this study will be of significance ....Factors impacting on workplace retention in speech pathology. Retention of speech pathologists within their profession and within the public service is presenting a major problem for the professional association, the public service and service users. In repsonse to this situation our study aims to measure the psychological well being of speech pathologists nationally and to identify workplace dimensions that are hindering or enhancing retention. The results of this study will be of significance to all stakeholders, in particularly individuals with communication disorders. The successful retention of experienced speech pathologists within the profession and the public sector will help ensure expert services are available to Australia's ageing population.Read moreRead less
Beyond Speech: Towards better communication for children with hearing loss. Despite the benefits of early newborn hearing screening and early intervention programs for children with hearing loss, most still experience academic and social challenges at school. This is partly due to ongoing listening effort, leading to communicative breakdown. This project aims to identify the locus of the communicative challenges these children face during daily discourse interactions. The outcomes will identify ....Beyond Speech: Towards better communication for children with hearing loss. Despite the benefits of early newborn hearing screening and early intervention programs for children with hearing loss, most still experience academic and social challenges at school. This is partly due to ongoing listening effort, leading to communicative breakdown. This project aims to identify the locus of the communicative challenges these children face during daily discourse interactions. The outcomes will identify which levels of language are most compromised and will inform future interventions to reduce children’s listening effort. This will be undertaken by bringing together researchers in basic science with hearing service providers, parents and industry, providing an innovative model for solving multidisciplinary challenges.Read moreRead less
Physiologically accurate audio processing in cochlear implants. This project proposes to use a physiologically motivated computational model of the cochlea, which along with newly developed cochlear-implant electrode technology will produce the next quantum improvement in speech intelligibility and quality of hearing for implant recipients.
Gene therapy to enhance auditory prosthesis performance for cochlear implants. The cochlear implant is the most effective neural prosthesis, restoring hearing to the deaf. The research aims to develop a new type of implant compatible with delivery of therapeutic genes to the cells lining the cochlea. Gene therapy DNA constructs will be developed that will enhance neural survival and growth, improving cochlear implant performance. The research will provide advances in understanding how to tran ....Gene therapy to enhance auditory prosthesis performance for cochlear implants. The cochlear implant is the most effective neural prosthesis, restoring hearing to the deaf. The research aims to develop a new type of implant compatible with delivery of therapeutic genes to the cells lining the cochlea. Gene therapy DNA constructs will be developed that will enhance neural survival and growth, improving cochlear implant performance. The research will provide advances in understanding how to transfer genes into cochlear tissue, as well as development of gene cassettes for effective neural repair. The work will advance the field of bionics, an area where Australia is establishing international preeminence.Read moreRead less
Captions for the Deaf and Hearing Impaired: Availability versus Accessibility. The availability of educational, informational and recreational services for deaf and hearing-impaired people has been dramatically facilitated by (i) increased television captioning due to the 2001 introduction of the Television Broadcasting Services Act; and (ii) trial introduction of real-time captioning in educational settings. These innovations must be matched by equally innovative ways of increasing the accessib ....Captions for the Deaf and Hearing Impaired: Availability versus Accessibility. The availability of educational, informational and recreational services for deaf and hearing-impaired people has been dramatically facilitated by (i) increased television captioning due to the 2001 introduction of the Television Broadcasting Services Act; and (ii) trial introduction of real-time captioning in educational settings. These innovations must be matched by equally innovative ways of increasing the accessibility of captions, which is currently limited by English literacy, caption speed, and caption reduction techniques. Here, systematic manipulation of these factors in experiments on television captioning with adults and educational captioning with children will determine how resources might best be directed to improving caption accessibility.Read moreRead less
Tonal language development in Mandarin and Cantonese-speaking children with cochlear implants. Cochlear implantation in children is expanding in countries where tonal languages are spoken, despite limited evidence of the effectiveness of implant use in these settings. This project will examine the impact of implant use on children's perception of tone, their production of speech and assesses how this affects functional communication.