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Communication And Swallowing Outcomes In Patients With Acquired And Progressive Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$426,556.00
Summary
We all talk, eat and drink, but it’s not until we lose these skills that we recognise their importance. Communication & swallowing disorders following from progressive brain disorders such as dementia and ataxia result in daily disadvantage through poor educational and employment outcomes & social isolation. These deficits make the evaluation, long term monitoring and treatment a critical element in disease management.
Epilepsy and speech disorders are common diseases in the Australian population that have major genetic contributions. To improve clinical care I will study our unique set of patients with epilepsies or speech impairments. Discovery of genes will provide new information that will improve diagnosis, treatment and counselling of patients and their families. This will enhance long established Australian clinical and research expertise in epilepsy and speech disorders.
This project aims to improve the acute treatment of children with burn injuries through developing more effective and novel treatments and understanding the conditions required for burn injuries to occur.
Neurodegenerative Disease Pathology, Mechanisms, Models And Treatments
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Frontotemporal dementia (FTD) and motor neuron disease (MND) are fatal and incurable neurodegenerative diseases. Although dissimilar in symptoms, most cases of both FTD and MND are characterised at autopsy by abnormal accumulations of the TDP-43 protein in neurons. In this fellowship, I will characterise the biochemical changes caused by TDP-43 malfunction that occur in both FTD and MND and test potential new therapeutics in mice, to identify new ways to treat these devastating diseases.