Biological determinants of the safety and stability of neuroprosthetic stimulation electrodes. Performance of cochlear implants and the quality of sound perceived by patients is strongly related to electrode impedance. Electrode impedance fluctuates relative to the implant electrical activity, but the mechanisms which cause this are not clear. This project aims to investigate the role of protein adsorption in electrode performance, including impedance and material dissolution. To enable these in ....Biological determinants of the safety and stability of neuroprosthetic stimulation electrodes. Performance of cochlear implants and the quality of sound perceived by patients is strongly related to electrode impedance. Electrode impedance fluctuates relative to the implant electrical activity, but the mechanisms which cause this are not clear. This project aims to investigate the role of protein adsorption in electrode performance, including impedance and material dissolution. To enable these investigations a new biomimetic analogue of the perilymph (cochlea fluid) is intended to be developed. Additionally, the project aims to investigate two strategies to minimise impedance changes: small pulse electrode cleaning and antifouling coatings. Understanding and control of factors influencing electrode stability aim to facilitate next-generation implant designs.Read moreRead less
Targeting electrical stimulation of neural tissue. This project aims to develop a platform of mathematical methods for targeting electrical stimulation of neural tissue. The proposed methods work by selecting the amplitude and polarity of each stimulating electrode in an array based on a desired pattern of neural activation. The algorithms are particularly applicable to high-density electrode arrays. The project will work with an Australian industry leader to provide significant benefits to Aust ....Targeting electrical stimulation of neural tissue. This project aims to develop a platform of mathematical methods for targeting electrical stimulation of neural tissue. The proposed methods work by selecting the amplitude and polarity of each stimulating electrode in an array based on a desired pattern of neural activation. The algorithms are particularly applicable to high-density electrode arrays. The project will work with an Australian industry leader to provide significant benefits to Australia’s high-tech sector through increased knowledge and capacity.Read moreRead less
Feedthrough technologies for polymeric encapsulated active implants. The project will address the scientific challenges of signal transfer between tissue and novel active implantable medical devices, with major implications for cochlear implant manufacture. This will lead to improvements in the quality of life of the hearing-impaired, and will make an important contribution to the development of other sensory implants.
Computational neural modelling of bottom-up information and top-down attention in auditory perception. The aim of this project is to gain a better understanding of the ways in which our auditory cortex functions. This project will make a significant contribution to this important and fundamental aspect of brain science and brain-inspired computation. The outcome will be to build a computational model of the auditory cortex, through simulation of the detailed neuronal responses using spiking neur ....Computational neural modelling of bottom-up information and top-down attention in auditory perception. The aim of this project is to gain a better understanding of the ways in which our auditory cortex functions. This project will make a significant contribution to this important and fundamental aspect of brain science and brain-inspired computation. The outcome will be to build a computational model of the auditory cortex, through simulation of the detailed neuronal responses using spiking neurons. Applications will develop improved processing strategies for automatic speech recognition, hearing aids, bionic ears (cochlear implants), robotics and other machine processing systems.Read moreRead less