Speaking my language: International speech acquisition in Australia. It is important to differentiate between children who have communication impairment (difficulty learning all languages) from those who only have difficulty learning subsequent language(s). Communication impairment in multilingual children is both undiagnosed and over-diagnosed due to lack of culturally-sensitive measurement tools. Early intervention can ameliorate communication impairment in children and can reduce subsequent e ....Speaking my language: International speech acquisition in Australia. It is important to differentiate between children who have communication impairment (difficulty learning all languages) from those who only have difficulty learning subsequent language(s). Communication impairment in multilingual children is both undiagnosed and over-diagnosed due to lack of culturally-sensitive measurement tools. Early intervention can ameliorate communication impairment in children and can reduce subsequent educational, social and occupational outcomes of untreated communication impairment. By working with people around the world, this Fellowship will result in the development of the International Speech Assessment designed to differentially identify children and to specify holistic early intervention goals.Read moreRead less
Involvement of the Human Retinal Endothelial Cell in Blinding Eye Disease. Endothelial cells line the blood vessels of the vascular networks that circulate blood through the tissues. The molecular constitution of each endothelial cell is different and specific to function, but may predispose to tissue-specific disease. Retinal endothelial cells ensure the nutrition and protection of a tissue critical to vision, but are key participants in retinal ischemic, inflammatory and infectious diseases th ....Involvement of the Human Retinal Endothelial Cell in Blinding Eye Disease. Endothelial cells line the blood vessels of the vascular networks that circulate blood through the tissues. The molecular constitution of each endothelial cell is different and specific to function, but may predispose to tissue-specific disease. Retinal endothelial cells ensure the nutrition and protection of a tissue critical to vision, but are key participants in retinal ischemic, inflammatory and infectious diseases that threaten vision. This project will investigate molecular activities of retinal endothelial cells that are relevant to retinal disease processes and explore future biological therapies directed against the human retinal endothelial cell that address efficacy and safety deficiencies of current treatments.Read moreRead less
Optimising how the brain processes language in healthy and neurological populations. This research will examine how the ability of the brain to process language can be modified by behavioural experiences, certain drugs and direct brain stimulation. The findings have the potential to reveal new ways to treat language disorders after brain injury or disease.
Illuminating the Language-specific and Physiological Motor-control Influences on Children's Production of Lexical Stress. Great progress has been made in understanding the production of individual speech sounds but much less is known about the production of prosody. Lexical stress is a type of prosody that reflects the contrast between strong and weak syllables within single words. The ability to achieve this contrastivity shows a protracted developmental trajectory in healthy children and is at ....Illuminating the Language-specific and Physiological Motor-control Influences on Children's Production of Lexical Stress. Great progress has been made in understanding the production of individual speech sounds but much less is known about the production of prosody. Lexical stress is a type of prosody that reflects the contrast between strong and weak syllables within single words. The ability to achieve this contrastivity shows a protracted developmental trajectory in healthy children and is atypical in some children with autism. How these developmental influences relate to language-specific versus physiological motor-control factors is unknown. This project will address this critical research problem via innovative acoustic investigations. Outcomes will trigger the next generation of speech production models with potential for impact in areas like speech pathology.Read moreRead less
Harnessing non-invasive brain stimulation to improve language function in healthy and pathological ageing. This project will examine how the ability of the ageing brain to process language can be improved by non-invasive brain stimulation. The findings have the potential to reveal new ways to treat language impairments in ageing-associated brain injury and disease.
Developing better treatments for language disorders. This project will enable better treatment of people with disorders affecting language such as aphasia, dyslexia, and dementia. It will achieve this through development of more detailed theories of language processing, better assessment of language disorders and a better understanding of how treatments for language disorders have their effects.
A new model of human speech production through computational modeling and human functional brain imaging. It is still largely a mystery how we convert our thoughts into fluent intelligible speech. This project will bring together experts in speech pathology, neuroscience, and computer modeling to create a new biologically-plausible model of speech production to advance understanding of speech development, ageing, and mechanisms of recovery after injury.
Testing the Modularity of Memory. Researchers disagree about whether verbal and visual working memory (WM) storage occurs in separate modules. Recent evidence suggests that only verbal memoranda have access to a specialised module, while visual memories make use of more general resources. This project aims to re-examine interference between verbal and visual memoranda using statistical methods specialised for assessing whether multiple latent factors underlie performance on recognition memory ta ....Testing the Modularity of Memory. Researchers disagree about whether verbal and visual working memory (WM) storage occurs in separate modules. Recent evidence suggests that only verbal memoranda have access to a specialised module, while visual memories make use of more general resources. This project aims to re-examine interference between verbal and visual memoranda using statistical methods specialised for assessing whether multiple latent factors underlie performance on recognition memory tasks, examining adult and child populations. This is expected to influence applications of WM theory in many everyday settings, resulting in improvements in educational practices, workplace procedures, and clinical treatments that depend on theoretical understandings of limits in cognition.Read moreRead less
Improved identification of patients 'at risk' of depression, and optimal targeting of rehabilitation post-stroke through novel brain imaging and biomarkers. Use of novel brain imaging and biomarkers for identification of stroke survivors at risk of depression and recurrent stroke will permit early access to preventative and effective treatments for depression and improve capacity to benefit from rehabilitation. Development of predictive models to guide selection of most optimal rehabilitation st ....Improved identification of patients 'at risk' of depression, and optimal targeting of rehabilitation post-stroke through novel brain imaging and biomarkers. Use of novel brain imaging and biomarkers for identification of stroke survivors at risk of depression and recurrent stroke will permit early access to preventative and effective treatments for depression and improve capacity to benefit from rehabilitation. Development of predictive models to guide selection of most optimal rehabilitation strategies based on viable brain will maximise the capacity for persons with stroke to reach their full potential for recovery and ensure rehabilitation is more targeted and cost efficient. Improved capacity to benefit from treatment will have ongoing benefits for activity participation and productive living in Australians who experience stroke.Read moreRead less
Understanding progressive vision loss in the eye disease glaucoma. Glaucoma is the second leading cause of irreversible vision loss in elderly Australians, although determining treatment failure is currently very dif?cult. This project will radically improve the measurement of glaucoma progression and treatment failure. We will also address fundamental questions regarding how glaucoma destroys vision.