Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.
Improving the reintroduction success of mammals. Improving the reintroduction success of mammals. This project intends to improve the anti-predator traits of mammals and reduce the population density of introduced predators, using a novel two-pronged approach to combat predation by introduced predators. Predation by cats and foxes is the chief cause of reintroduction failure in Australian mammals. This project will look to improve the reintroduction success of burrowing bettongs outside predator ....Improving the reintroduction success of mammals. Improving the reintroduction success of mammals. This project intends to improve the anti-predator traits of mammals and reduce the population density of introduced predators, using a novel two-pronged approach to combat predation by introduced predators. Predation by cats and foxes is the chief cause of reintroduction failure in Australian mammals. This project will look to improve the reintroduction success of burrowing bettongs outside predator-free sanctuaries by exposing individuals to predators before release and by harnessing the suppressive effects of dingoes on introduced predators. Anticipated outcomes are improved re-introduction protocols for threatened mammals and re-established populations of endangered wildlife outside predator-free-sanctuaries.Read moreRead less
Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantif ....Making Green Guard® greener: enhancing the efficacy of a biopesticide. The project aims to identify naturally occurring micro-organisms to increase the effectiveness of Green Guard ®, which is a biopesticide used against the Australian plague locust. The project will use next-generation sequencing and other molecular techniques to potentially identify candidate microbes or combinations of microbes that can be added to Green Guard to enhance locust susceptibility. The project also aims to quantify the interactive impact of temperature and nutrition on immune function, disease resistance and host-plant quality of plague locusts; and to explore the combined effects of temperature, habitat and Green Guard, in combination with candidate microbes or pathogens, on the behaviour and collective movement of locusts. It is anticipated that this will have implications for management and control strategies.Read moreRead less
Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia ....Modelling and control of mosquito-borne diseases in Darwin using long-term monitoring. Management of mosquito populations is a high public health priority because these insects can spread diseases such as malaria, dengue, Ross River virus, Barmah Forest virus, Murray Valley encephalitis, Japanese encephalitis and Kunjin/West Nile virus. Our research into the effectiveness of mosquito control programs in Darwin is of immediate national relevance and priority given the need to Safeguard Australia from invasive diseases. There is an urgency to undertake our research because global environmental change and increasing movements of people (particularly military personnel) from overseas regions where these diseases are endemic is increasing the vulnerability of northern Australia to the (re)establishment of mosquito borne diseases.Read moreRead less
The effect of aerial spraying of two pesticides on semi-arid grasslands. The project will investigate how two pesticides, fipronil and metarrhizium, used to control locusts, affect semi-arid ecosystems by examining impacts on invertebrates, their predators, lizards and soil processes. The effects will be followed through time in a large scale experiment to determine recovery and compare each pesticide.
Impacts of locust control pesticides on arid-zone fauna. Impacts of locust control pesticides on arid-zone fauna. This project aims to understand how different animals encounter pesticide in the landscape through quantifying residue deposition in arid grasslands and investigating how pesticides used to control locust plagues affect fauna. This project will investigate fenitrothion and fipronil, the main pesticides used in Australia for locust control. It will develop a deposition model for aeria ....Impacts of locust control pesticides on arid-zone fauna. Impacts of locust control pesticides on arid-zone fauna. This project aims to understand how different animals encounter pesticide in the landscape through quantifying residue deposition in arid grasslands and investigating how pesticides used to control locust plagues affect fauna. This project will investigate fenitrothion and fipronil, the main pesticides used in Australia for locust control. It will develop a deposition model for aerial pesticide spraying, determine the short-term effect of sprayed pesticides on the behaviour and condition of free-ranging target fauna that use the environment differently, and quantify the relative importance of dietary and non-dietary exposure routes to gauge the importance of animal behaviour on pesticide exposure. Anticipated outcomes are improved baseline assessments for locusticides.Read moreRead less
Dispersal and gene flow in habitat-forming algae. The temperate coast of Australia has a unique and diverse algal flora. Many of these algae play a central role in subtidal ecology by providing habitat to an astonishing diversity of taxa. Despite this, we have no understanding of levels of gene flow within and among populations of habitat forming algae or how such populations persist in nature. By addressing this lack of knowledge, my research will contribute information that is critical for the ....Dispersal and gene flow in habitat-forming algae. The temperate coast of Australia has a unique and diverse algal flora. Many of these algae play a central role in subtidal ecology by providing habitat to an astonishing diversity of taxa. Despite this, we have no understanding of levels of gene flow within and among populations of habitat forming algae or how such populations persist in nature. By addressing this lack of knowledge, my research will contribute information that is critical for the conservation and management of algal habitats. This is particularly pertinent because anthropogentic stressors are beginning to precipitate significant changes in algal forests along Australia's coastline. Read moreRead less
Building sound ecological restoration strategies for endangered amphibians. This project integrates the principles of ecology and restoration ecology to secure the persistence of a population of an endangered frog in the context of a large urban renewal and ecological rehabilitation precinct at the Sydney Olympic Park. Habitat rehabilitation at the site provides an unrivalled opportunity for ecology to provide robust scientific direction and support for conservation management practices and deve ....Building sound ecological restoration strategies for endangered amphibians. This project integrates the principles of ecology and restoration ecology to secure the persistence of a population of an endangered frog in the context of a large urban renewal and ecological rehabilitation precinct at the Sydney Olympic Park. Habitat rehabilitation at the site provides an unrivalled opportunity for ecology to provide robust scientific direction and support for conservation management practices and develops the site as a model site illustrating adaptive management practices. The project investigates the role of two threatening processes in amphibian decline in a habitat management context and the outcomes have wide implications for the global amphibian decline. Read moreRead less
Development of a vaccine to protect koalas against koala retrovirus (KoRV). This project aims to develop a vaccine against koala retrovirus (KoRV) to arrest the increasing loss of animals due to this infection. Along with Chlamydia, KoRV threatens the long-term survival of the koala. KoRV infects over 95 per cent of Australia’s koalas and has been strongly linked to lymphoma and leukemia. Although quarantine and antiretroviral drug treatment are possible control measures, they are impractical in ....Development of a vaccine to protect koalas against koala retrovirus (KoRV). This project aims to develop a vaccine against koala retrovirus (KoRV) to arrest the increasing loss of animals due to this infection. Along with Chlamydia, KoRV threatens the long-term survival of the koala. KoRV infects over 95 per cent of Australia’s koalas and has been strongly linked to lymphoma and leukemia. Although quarantine and antiretroviral drug treatment are possible control measures, they are impractical in the wild, leaving vaccination as the only realistic option. This is valuable for both wild and captive koalas; zoos report high animal losses due to KoRV-associated lymphoma. The main outcome will be a KoRV vaccine which can be combined with a Chlamydia vaccine which is being developed in parallel.Read moreRead less
From individuals to mass organisation: aggregation, synchronisation and collective movement in locusts. By combining field biology, robotics and mathematics, this project will determine how animals flock or swarm and, in particular, how locust nymphs control their collective movement over their lifetime. The mathematical models derived during the project will be directly applied to controlling outbreaks of locusts in Australia, South and North Africa.