Amelioration Of The Cognitive Deficits In A Model Of Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$542,890.00
Summary
The project investigates a brain molecule called p75, and the part it plays inmemory impairment in Alzheimer's Disease (AD). We predict that p75 is a vital link in the disease processes affecting memory.This research has the potential to lead to an effective treatment for AD, by stimulating work on compounds with the ability to blockthe damaging functions of p75.
How well people perform in everyday situations is often determined by memory function. When required to perform under stress memory performance is often affected. The effect of a psychological stress test on memory function in healthy volunteers and the ability of a dietary supplement, tyrosine, to prevent the effects will be studied. The data may suggest that depletion amino acids is responsible for the decrements in performance that are evident after an acute stressor.
Evaluation Of Rehabilitation Strategies For Prospective Memory In Individuals With Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$213,950.00
Summary
Traumatic brain injury (TBI) resulting from motor vehicle accidents and other mishaps is a leading cause of death and disability in young adults. Memory problems is one of the most common and debilitating symptoms reported by people with TBI. Traditionally, the treatment of memory problems has focussed on retrospective memory or the ability to recall or recognise previously learned information (e.g., remembering the name of a person, recalling the content of yesterday's news stories). Little res ....Traumatic brain injury (TBI) resulting from motor vehicle accidents and other mishaps is a leading cause of death and disability in young adults. Memory problems is one of the most common and debilitating symptoms reported by people with TBI. Traditionally, the treatment of memory problems has focussed on retrospective memory or the ability to recall or recognise previously learned information (e.g., remembering the name of a person, recalling the content of yesterday's news stories). Little research has been conducted on problems with another type of memory called prospective memory or the ability to remember to do something in the future (e.g., remembering to attend an appointment, remembering to pay a bill before its due date). The treatment of prospective memory problems in people with TBI is, however, very important for assisting them to return to work and successful integration into the community. This is because the ability to remember to do things at the right time is essential for work and for independent living. In addition, failure to treat this type of problems can be risky or even life threatening (e.g., forgetting to take medication, forgetting to turn off an electrical appliance). This project aims to evaluate the independent and combined effectiveness of two rehabilitation strategies, namely, promoting awareness of memory problems and adopting compensatory strategies. In addition, this project aims to gauge whether a better management of prospective memory problem will lead to better functioning in the community.Read moreRead less
The Extinction Of Conditioned Fear And Its Implications For Cue Exposure Therapy
Funder
National Health and Medical Research Council
Funding Amount
$322,430.00
Summary
This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavl ....This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavlovian conditioning, subjects (typically rats) are exposed to a signaling relation between an initially neutral stimulus (e.g., a noise) and a feared outcome (e.g., foot shock). When later repeatedly exposed to the initially neutral but now feared stimulus (the noise) in the absence of the feared outcome, the fear reactions it acquired progressively decline until eventually it fails to elicit any such reactions. The fear reactions are said to have been extinguished. There has been significant progress in understanding the psychological processes and neural mechanisms underlying the acquisition of fear reactions, but much less is known about the processes and mechanisms underlying the extinction of these reactions. The project has two general objectives. The first is to determine the conditions of extinction training that promote long-term loss of fear reactions. The second objective is to determine how the brain controls this extinction of learned fear. Achieving these aims will be significant for two reasons. First, it will contribute to understanding the mechanisms by which animals (including people) learn to adjust their behaviour to bring it into line with the current relations that exist between events in the world. Second, it will provide important information about how such adjustment is facilitated or impaired across extinction training and, thereby, contribute towards understanding both the successes and failures of cue exposure therapy for fear-related disorders.Read moreRead less