Novel dopamine pathways underlying motivated behaviours. Rewards such as food, sex and social media are seeked on daily basis. Neurological and psychological basis of learning and memory of reward processing behaviour. This project maps real time neural activity during reward processing in two novel brain regions. It has the potential to revolutionize the understanding of the brain mechanisms in reward processing. The biological data obtained can be directly integrated into computational modelli ....Novel dopamine pathways underlying motivated behaviours. Rewards such as food, sex and social media are seeked on daily basis. Neurological and psychological basis of learning and memory of reward processing behaviour. This project maps real time neural activity during reward processing in two novel brain regions. It has the potential to revolutionize the understanding of the brain mechanisms in reward processing. The biological data obtained can be directly integrated into computational modelling approaches to benefit reward processing algorithms for learning behaviours in humans or artificial intelligence. This project will fuel the understanding of algorithms driving social media platforms and consumer consumption, hence driving economic and technological progress in Australia.Read moreRead less
Investigating the role of Zona Incerta RXFP3+ cells in learning and memory. Learning and memory are fundamental to human and animal behaviour. We identified a specific population of cells in the zona incerta of the brain, where activation inhibits expression of memory, and facilitates the acquisition of new learning. Aside from our observations, nothing is currently known about the anatomy and function of these cells. This project aims to map how they connect to the rest of the brain, to observe ....Investigating the role of Zona Incerta RXFP3+ cells in learning and memory. Learning and memory are fundamental to human and animal behaviour. We identified a specific population of cells in the zona incerta of the brain, where activation inhibits expression of memory, and facilitates the acquisition of new learning. Aside from our observations, nothing is currently known about the anatomy and function of these cells. This project aims to map how they connect to the rest of the brain, to observe how these connections are recruited during learning and memory, and then to test their function experimentally. The outcomes will extend the known neural circuitry that controls learning by defining how and where these unexplored pathways fit within it; thus advancing knowledge regarding neural regulation of behaviour.
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Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as pred ....Hunger flexibly modifies hypothalamic neural circuits responding to threat. Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as predator cues, enhance avoidance behaviour. This project will uncover the neural circuitry and endocrine mechanisms through which hunger influences hypothalamic threat-detecting circuits that suppress food intake. These studies provide a new hypothalamic model to understand risk/reward decision in the brain.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101097
Funder
Australian Research Council
Funding Amount
$395,127.00
Summary
Treatment-induced compulsive behaviours: Ethical and policy implications. Compulsive behaviours represent one of the largest preventable burdens in society. Some medications, such as those used to treat Parkinson's disease, can produce severe compulsions in certain individuals, which are akin to addiction. This project will explore: neurocognitive changes caused by these medications; the impact that drug-induced compulsive behaviours have on affected individuals, their sense of agency, identity ....Treatment-induced compulsive behaviours: Ethical and policy implications. Compulsive behaviours represent one of the largest preventable burdens in society. Some medications, such as those used to treat Parkinson's disease, can produce severe compulsions in certain individuals, which are akin to addiction. This project will explore: neurocognitive changes caused by these medications; the impact that drug-induced compulsive behaviours have on affected individuals, their sense of agency, identity and moral responsibility; and the ethical, legal and policy consequences of drug-induced behaviour. This project will help us to understand the neuropsychology of compulsive behaviour and reduce its occurrence. It will also enable society to meet the ethical and policy challenges raised by neuroscience research on compulsive behaviour.Read moreRead less
The neuronal bases of consciousness and attention. Why and how do some electrical activities in the brain make us see, hear and feel pain? Why other neural activities remain non-conscious? This project will utilise visual illusions combined with a range of state-of-the-art neuroimaging techniques to understand what kind of neuronal mechanisms underlie attention and consciousness.
Humans as animals and objects: the psychology of dehumanisation. This project will clarify how some individuals and groups as perceived as less than human. It will examine how some groups are subtly seen as animal-like and how some media images objectify individuals. It will yield a deeper understanding of how people may be degraded, dismissed, vilified and dehumanised.
A social psychology of affective disturbance. We are in the midst of a depression and anxiety epidemic that cannot be explained by focusing on individual experiences alone. We desperately need to understand the cultural contributors to depression and anxiety, thereby providing insight into the epidemiology of these conditions. Drawing on experimental studies, longitudinal sampling of daily emotional experiences, and multi-national data, the research will show how cultural contexts may exacerbate ....A social psychology of affective disturbance. We are in the midst of a depression and anxiety epidemic that cannot be explained by focusing on individual experiences alone. We desperately need to understand the cultural contributors to depression and anxiety, thereby providing insight into the epidemiology of these conditions. Drawing on experimental studies, longitudinal sampling of daily emotional experiences, and multi-national data, the research will show how cultural contexts may exacerbate individual-level affective disturbance and demonstrate the processes through which occurs. The findings will make a timely and much needed contribution to public policy decisions and preventive health care.Read moreRead less
The impact of motherhood on fear extinction in rats. This project aims to identify how motherhood, a time of significant hormonal flux, alters the mechanisms underlying fear regulation in female rats. Current theories of fear regulation are limited because they have been derived from studies that have focused on males but recent work suggests that sex hormones influence fear regulation. The expected outcomes of this project will help to develop a more ecologically valid model of fear regulation ....The impact of motherhood on fear extinction in rats. This project aims to identify how motherhood, a time of significant hormonal flux, alters the mechanisms underlying fear regulation in female rats. Current theories of fear regulation are limited because they have been derived from studies that have focused on males but recent work suggests that sex hormones influence fear regulation. The expected outcomes of this project will help to develop a more ecologically valid model of fear regulation that accounts for fluctuations in female sex hormones and reproductive experience. This should provide unique insights into fear reduction and protection against anxiety.Read moreRead less
Understanding the emotional brain in risk for depression. The burden of illness due to depression is enormous; family disruption, lost productivity and a high healthcare spend. There are no objective ways to target who will benefit most from preventative programs. This study will detail for the first time how genetic risk may develop into overt depression due to effects on emotional brain systems.
Investigating anticipatory traumatic threat in refugees and asylum seekers. This project seeks to establish how traumatic threat differs from post-traumatic stress and generalised worry. Research into traumatic stress has focused on the pathogenic role of past trauma. There has been little research among populations facing ongoing traumatic threat. A cluster of future-oriented threat-related intrusive symptoms has been identified among refugees with insecure residency that is distinct from post- ....Investigating anticipatory traumatic threat in refugees and asylum seekers. This project seeks to establish how traumatic threat differs from post-traumatic stress and generalised worry. Research into traumatic stress has focused on the pathogenic role of past trauma. There has been little research among populations facing ongoing traumatic threat. A cluster of future-oriented threat-related intrusive symptoms has been identified among refugees with insecure residency that is distinct from post-traumatic stress and worry. The project aims to investigate this traumatic threat response using descriptive and experimental approaches. The findings from this study may lay the foundation of a revised understanding of the human response to traumatic threat.Read moreRead less