Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions. Nanomaterials exposed to biological environments such as blood or lymph fluids rapidly adsorb a layer of biomolecules on their surface, forming a biomolecular corona, and profoundly altering their properties. This project aims to resolve the influence of biomolecular coronas on nanoparticle–immune cell interactions by combining particle engineering, immunology, proteomics and bioinformatic analysis. The project expected outc ....Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions. Nanomaterials exposed to biological environments such as blood or lymph fluids rapidly adsorb a layer of biomolecules on their surface, forming a biomolecular corona, and profoundly altering their properties. This project aims to resolve the influence of biomolecular coronas on nanoparticle–immune cell interactions by combining particle engineering, immunology, proteomics and bioinformatic analysis. The project expected outcomes are to generate new knowledge in nanomaterial–immune cell behaviour and design principles for nanoparticles with prospective applications in the agricultural, veterinary and biomedical sectors.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100017
Funder
Australian Research Council
Funding Amount
$3,115,000.00
Summary
Nanoscale-interactions making future functional materials more powerful . Traditional crystal chemistry can no longer meet the demands for development of new functional materials - the foundation of modern industry. The program aims to overcome this challenge by introducing a new strategy into experimental and theoretical research to transform our understanding and application of nanoscale structural and chemical features in materials. The program expects to build new crystal chemistry that incl ....Nanoscale-interactions making future functional materials more powerful . Traditional crystal chemistry can no longer meet the demands for development of new functional materials - the foundation of modern industry. The program aims to overcome this challenge by introducing a new strategy into experimental and theoretical research to transform our understanding and application of nanoscale structural and chemical features in materials. The program expects to build new crystal chemistry that includes nanoscale-interaction information and deep machine-learning to improve the predictability of material properties. Potential outcomes of the program include enhanced capacity for revolutionary materials development thus keeping Australia's leading position in innovative technology, benefiting academia and industry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101156
Funder
Australian Research Council
Funding Amount
$426,476.00
Summary
Preconcentrators for vapour detection of explosive material. This Project’s aim is to develop a preconcentrator technology for the in-field detection of explosive vapours that have low concentrations in air. Low explosive vapour concentration limits the efficacy of portable detectors. Current preconcentrator technologies sorb vapours but require heat to release the concentrated material limiting their use to non-portable detectors. This project is expected to deliver materials and a device modul ....Preconcentrators for vapour detection of explosive material. This Project’s aim is to develop a preconcentrator technology for the in-field detection of explosive vapours that have low concentrations in air. Low explosive vapour concentration limits the efficacy of portable detectors. Current preconcentrator technologies sorb vapours but require heat to release the concentrated material limiting their use to non-portable detectors. This project is expected to deliver materials and a device module for a preconcentrator technology that will sorb explosive analytes, have low power requirements and be compatible with hand held explosives detectors. Security and law enforcement agencies should directly benefit from these findings, which would advance their safety and that of the community as a whole.Read moreRead less
Nanoengineering of Biomaterial Surfaces to Tailor Innate Immune Responses. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Recently, we showed that surface nanotopography induced conformational changes in adsorbed proteins can activate or deactivate immune cells. These exciting findings are important because they show that it may be possible to engineer the nanotopography of a biomedical device surface in ....Nanoengineering of Biomaterial Surfaces to Tailor Innate Immune Responses. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Recently, we showed that surface nanotopography induced conformational changes in adsorbed proteins can activate or deactivate immune cells. These exciting findings are important because they show that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation. The outcomes of the project will create new fundamental knowledge that in the future can instruct the development of the next generation of biomaterials capable of controlling and directing the body’s inflammatory responses.Read moreRead less
Combating Antimicrobial Resistance with Bismuth, Gallium and Indium. This research project focuses on the design, development, and application of new bismuth, gallium and indium compounds as antimicrobial agents. These metals act as iron mimics in vivo and can exert antimicrobial activity while displaying low systemic toxicity in humans. The project aims to exploit this, and the inability of microbes to easily develop resistance towards metals, to combat bacteria for which modern drugs are rapid ....Combating Antimicrobial Resistance with Bismuth, Gallium and Indium. This research project focuses on the design, development, and application of new bismuth, gallium and indium compounds as antimicrobial agents. These metals act as iron mimics in vivo and can exert antimicrobial activity while displaying low systemic toxicity in humans. The project aims to exploit this, and the inability of microbes to easily develop resistance towards metals, to combat bacteria for which modern drugs are rapidly becoming ineffective, as highlighted in the WHO and US Centre for Disease Control list of critical and priority pathogens. The intended outcome is that efficacy will be driven through advances in synthetic and structural chemistry, discovering the mode of action, and creating anti-infective coatings and hydrogels.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL180100029
Funder
Australian Research Council
Funding Amount
$2,545,000.00
Summary
Nanoionics: Engineering ion transport with two-dimensional materials. This project aims to use graphene and other emerging two-dimensional materials to investigate and manipulate ion transport in nanoscale channels. Nanoionics focuses on understanding ions for transport and storage in nanoscale systems, central to numerous technologies related to water, energy and biomedicine. The project will provide sophisticated methods for revolutionary technological innovations to solve problems in several ....Nanoionics: Engineering ion transport with two-dimensional materials. This project aims to use graphene and other emerging two-dimensional materials to investigate and manipulate ion transport in nanoscale channels. Nanoionics focuses on understanding ions for transport and storage in nanoscale systems, central to numerous technologies related to water, energy and biomedicine. The project will provide sophisticated methods for revolutionary technological innovations to solve problems in several industries including manufacturing, mining, water management and bioengineering. Providing access to previously unavailable structures and materials, the project will support Australia’s manufacturing sector by transforming established industries with next generation technologies. The project will also build capacity of nanoionics engineers and provide intellectual property for commercialised products.Read moreRead less
Macromolecular Engineering of Functional Metal–Ligand Materials. Materials self-assembled from metal ions and ligands have a range of important applications, including as advanced coatings, adhesives and catalysts. However, these materials have been largely limited to those assembled from naturally occurring ligands such as phenolics, restricting their properties and function. This project aims to greatly expand the range of accessible properties of metal–phenolic materials by combining self-ass ....Macromolecular Engineering of Functional Metal–Ligand Materials. Materials self-assembled from metal ions and ligands have a range of important applications, including as advanced coatings, adhesives and catalysts. However, these materials have been largely limited to those assembled from naturally occurring ligands such as phenolics, restricting their properties and function. This project aims to greatly expand the range of accessible properties of metal–phenolic materials by combining self-assembly with advanced polymer synthesis techniques. The expected outcome of the project is a new class of functional materials applicable as self-healing coatings, nanoadhesives and antimicrobial surfaces, thus underpinning next-generation technologies in materials science and nanotechnology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100435
Funder
Australian Research Council
Funding Amount
$383,982.00
Summary
Photonic Crystal Sensors for Intelligent Packaging. This project aims to synthesize and investigate the properties of optical sensors composed of oriented assembled, high-flexible metal-organic-framework-based photonic crystals. This project is expected to generate new knowledge in the area of oriented self-assembly and elucidate the relationship between the optical properties of photonic crystal optical sensors and the orientation, flexibility and functionalisation of metal-organic frameworks. ....Photonic Crystal Sensors for Intelligent Packaging. This project aims to synthesize and investigate the properties of optical sensors composed of oriented assembled, high-flexible metal-organic-framework-based photonic crystals. This project is expected to generate new knowledge in the area of oriented self-assembly and elucidate the relationship between the optical properties of photonic crystal optical sensors and the orientation, flexibility and functionalisation of metal-organic frameworks. Expected outcomes of this project include novel oriented assembly methods and a series of optical sensing devices for various detection scenarios. This research will provide significant benefits on environmental protection, sustainable development, food safety and human health.Read moreRead less
Synthetic leukocytes: bio-inspired DNA nanorobots powered by flow. Inspired by the way white blood cells roll along blood vessel walls, our goal is to build DNA nanorobots that roll along surfaces in flow. We take a synthetic biology approach to using biomolecules, such as DNA and proteins, to build functional particles and surfaces. To achieve this, we will combine our teams’ technological advances in DNA nanotechnology, plasma-activation for biomolecule immobilisation, and microfluidic devices ....Synthetic leukocytes: bio-inspired DNA nanorobots powered by flow. Inspired by the way white blood cells roll along blood vessel walls, our goal is to build DNA nanorobots that roll along surfaces in flow. We take a synthetic biology approach to using biomolecules, such as DNA and proteins, to build functional particles and surfaces. To achieve this, we will combine our teams’ technological advances in DNA nanotechnology, plasma-activation for biomolecule immobilisation, and microfluidic devices. This project will contribute new methods for synthetic particle motion in flow and provide new insights into biomolecule interactions and motion. Ultimately, this will allow us to harness rolling for the delivery of synthetic nanorobots for detection and remediation in flow systems, such as the body.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101120
Funder
Australian Research Council
Funding Amount
$419,904.00
Summary
2D Janus Nanoparticle Superlattice Sheets. The project aims to fabricate novel 2D free-standing Janus superlattices by developing a new ligand-symmetry breaking strategy. The proposed approach expects to generate new knowledge in the area of self-assembly and the new class of 2D plasmonic nanomaterials. Expected outcomes of this project include the fabrication of a series of 2D Janus superlattices that are difficult or impossible to achieve in traditional methods, investigate their functional-pr ....2D Janus Nanoparticle Superlattice Sheets. The project aims to fabricate novel 2D free-standing Janus superlattices by developing a new ligand-symmetry breaking strategy. The proposed approach expects to generate new knowledge in the area of self-assembly and the new class of 2D plasmonic nanomaterials. Expected outcomes of this project include the fabrication of a series of 2D Janus superlattices that are difficult or impossible to achieve in traditional methods, investigate their functional-properties relationship and further apply them into dual-functional plasmonic-catalyst/sensor/filtration applications. This should provide significant benefits, such as developing new design principles for self-assembly and advance Australian expertise in the field of functional nanomaterials.Read moreRead less