Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestio ....Designer Nanoparticles Enable mRNA Protein Factories. Intracellular delivery of mRNA facilitates target protein production, which could build protein factories that are essential in biomanufacturing industries. However, the instability of mRNA greatly lowers the protein production performance, limiting the commercial translation potential. This project aims to develop a new generation of nanoparticle delivery system to enhance mRNA stability against intracellular unstable cue, enzymatic digestion and thermal stress. This will be achieved by tailoring the nanochemistry at multi-scales. Expected outcomes include new knowledge in custom-design of functional nanomaterials for mRNA delivery, and new technology that will bring commercial benefits to the partner organisation and the biopharma sector.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100086
Funder
Australian Research Council
Funding Amount
$510,000.00
Summary
Integrated multimodal microscopy facility for single molecule analysis. This project aims to establish an integrated multimodal microscopy facility in Australia for extensive structural characterization of functional and biological materials at the nanoscale and single molecule level. Discoveries using the facility will provide new insights into the relationship between molecules, materials, and their functions. The key outcomes and benefits of this facility are to i) strengthen the research eff ....Integrated multimodal microscopy facility for single molecule analysis. This project aims to establish an integrated multimodal microscopy facility in Australia for extensive structural characterization of functional and biological materials at the nanoscale and single molecule level. Discoveries using the facility will provide new insights into the relationship between molecules, materials, and their functions. The key outcomes and benefits of this facility are to i) strengthen the research effort in materials science and biotechnology, ii) advance the development of functional materials for biosensing and energy storage, and iii) create new catalysts for green energy conversion. The funding will ensure researchers have access to the latest technology critical to maintaining world-class research.Read moreRead less
Engineering Functional Antimicrobial Polypeptide Surfaces. Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims ....Engineering Functional Antimicrobial Polypeptide Surfaces. Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims to exploit the adhesive nature of metal–phenolic materials to rapidly coat diverse surfaces, including stainless steel and textiles. The expected outcome is the generation of antimicrobial polypeptide surfaces, which will have benefits in food safety, medical implant technology and advanced textiles.Read moreRead less
Innovative Stable Free Radical-Substituted Conjugated Electronic Polymers. The project aims to develop an innovative class of stable free radicals side-chain substituted conjugated donor-acceptor electronic polymers with unique polaronic and radical charge transport capabilities. The targeted optoelectronic material class is unique and has not been explored in depth before. The combination of unpaired electrons and delocalized backbone -electrons delivers exciting modes of charge transfer that ....Innovative Stable Free Radical-Substituted Conjugated Electronic Polymers. The project aims to develop an innovative class of stable free radicals side-chain substituted conjugated donor-acceptor electronic polymers with unique polaronic and radical charge transport capabilities. The targeted optoelectronic material class is unique and has not been explored in depth before. The combination of unpaired electrons and delocalized backbone -electrons delivers exciting modes of charge transfer that provide these novel materials with clear potential as electroactive materials with applications in various nanoelectronics devices. Developing a fundamental understanding of charge transport properties and potential device applications will open up a new field of research in advanced optoelectronic technology. Read moreRead less
Nanobionic sensors for Real-Time Plant Health Monitoring. This project aims to develop nanosensors to detect and monitor plant health in real-time by measuring stress molecules. The project will create new knowledge on functional materials with unique optical, electronic and thermal properties as well as their bio-nano interactions with plants. The expected outcomes of the project will provide insight into 1) how localised nanosensors target organelles in living plants to 2) generate signals tha ....Nanobionic sensors for Real-Time Plant Health Monitoring. This project aims to develop nanosensors to detect and monitor plant health in real-time by measuring stress molecules. The project will create new knowledge on functional materials with unique optical, electronic and thermal properties as well as their bio-nano interactions with plants. The expected outcomes of the project will provide insight into 1) how localised nanosensors target organelles in living plants to 2) generate signals that can be picked up by portable devices to 3) report on plant health. Functional nanosensors will enable smart farming, precision agriculture and contribute to future agronomic research, further strengthening Australia’s position as an international leader in nanobiotechnology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100032
Funder
Australian Research Council
Funding Amount
$456,547.00
Summary
Chemical and structural design for high power energy storage materials. This project aims to develop new materials with both high power and high energy storage capabilities by exploring emerging relaxor antiferroelectric (RAFE) materials. Through investigating the internal chemical and structural factors, and their interactions at different length scales, this project will first solve the current ambiguities in RAFEs and then identify critical factors for properties to better design and develop ....Chemical and structural design for high power energy storage materials. This project aims to develop new materials with both high power and high energy storage capabilities by exploring emerging relaxor antiferroelectric (RAFE) materials. Through investigating the internal chemical and structural factors, and their interactions at different length scales, this project will first solve the current ambiguities in RAFEs and then identify critical factors for properties to better design and develop new high-performance energy storage materials. The outcomes of this project will advance the knowledge of ferroic materials, provide new candidates for advanced electrical systems such as renewable energy, electric vehicles and pulsed power devices, and potentially revolutionise high power energy storage technologies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100480
Funder
Australian Research Council
Funding Amount
$445,237.00
Summary
Electrolyte design for high-performance, sustainable sodium batteries. This project aims to develop sustainable high-performance sodium batteries by investigating new non-flammable and safe electrolyte chemistries. The project will generate knowledge in materials chemistry for battery electrolytes that will underpin improvements in battery technology and help to move society towards a zero-carbon economy. The outcomes will provide materials suitable for prototyping reliable, safe and sustainable ....Electrolyte design for high-performance, sustainable sodium batteries. This project aims to develop sustainable high-performance sodium batteries by investigating new non-flammable and safe electrolyte chemistries. The project will generate knowledge in materials chemistry for battery electrolytes that will underpin improvements in battery technology and help to move society towards a zero-carbon economy. The outcomes will provide materials suitable for prototyping reliable, safe and sustainable batteries in Australia and enhance research collaborations with local and international industry partners. These advances will contribute to reliable, affordable, and sustainable energy storage systems, positioning Australia at the forefront of advanced battery research.Read moreRead less
Zwitterion-based electrolytes for advanced energy technologies. This research aims to develop a new class of electrolyte that is safer, non-flammable and designed to enable excellent performance of high energy batteries made with either sodium or lithium. Through the synthesis of new electrolyte structures that are designed to improve stability and electrochemical properties, and using a range of analysis techniques to understand the material properties, the project aims to solve some of the saf ....Zwitterion-based electrolytes for advanced energy technologies. This research aims to develop a new class of electrolyte that is safer, non-flammable and designed to enable excellent performance of high energy batteries made with either sodium or lithium. Through the synthesis of new electrolyte structures that are designed to improve stability and electrochemical properties, and using a range of analysis techniques to understand the material properties, the project aims to solve some of the safety and performance problems that plague existing electrolytes. Expected benefits include new functional energy materials for safer, more reliable energy storage technologies, plus research training, collaborations and materials development capabilities to help position Australia as a global leader in this field.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240101231
Funder
Australian Research Council
Funding Amount
$411,837.00
Summary
Quinoid Polymers for Organic Electrochemical Transistors and Bioelectronics. This project aims to develop organic semiconductors (OSCs) with excellent mechanical flexibility and biocompatibility to exploit their potentials in bioelectronics. It connects the electronic world with ionic world of biology to push the biomedical application of OSCs a big step forward. Interdisciplinary knowledge, intellectual properties (IPs), top-notch publications, invited talks, and international collaborations ar ....Quinoid Polymers for Organic Electrochemical Transistors and Bioelectronics. This project aims to develop organic semiconductors (OSCs) with excellent mechanical flexibility and biocompatibility to exploit their potentials in bioelectronics. It connects the electronic world with ionic world of biology to push the biomedical application of OSCs a big step forward. Interdisciplinary knowledge, intellectual properties (IPs), top-notch publications, invited talks, and international collaborations are expected. Additionally, it will earn Australia a commercial lead in the biomedical sector to attract more talents to serve Australia. This project also matches well with several government’s strategic research priorities, attracting industries to realise IPs transfer to bring “great value for money” to feed back Australia.Read moreRead less
Mixed-Dimensional 2D/0D Heterostructures for Infrared Detection. The aim of this proposal is to develop novel mixed-dimensional 2D/0D heterostructures based on halide and chalcogenide nanomaterials to construct a highly efficient solution-processing platform for short wave infrared detection. Moreover, innovative low-dose transmission electron microscopy and spectroscopy will be applied to unveil the fundamental structure-property relationship and fill the gap of knowledge for these materials. S ....Mixed-Dimensional 2D/0D Heterostructures for Infrared Detection. The aim of this proposal is to develop novel mixed-dimensional 2D/0D heterostructures based on halide and chalcogenide nanomaterials to construct a highly efficient solution-processing platform for short wave infrared detection. Moreover, innovative low-dose transmission electron microscopy and spectroscopy will be applied to unveil the fundamental structure-property relationship and fill the gap of knowledge for these materials. Such mixed-dimensional nano-heterostructures combining 2D halide perovskites with 0D quantum dots with complementary physical properties and atomically resolved interfaces will significantly enhance the performance, thereby enabling breakthroughs in a broad range of disruptive optoelectronic technologies. Read moreRead less