Mapping the dark matter with early type galaxies. Unidentified dark matter outweighs luminous matter (stars, gas, and galaxies) by several times and is detected by its gravitational effects in the Universe. The Six Degree Field Galaxy Survey is now complete and this project will prepare a larger survey, which will put the team clearly in the lead in understanding the distribution of dark matter.
Electron Transpiration Cooling of Hypersonic Vehicles. Future aircraft for flight at hypersonic speeds require sharp leading edges for the best aerodynamic performance. Sharp leading edges incur high heat loads and cannot be adequately cooled with current technologies. The project aim is to investigate novel surface materials that emit electrons when heated. This emission of electrons from the surface can significantly contribute to the cooling of the sharp leading edges. This project is expecte ....Electron Transpiration Cooling of Hypersonic Vehicles. Future aircraft for flight at hypersonic speeds require sharp leading edges for the best aerodynamic performance. Sharp leading edges incur high heat loads and cannot be adequately cooled with current technologies. The project aim is to investigate novel surface materials that emit electrons when heated. This emission of electrons from the surface can significantly contribute to the cooling of the sharp leading edges. This project is expected to deliver new experimental data on novel surface materials exposed to a hypersonic flow environment and computer models that can simulate their cooling effect. This investigation will contribute towards enabling technologies for sustained hypersonic flight by overcoming critical head load limitations.Read moreRead less
Wind Tunnel Testing of a Hypersonic Plasma Engine. This project intends to evaluate an electric engine that is capable of speeds in excess of 10000 km/hr, for access to space and responsive surveillance in our region. The expertise of Lockheed Martin, Lockheed Martin Australia, the University of Qld and DST Group are to be combined to complete experimental and theoretical evaluations of an air-breathing plasma engine that is capable of out-performing rockets and scramjets. US Air Force Research ....Wind Tunnel Testing of a Hypersonic Plasma Engine. This project intends to evaluate an electric engine that is capable of speeds in excess of 10000 km/hr, for access to space and responsive surveillance in our region. The expertise of Lockheed Martin, Lockheed Martin Australia, the University of Qld and DST Group are to be combined to complete experimental and theoretical evaluations of an air-breathing plasma engine that is capable of out-performing rockets and scramjets. US Air Force Research Laboratory results will also be compared and shared. This project provides opportunities for young Australian researchers to be participate and lead an exciting new field of propulsion. It is anticipated that the program will be the foundations to future flight demonstrations from Woomera, Australia.Read moreRead less
Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links betwee ....Elucidating structure and function of activation-associated secreted proteins (ASPs) in blood-feeding hookworms – toward new methods of control. The national/community benefits are: (1) to develop a long-term, high quality scientific and technological program contributing to national objectives, including the maintenance of a strong capability in basic research, the development of new scientific concepts and the enhancement of international collaborative links; (2) to strengthen the links between basic and applied research; (3) to develop excellence in research by promoting collaborative research, resulting in a more efficient use of resources in a national and international context; (4) to enhance the skills-base in biology and biotechnology; (5) to substantially increase global visibility through quality research, leading to an increased investment in Australian science.Read moreRead less
QUANTIFICATION OF INTERACTIONS DURING THE DISPERSION OF CORONA IONS AND AIRBORNE PARTICLES NEAR POWER LINES. Currently there is no method for quantification of concentration and dispersion of charged aerosols near high voltage power lines (HVPLs). However, hypothesis have been presented, but not yet proven scientifically, that residents of houses close to combustion sources such as highways or industrial plants and HVPLs may be subjected to health risk due to inhalation of charged aerosols. The ....QUANTIFICATION OF INTERACTIONS DURING THE DISPERSION OF CORONA IONS AND AIRBORNE PARTICLES NEAR POWER LINES. Currently there is no method for quantification of concentration and dispersion of charged aerosols near high voltage power lines (HVPLs). However, hypothesis have been presented, but not yet proven scientifically, that residents of houses close to combustion sources such as highways or industrial plants and HVPLs may be subjected to health risk due to inhalation of charged aerosols. The outcome of this project will be a model for quantitative assessment of the processes occurring during the transport and dispersion of corona ions and combustion aerosol, which will be a tool for predictive risk assessment and informed management of public resources in relation to power line design and maintenance.Read moreRead less
Translating pharmacokinetic and pharmacodynamic data to better design new drugs for the treatment of Trypanosoma cruzi infection. New drugs to treat T. cruzi infection are urgently needed, however their design has been hampered by an incomplete understanding of complex host-parasite interactions, inadequate in vitro and in vivo tools to rigorously define activity during drug discovery, and a poor appreciation of concentration/effect relationships. This project aims to develop new and much needed ....Translating pharmacokinetic and pharmacodynamic data to better design new drugs for the treatment of Trypanosoma cruzi infection. New drugs to treat T. cruzi infection are urgently needed, however their design has been hampered by an incomplete understanding of complex host-parasite interactions, inadequate in vitro and in vivo tools to rigorously define activity during drug discovery, and a poor appreciation of concentration/effect relationships. This project aims to develop new and much needed in vitro methods to better define the kinetic and dynamic activity of new drug candidates, and will provide a rational basis for translating this information into lengthy animal models of T. cruzi infection. The outcome aims to be rationally designed drug candidates that are available in a shorter period of time and are suitable for further development.Read moreRead less
The early communicative environment prior to and following cochlear implants: impact on children's early communicative and cognitive development. This research with children with cochlear implants will examine the effect on language development of being in an oral environment or one that also includes sign language. The outcomes will provide information for parents and professionals enabling informed decision about the management of the children to promote the best possible outcomes.
Oxytocin receptor PET ligands: imaging the love receptor’s engagement. This project aims to develop a positron emission tomography (PET) ligand for the oxytocin receptor. This novel platform is significant as it will allow the scientific community to answer questions about the role of the oxytocin receptor in the important process of social behaviour which underlies quality of life. This knowledge gap has remained unanswered for decades due to the lack of specific techniques to measure oxytocin ....Oxytocin receptor PET ligands: imaging the love receptor’s engagement. This project aims to develop a positron emission tomography (PET) ligand for the oxytocin receptor. This novel platform is significant as it will allow the scientific community to answer questions about the role of the oxytocin receptor in the important process of social behaviour which underlies quality of life. This knowledge gap has remained unanswered for decades due to the lack of specific techniques to measure oxytocin receptor engagement. It is also significant as it will equip Australian startup Kinoxis Therapeutics to progress their molecules to market, a process enabled by measuring oxytocin receptor engagement. Our dual expertise on the oxytocin receptor and PET ligand development uniquely situate us to generate this technology.Read moreRead less
Targeting virulence of Pseudomonas aeruginosa by inhibiting oxidative protein folding. Our research will lead to the development of compounds with a novel anti-virulence/antibacterial mode of action for further drug development.
The flotation of oxide minerals using hydroxamate collectors. Australian and world mineral resources are declining in quality as we exploit the richest sulfidic ore deposits. This is increasing our reliance on concentration and beneficiation processes to improve the economics of the selective recovery of minerals from lower grade and, increasingly, oxide or lateritic ore bodies. In addition, greater emphasis is being placed on our environmental stewardship and the need to remove hazardous mater ....The flotation of oxide minerals using hydroxamate collectors. Australian and world mineral resources are declining in quality as we exploit the richest sulfidic ore deposits. This is increasing our reliance on concentration and beneficiation processes to improve the economics of the selective recovery of minerals from lower grade and, increasingly, oxide or lateritic ore bodies. In addition, greater emphasis is being placed on our environmental stewardship and the need to remove hazardous material from the concentrate streams. This proposal will develop improved methods and techniques that will facilitate better, cleaner separations and recovery of the valuable oxide mineral components using Australian-developed flotation reagents.Read moreRead less