The Dawn of Extreme Gamma Ray Astronomy. This project aims to reveal the highest energy cosmic-ray particles in our galaxy, produced in extreme and still unknown astrophysical processes. Their interaction with nuclei in space produces the highest energy gamma ray light. Our project will make use of this extreme gamma ray light with upgraded and next-generation gamma-ray telescope arrays. With accompanying data from Australian radio telescopes, and computer models of the cosmic ray interactions, ....The Dawn of Extreme Gamma Ray Astronomy. This project aims to reveal the highest energy cosmic-ray particles in our galaxy, produced in extreme and still unknown astrophysical processes. Their interaction with nuclei in space produces the highest energy gamma ray light. Our project will make use of this extreme gamma ray light with upgraded and next-generation gamma-ray telescope arrays. With accompanying data from Australian radio telescopes, and computer models of the cosmic ray interactions, our project can finally determine from where these cosmic rays originate, yielding insight into our galaxy's evolution. Complex machine learning methods will be needed in a project that provides a world-leading student training ground, motivated by a century old mystery in astronomy.Read moreRead less
Exploring the High Energy Universe with Neutrinos detected in IceCube. The project aims to use the high energy neutrinos observed by the IceCube detector at the South Pole to uncover
the nature of the most energetic objects in the Universe. This project expects to find out what distant objects made
the neutrinos, understand their distribution through the Universe, and see if they are also cosmic and gamma ray
acceleration and production sites. Expected outcomes of this project include solving th ....Exploring the High Energy Universe with Neutrinos detected in IceCube. The project aims to use the high energy neutrinos observed by the IceCube detector at the South Pole to uncover
the nature of the most energetic objects in the Universe. This project expects to find out what distant objects made
the neutrinos, understand their distribution through the Universe, and see if they are also cosmic and gamma ray
acceleration and production sites. Expected outcomes of this project include solving this long-standing mystery in
high-energy astrophysics, development of new data analysis techniques, training new scientists, and educating
the public. These should provide significant benefits to science and society, through a better educated and critical
thinking workforce and public, ready to face future challenges.Read moreRead less
Understanding the nature and origin of the highest energy cosmic rays. This project aims to harness the capabilities of the upgraded Pierre Auger Observatory to identify sources of the highest energy cosmic rays, the most energetic particles known in the Universe. Their origin is one of the longest standing mysteries in astrophysics, but answers are now within reach. Expected outcomes of the project include mass estimates for every measured cosmic ray, and sky maps of cosmic ray arrival direct ....Understanding the nature and origin of the highest energy cosmic rays. This project aims to harness the capabilities of the upgraded Pierre Auger Observatory to identify sources of the highest energy cosmic rays, the most energetic particles known in the Universe. Their origin is one of the longest standing mysteries in astrophysics, but answers are now within reach. Expected outcomes of the project include mass estimates for every measured cosmic ray, and sky maps of cosmic ray arrival directions that take into account the cosmic ray charge, minimising the effects of path deflections by cosmic magnetic fields. These maps will reveal new information on the types of astrophysical objects capable of accelerating particles to extreme energies, a major step towards solving this difficult problem.Read moreRead less
How archaeology can transform living in space. This project aims to investigate human engagement with material culture in the extreme environment of space by applying archaeological methods to the habitation design of the International Space Station. The project will use NASA data to record astronaut interactions with objects and spaces over time. The project expects to remedy deficiencies in previous psychological and engineering design research by taking a deep-time perspective on how a cultur ....How archaeology can transform living in space. This project aims to investigate human engagement with material culture in the extreme environment of space by applying archaeological methods to the habitation design of the International Space Station. The project will use NASA data to record astronaut interactions with objects and spaces over time. The project expects to remedy deficiencies in previous psychological and engineering design research by taking a deep-time perspective on how a culture develops in a microgravity environment. The results are intended to identify how humans adapt to space technology and can be applied in the future design of long duration space missions to maximise both survival and efficiency.Read moreRead less
Build competency aware and assuring machine learning systems. Recent development in machine learning (ML) has seen ML models with extremely high prediction accuracy. However, to support human-machine partnership in decision-making in complex environments, beyond accuracy, it is essential for ML systems to be competency aware and reliable, and at the same time be exploratory. This project aims to develop novel techniques to equip a ML system with the ability to identify own competency, to justify ....Build competency aware and assuring machine learning systems. Recent development in machine learning (ML) has seen ML models with extremely high prediction accuracy. However, to support human-machine partnership in decision-making in complex environments, beyond accuracy, it is essential for ML systems to be competency aware and reliable, and at the same time be exploratory. This project aims to develop novel techniques to equip a ML system with the ability to identify own competency, to justify its competency and decisions, to explore unknown situations and fully utilise existing expertise to deal with unknowns. The expected outcomes of the project will enable ML systems to become truely intelligent and reliable machine partners for human decision makers in a wide range of applications.Read moreRead less
Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lip ....Correlative Imaging of Brain Lipids. This project aims to develop imaging tools and protocols for the detection of lipids in brain tissue and cells. This project expects to generate advanced methodologies to display specific lipid classes and their corresponding structures within tissues and cells, with the ability to be detected and correlated with multiple techniques, which represent a currently unavailable capacity. The expected outcomes of this project are improved opportunities to study lipid biology at the cellular and sub-cellular level across a wide range of in vitro and in vivo models. The outcomes of this project should provide significant knowledge to tackle modern societal challenges in healthy ageing, brain pathologies and neurodegenerative diseases.Read moreRead less
Microbially induced calcium carbonate precipitation in different substrates. Carbonates in the form of limestone represent an important reservoir of carbon on earth. They are recorded in several natural geological formations as corals, stromatolites, beach rocks. Microbes play an important role in the formation as well as dissolution of carbonates during microbially induced calcium carbonate precipitation (MICP) reactions on different substrates in natural and built environments. Much of our kno ....Microbially induced calcium carbonate precipitation in different substrates. Carbonates in the form of limestone represent an important reservoir of carbon on earth. They are recorded in several natural geological formations as corals, stromatolites, beach rocks. Microbes play an important role in the formation as well as dissolution of carbonates during microbially induced calcium carbonate precipitation (MICP) reactions on different substrates in natural and built environments. Much of our knowledge on MICP is limited due to poor understanding of the reaction kinetics at a molecular level. This project will develop new methods to enable and advance the knowledge of MICP process with profound implications for understanding natural geological formations as well as widen the scope of current engineering applications.Read moreRead less
Quantitative Metagenomics. This project aims to revolutionize our view of the microbial world once more by transforming microbiome studies from relative counts of organisms to actual numbers of microbes. This project expects to impact all the microbiome studies that are being performed worldwide by unveiling the actual numbers of microbes. Expected outcomes of this project include new techniques to enumerate the number of bacteria in different environments and new approaches to measure gene expr ....Quantitative Metagenomics. This project aims to revolutionize our view of the microbial world once more by transforming microbiome studies from relative counts of organisms to actual numbers of microbes. This project expects to impact all the microbiome studies that are being performed worldwide by unveiling the actual numbers of microbes. Expected outcomes of this project include new techniques to enumerate the number of bacteria in different environments and new approaches to measure gene expression within individual bacteria in any environment that will be demonstrated with complex microbial communities. This should provide significant benefits because microbes affect every aspect of our lives and those effects are driven by how many microbes are present.Read moreRead less
Linking wave–sea ice feedbacks to rapid ice retreat. Antarctic sea ice extent has been in sharp decline since 2016, which is stressing the fragile Southern Ocean and Antarctic environments so vital to the global climate. This project aims to investigate a crucial candidate mechanism of sea ice loss by predicting rapid ice retreat in response to large Southern Ocean waves. New theory and modelling capabilities that account for wave–ice feedbacks will underpin the predictions, leveraging on recent ....Linking wave–sea ice feedbacks to rapid ice retreat. Antarctic sea ice extent has been in sharp decline since 2016, which is stressing the fragile Southern Ocean and Antarctic environments so vital to the global climate. This project aims to investigate a crucial candidate mechanism of sea ice loss by predicting rapid ice retreat in response to large Southern Ocean waves. New theory and modelling capabilities that account for wave–ice feedbacks will underpin the predictions, leveraging on recent research breakthroughs, including novel datasets derived from satellite and field observations. The outcomes are expected to quantify sea ice retreat due to ocean waves for the first time, with potentially major implications for coupled wave–sea ice modelling in climate studies.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less