Interactions Between Excretory-secretory Proteins Of The Carcinogenic Liver Fluke And Host Cells
Funder
National Health and Medical Research Council
Funding Amount
$489,122.00
Summary
Throughout East Asia, there is a strikingly high prevalence of cholangiocarcinoma (CCA - cancer of the bile ducts) in regions where the human liver fluke is endemic. How the parasite casues cancer is multi-factorial, but one suspected mechanism is via the secretion of parasite proteins that enter bile duct cells and cause them to proliferate. We aim to understand this process and ultimately develop new control strategies to reduce the prevalence or the infection and CCA.
Discovery Early Career Researcher Award - Grant ID: DE120100069
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The archaeology of the north coast of Bali: a strategic crossroads in early trans-Asiatic exchange. New archaeological excavations on the north coast of Bali and a comparative study of materials across Southeast Asia aim to document the growth of Trans-Asiatic exchange networks during the Late Metal Age, and particularly the strategic significance of Bali and eastern Indonesia for the trade in spices that linked Asia with the Mediterranean.
Shifting the foundations of Zoroastrian history: A fresh focus on Khorezm. This project aims to explore the importance for Zoroastrianism of images of Avestan gods in Uzbekistan. Zoroastrianism is an ancient religion, but little is known of its early development. Recent finds of massive six-metre-high murals of Avestan gods decorating the royal ceremonial centre of Akchakhan-kala in Khorezm provide evidence of early formal Zoroastrian practices, in a region not considered a centre of early relig ....Shifting the foundations of Zoroastrian history: A fresh focus on Khorezm. This project aims to explore the importance for Zoroastrianism of images of Avestan gods in Uzbekistan. Zoroastrianism is an ancient religion, but little is known of its early development. Recent finds of massive six-metre-high murals of Avestan gods decorating the royal ceremonial centre of Akchakhan-kala in Khorezm provide evidence of early formal Zoroastrian practices, in a region not considered a centre of early religious development. The project will study this data and its implications for later religious beliefs, drawing particularly on evidence for burial practices in the early Islamic period and indigenous tribal practices. The project aims to enhance understanding of one of the world’s significant religions.Read moreRead less
The archaeological and biological foundations of Southeast Asia, 2500 to 1000 BC. This project investigates the origins and ancestral migrations of the populations of Southeast Asia. It focuses on the period around 2000 BC when 'Neolithic' societies, populations and languages spread across the region. The project will examine evidence for migration, food production and population ancestry in Vietnam, the Philippines and adjacent regions.
Bronzes of Xinjiang: technology, society and power on the road to China. This project aims to reveal the backstory to the remarkable development of bronze working in ancient China by studying complex pathways by which metallurgical knowledge spread there from Eurasia through the crossroads region of Xinjiang. It will generate new knowledge through the innovative use of mass elemental analysis of ancient metals from Xinjiang, providing important evidence for early metallurgical techniques. Expec ....Bronzes of Xinjiang: technology, society and power on the road to China. This project aims to reveal the backstory to the remarkable development of bronze working in ancient China by studying complex pathways by which metallurgical knowledge spread there from Eurasia through the crossroads region of Xinjiang. It will generate new knowledge through the innovative use of mass elemental analysis of ancient metals from Xinjiang, providing important evidence for early metallurgical techniques. Expected outcomes include enhanced understanding of the role of developing technology in the consolidation of regional power and its impact on social inequality. Partnerships between Australian, Chinese and UK institutions are expected to expand Australia’s research capability in archaeology, ancient mining and metallurgy. Read moreRead less
Investigating the world's first maritime network in Pleistocene Wallacea. This project will investigate the world’s first maritime exchange network located in the islands to Australia’s north. From ~16,000 years ago, tools made from exotic obsidian (volcanic glass) appear in the archaeological assemblages of three southern Wallacean islands, as do standardised items of personal decoration and fishhooks. Where the obsidian was acquired and how far the network extended are currently unknown. This ....Investigating the world's first maritime network in Pleistocene Wallacea. This project will investigate the world’s first maritime exchange network located in the islands to Australia’s north. From ~16,000 years ago, tools made from exotic obsidian (volcanic glass) appear in the archaeological assemblages of three southern Wallacean islands, as do standardised items of personal decoration and fishhooks. Where the obsidian was acquired and how far the network extended are currently unknown. This project hopes to resolve this and determine how the network relates to other aspects of culture and changing sea levels. Through geological sourcing, geo-chemical analysis and multi-island excavations we will reveal the intensity and reach of this remarkable network to understand the origins of trade in our region. Read moreRead less
The Silk Roads in the Bronze Age: critical links between Eurasia and China. The early rise of China's great civilization owed its rapid momentum to important technological innovations that were brought in from the far distant Eurasian steppes, but almost nothing is known of how or why this process took place. The project aims to explore these questions through excavations at one of China's most important Bronze Age archaeological sites in western Xinjiang. The innovations include the cultivation ....The Silk Roads in the Bronze Age: critical links between Eurasia and China. The early rise of China's great civilization owed its rapid momentum to important technological innovations that were brought in from the far distant Eurasian steppes, but almost nothing is known of how or why this process took place. The project aims to explore these questions through excavations at one of China's most important Bronze Age archaeological sites in western Xinjiang. The innovations include the cultivation of wheat and barley, complex metallurgical techniques in bronze, silver and gold, the domesticated horse and the spoke-wheeled chariot, which became a universal weapon of war across the ancient world. The project aims to test theories of cultural transmission through interactive GIS modelling of environment and land use potential.Read moreRead less
Landscape, resources and human migration during the Southeast Asian Neolithic. The Southeast Asian Neolithic (2500 to 500 BC) was a time of powerful linguistic and biological expansion, especially amongst those early agricultural societies that surrounded the South China Sea. This project will concentrate on: reconstructing the landscapes of Neolithic settlement, greatly different from the vast lowland alluvial landscapes that feed such concentrated populations today; reconstructing the economy ....Landscape, resources and human migration during the Southeast Asian Neolithic. The Southeast Asian Neolithic (2500 to 500 BC) was a time of powerful linguistic and biological expansion, especially amongst those early agricultural societies that surrounded the South China Sea. This project will concentrate on: reconstructing the landscapes of Neolithic settlement, greatly different from the vast lowland alluvial landscapes that feed such concentrated populations today; reconstructing the economy of Neolithic food production, especially the archaeological histories of the major crops and domestic animals; and, reconstructing and comparing the material culture of the initial Neolithic, with its immense network of population expansion involving China, Southeast Asia and Oceania. Read moreRead less