Pathophysiology And Alternative Preventative Strategy For Breast Cancer Chemotherapy-induced Bone Loss
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Combination cytotoxic chemotherapy is the current optimal approach for treating breast cancer in premenopausal women. However, long-term skeletal defects (osteoporosis and fractures) caused by the chemotherapy have become an increasingly serious problem due to its intensified use and improved patient survival rate. This project seeks to elucidate the mechanisms for chemotherapy-induced bone defects and to initiate development of a preventative treatment using natural bioactive micronutrients.
The role of the immune system in pain is emerging from recent discoveries, and may hold the key to novel pain treatments. Most people experience brief gut infections from food or contagion without long-term consequences. Many others suffer symptoms for years afterwards - probably the best example of immune-based pain. Our project investigates how immune cells communicate with sensory nerves, and how these communications change from both angles after gut infection or inflammation.
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
Ion Channels Underlying Inflammatory And Post-inflammatory Visceral Mechanical Hypersensitivity
Funder
National Health and Medical Research Council
Funding Amount
$453,439.00
Summary
Inflammation causes tissue damage that triggers ion channels within sensory nerve fibres to produce greater signals in response to mechanical events, causing acute pain. In chronic pain, although the inflamed tissue has healed, sensory nerve fibres fail to "reset" back to normal. Often chronic pain is more severe than acute pain. This project will identify which ion channels are responsible for signalling acute and chronic visceral pain, explaining why sensory nerve fibres fail to reset.
Effective and efficient corporate tax enforcement. This project uses economic theory and experimental tests in order to inform tax authorities on how to best audit tax receipts from corporations. The project will result in advice on how audit resources should be allocated across firms, if minimising corporate tax evasion and at the same time maximising social welfare are the authority's objective.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100079
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered o ....A thermally stratified Sea-Ice-Wave Interaction Facility. A thermally stratified sea ice wave interaction facility: Predictions of climate change now impact all levels of society as future political, social and environmental plans are made on the basis of these models. Predictions require models of many complex dynamical processes with a wide range of parameters. An important process is the Marginal Ice Zone (MIZ) dynamics. The MIZ is the region between the open ocean and the fully ice-covered ocean where waves and ice interact, causing ice-breaking and wave attenuation. This unique facility will enable experiments in sea-ice-wave interactions in a controlled environment. Water and air temperature, thermal stratification, water waveform and ice properties will be adjusted in order to preserve key characteristics of the complex ocean environment.Read moreRead less
Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits a ....Dead Heart Beating? Landscape, Climate and People in Desert Australia. This project aims to undertake the first detailed investigation of the archaeology, landscape history and paleoenvironment of dryland lakes in the Simpson, Strzelecki and Stuart Stony Deserts in Central Australia. Using cutting edge methods, the project expects to discover new archaeological sites, provide a new climate record for inland Australia and develop innovative new analytical and field techniques. Expected benefits also include the development of new cutting-edge methodologies for the investigation of Australian desert landscapes, comprehensive baseline data of how this region has evolved prior to European colonization and resolving why no Pleistocene aged archaeological sites have been found in the region.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100220
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Sonic drilling to provide contamination-free core sampling of rock and unconsolidated sediment. Australia is the world's driest inhabited continent. Understanding environmental and climatic changes, from the temperate period when humans arrived about 50,000 years ago to the present state of widespread aridity, is crucial for modelling future climate change. This facility will provide new generation drilling equipment which is necessary to obtain accurate records.
Palaeoclimate reconstructions from the isotopic signatures of fossilised leaf waxes. This project develops a method for using the chemical signature of fossilised leaf waxes to reconstruct hydrologic change in south-eastern Australia during the Holocene (last 10,000 years) and Eocene (56-34 million years ago). Understanding climate in the geologic past is essential for testing models and projecting future climate with rising carbon dioxide.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100028
Funder
Australian Research Council
Funding Amount
$3,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes ....Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes include understanding past global environmental change on multiple time scales, the deep biosphere, plate tectonics, formation and distribution of resources, and generation of hazards. These outcomes are paramount to Australia’s national science and research priorities, and societal and economic prosperity.Read moreRead less