Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in sit ....Switchable and stereocontrolled photoredox catalysis. This project aims to develop new catalytic synthetic reactions for the rapid and more direct functionalisation of organic compounds under mild conditions with the use of visible light. An integrated experimental and computational approach will be used to design potent visible-light photocatalysts that retain the advantages of standard photoredox catalysis but with the added ability to intercept and, thus control, reactive intermediates in situ. This will enable the control of stereochemistry in photoredox reactions – not possible with standard catalysts - and establish other useful synthetic transformations. These strategies will make it easier to prepare valuable classes of organic molecules – efficiently, safely, and cost-effectively.
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Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian po ....Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian population. Accurate and objective per-capita based consumption and release estimates for a wide range of chemicals is intended to provide a baseline against which to measure changes in our chemosphere.Read moreRead less
ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ....ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ultimately harness the Grid, enabling linkage into other national and international Grid systems. Encompassing physics, computer science, applied mathematics, chemistry and biochemistry, and catalysing interaction across these disciplines, the MMSN will impact all five National Research Priority 3 goals.Read moreRead less
Polymer nanoparticles and their assembled supracolloidal monolithic structures for applications in separation science. This project will generate new polymeric materials that will improve the analysis of complex samples. This will be applied in a wide range of areas of national importance including: pharmaceutical analysis and drug discovery; environmental, clinical and forensic analysis; and energy generation and foods.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100129
Funder
Australian Research Council
Funding Amount
$249,000.00
Summary
Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution ma ....Microflow ultra high pressure liquid chromatography - high resolution mass spectrometry for chemical exposure monitoring. Microflow ultra high pressure liquid chromatography – high resolution mass spectrometry for chemical exposure monitoring: Identifying new chemicals of interest in environmental or biological samples is the first critical step toward understanding their impact to human and environment. A state-of-the-art microflow ultra high performance liquid chromatography high resolution mass spectrometer is fundamental to extend our research capabilities to new environmental contaminants and environmental exposure biomarkers, as well as consumption biomarkers of new illicit drugs and their metabolites. This instrument will fill an important gap in our capacity to link health/ecological risk to unknown chemicals and will allow interdisciplinary researchers to advance work in environmental toxicology, chemistry and forensics.Read moreRead less
Hierarchically porous polymer monoliths for separation science. Understanding the molecular composition of biomarkers involved in cell-cell communication and the fate of nanoparticles in the environment is critical to improve our understanding of diseases and environmental processes. This project will develop a new approach for the design of separation media that will greatly improve the efficiency of techniques used to analyse these complex samples. The separation media will consist of a polyme ....Hierarchically porous polymer monoliths for separation science. Understanding the molecular composition of biomarkers involved in cell-cell communication and the fate of nanoparticles in the environment is critical to improve our understanding of diseases and environmental processes. This project will develop a new approach for the design of separation media that will greatly improve the efficiency of techniques used to analyse these complex samples. The separation media will consist of a polymer containing large flow-through pores as well as well-defined mesopores. This dual porous skeleton will allow for the size-based separation of biomarkers and nanoparticles. The new separation media will enable the development of new technologies with applications in areas such medicine and environmental science.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100183
Funder
Australian Research Council
Funding Amount
$715,000.00
Summary
An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectr ....An ICP-ToF-MS facility for environmental, mineral and biological science. This project aims at establishing a facility for the detection, quantification and rapid mapping of elements and their isotopes in nanoparticles and a diverse set of biological and earth materials. The facility consists of a latest generation ICP-ToF-MS that can simultaneously collect a full suite of isotopic information (Li to U) from liquid samples or, in combination with laser ablation and laser induced breakdown spectroscopy, solid samples. It will enhance capabilities and sample throughput in environmental science, geoscience, biology and cultural heritage research, significantly accelerating the discovery of new ore bodies, improving environmental risk assessment and assisting research in cancer biology.Read moreRead less
Assessment of bentonites as remediating agents for metal contaminated soils using innovative bioavailability reduction technology. The project seeks to carry out research on innovative, economically sustainable risk-based solutions (soil amendments) for metal-contaminated soils and methods for assessing the potential risk/bioavailability of soil bound metals. The work will determine factors affecting the reactivity, mobility and bioavailability of metals in Australian soils and clays and method ....Assessment of bentonites as remediating agents for metal contaminated soils using innovative bioavailability reduction technology. The project seeks to carry out research on innovative, economically sustainable risk-based solutions (soil amendments) for metal-contaminated soils and methods for assessing the potential risk/bioavailability of soil bound metals. The work will determine factors affecting the reactivity, mobility and bioavailability of metals in Australian soils and clays and methods by which these can be controlled. Remediation options, such as natural clay amendments to reduce metal bioavailability, will be assessed against in vivo and in vitro bioavailability assays in order to develop cost effective, risk-based remediation strategies and assessment protocols for urban and rural contaminated soils.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100040
Funder
Australian Research Council
Funding Amount
$4,997,903.00
Summary
ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence- ....ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence-informed decision-making, and regulatory framework development. FAAB graduates will lead and deliver future national self-reliance to the Australian bioactives sector, increasing diversification and international competitiveness and development of regulation in a growing market. Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC140100022
Funder
Australian Research Council
Funding Amount
$2,148,935.00
Summary
ARC Training Centre for Portable Analytical Separation Technologies. ARC Training Centre for Portable Analytical Separation Technologies. Portable analytical separation systems will enable point-of sample analysis for complex samples in food, environmental and clinical applications. The Training Centre aims to train the next generation of industry-ready Australian researchers through creating a sustainable research partnership between university-based researchers and Australian industry focused ....ARC Training Centre for Portable Analytical Separation Technologies. ARC Training Centre for Portable Analytical Separation Technologies. Portable analytical separation systems will enable point-of sample analysis for complex samples in food, environmental and clinical applications. The Training Centre aims to train the next generation of industry-ready Australian researchers through creating a sustainable research partnership between university-based researchers and Australian industry focused on developing new capabilities and technologies that have the potential to facilitate, support, or catalyse the progressive deployment of portable separation science technologies into society. This will enable the development of new, portable and affordable analytical separation systems and contribute to creating a sustainable, globally competitive manufacturing industry in Australia.Read moreRead less