The mathematics of novel magnetic memory materials. Magnetic memories are the world’s principal device for storing information. The next generation will have greatly increased access speed and data-storage capacity. This project will develop the mathematical theory of these new magnetic memory materials, a crucial first step in understanding and being able to fine-tune their properties.
Mathematical and Numerical Models of Piezoelectric Wave Energy Converters. The project will investigate piezoelectric wave energy converters. We will derive the equations of motion in a form suitable for use in marine engineering paradigms using variational methods and then solve these analytically and with smoothed particle hydrodynamics. Using these innovative techniques, this project will generate new knowledge capable of elucidating the multifaceted physical phenomena that occur when comple .... Mathematical and Numerical Models of Piezoelectric Wave Energy Converters. The project will investigate piezoelectric wave energy converters. We will derive the equations of motion in a form suitable for use in marine engineering paradigms using variational methods and then solve these analytically and with smoothed particle hydrodynamics. Using these innovative techniques, this project will generate new knowledge capable of elucidating the multifaceted physical phenomena that occur when complex fluid motion and deformable structures interact. The project outcomes include the development of mathematical and computation methods to handle intricate behaviours of piezoelectric elastic-fluids systems. These groundbreaking methods will allow these wave energy systems to be analysed and their effectiveness assessed.Read moreRead less
Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA. Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. ....Dinuclear Ruthenium Complexes as Sequence- and Structure-Selective Binding Agents for DNA. Studies of the interaction of mononuclear metal complexes with DNA have greatly increased our understanding of the ways that small molecules recognise particular sites on DNA. However, in order to design drugs that target specific genes, and hence be potentially capable of controlling gene expression, it is necessary to study the binding of metal complexes that can associate with larger segments of DNA. Using the combined expertise of the applicants, it is proposed to stereospecifically synthesise dinuclear complexes and study their DNA binding. This will greatly assist in the development of drugs that can selectively target genes and altered DNA.Read moreRead less
Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy ....Mechanistic Studies on Biologically Active Iron Chelators. The need for orally effective drugs as alternatives to invasive treatment regimens such as subcutaneous infusion is an ongoing concern in health care. This is particularly true in people suffering iron overload. In many cases this condition is present at birth and thus the administration of vital iron chelation therapy via the oral route is a much preferred option. We have unearthed a novel series of candidates for iron chelation therapy (the pyridine-2-carboxaldehyde isonicotinoyl hydrazone [PCIH] analogues) which show oral activity. These chelators undergo some interesting iron catalysed oxidation chemistry and it is vital that the mechanism of this reaction be elucidated to determine whether it will be of biological significance upon administration of these compounds as iron chelators.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775676
Funder
Australian Research Council
Funding Amount
$290,000.00
Summary
An X-ray Diffraction Facility for Molecular Structure Determination. Characterisation of new chemical compounds demands proof of molecular structure. Whether for the identification of a new drug candidate, a material with novel properties or in the exploration of previously unknown types of compounds, X-ray crystallography is the definitive technique for this purpose. This proposal is for an X-ray diffractometer that will significantly enhance the capabilities of all synthetic and natural produc ....An X-ray Diffraction Facility for Molecular Structure Determination. Characterisation of new chemical compounds demands proof of molecular structure. Whether for the identification of a new drug candidate, a material with novel properties or in the exploration of previously unknown types of compounds, X-ray crystallography is the definitive technique for this purpose. This proposal is for an X-ray diffractometer that will significantly enhance the capabilities of all synthetic and natural products chemistry research programs undertaken at the Universities of Queensland and Newcastle, all currently in receipt of ARC funding. This research is aligned with the ARC National Research Priorities, of Promoting and Maintaining Good Health and Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tack ....New Synthetic Routes to the Immobilisation of Mixed Valence Transition Metal Complexes on Conducting Metal Oxides. Highly coloured, electrochemically active transition metal dyes may find application electrochromic devices, where they may switch between contrasting coloured forms through a simple redox reaction. A prerequisite is that the dye be immobilised onto a solid conducting support whilst preserving the electrochemical and optical properties of the dye found in solution. This project tackles this problem through a combination of organic and inorganic synthesis to develop new electrochromic dyes that may be attached to mesoporous titania.Read moreRead less
Nanostructures of Titanium Dioxide and Titanates by Wet-chemistry. One-dimensional (1D) nanoparticulates of titanium dioxide (TiO2) and titanate synthesized by wet-chemistry approaches are new advanced materials of unusual properties. This project will investigate the formation and phase transition mechanism of these 1D particulates by various techniques. With such knowledge, we can effectively control the morphology on a scale of nanometers, and tailor the energy gap of these materials. This wi ....Nanostructures of Titanium Dioxide and Titanates by Wet-chemistry. One-dimensional (1D) nanoparticulates of titanium dioxide (TiO2) and titanate synthesized by wet-chemistry approaches are new advanced materials of unusual properties. This project will investigate the formation and phase transition mechanism of these 1D particulates by various techniques. With such knowledge, we can effectively control the morphology on a scale of nanometers, and tailor the energy gap of these materials. This will significantly influence the photosemiconductive photocatalytic and lithium ions insertion behaviours of the particles so that advanced materials for solar energy conversion, photocatalysts for decomposing organic pollutants in environment, eletrode materials of lithium batteries can be developed.Read moreRead less