Development And Population-based Validation Of Hierarchical Adaptive Mental Health Screeners
Funder
National Health and Medical Research Council
Funding Amount
$391,710.00
Summary
Although 45% of all Australians will experience a lifetime mental disorder, methods to identify mental health problems are inadequate. This project will develop and validate new mental health screening tools, building on a new generation of screeners developed in the US. These screeners will be tailored to the individual, resulting in highly precise and flexible assessment tools. The screeners will be tested in a large community survey, forming the basis for future tailored mental health service ....Although 45% of all Australians will experience a lifetime mental disorder, methods to identify mental health problems are inadequate. This project will develop and validate new mental health screening tools, building on a new generation of screeners developed in the US. These screeners will be tailored to the individual, resulting in highly precise and flexible assessment tools. The screeners will be tested in a large community survey, forming the basis for future tailored mental health services.Read moreRead less
Risk Stratification Of Older People In Hospital: Validation And Influence On Clinical Decision Making
Funder
National Health and Medical Research Council
Funding Amount
$291,067.00
Summary
Older people in hospital are at high risk of adverse outcomes, a vulnerability commonly referred to as frailty. In community-dwelling older people, frailty status can be measured precisely with a Frailty Index score. This research aims to develop a Frailty Index from a standardised comprehensive geriatric assessment instrument used in the routine care of many patients in hospital. This would assist clinicians to identify vulnerable older inpatients, improving their care in the acute setting.
Designing Radiation-Tolerant Reconfigurable Systems for Space. The processing speed, cost and flexibility requirements of future satellite-based applications cannot be satisfied with conventional radiation-hardened processors or custom integrated circuits. This project aims to develop key technology to enable off-the-shelf hardware to be customised for this use without compromising reliability. The project aims to develop the design methods needed to implement a given set of satellite applicatio ....Designing Radiation-Tolerant Reconfigurable Systems for Space. The processing speed, cost and flexibility requirements of future satellite-based applications cannot be satisfied with conventional radiation-hardened processors or custom integrated circuits. This project aims to develop key technology to enable off-the-shelf hardware to be customised for this use without compromising reliability. The project aims to develop the design methods needed to implement a given set of satellite applications on a processing platform composed of application-specific soft processors and accelerator circuits hosted on conventional reconfigurable logic devices. Crucially, the solution architecture is expected to be sufficiently hardened against radiation-induced errors while meeting performance and circuit area constraints.Read moreRead less
Validating Novel Biomarkers Relevant To Major Depression
Funder
National Health and Medical Research Council
Funding Amount
$515,550.00
Summary
Depression prevention and treatment are public health priorities; therefore, it is critical to improve and personalise treatments, which can only be achieved by advancing knowledge of its underlying biology. This research project will contribute to validating potentially relevant genes for MDD risk or antidepressant response and to provide the scientific foundation for future strategies to test their products as MDD biomarkers in the clinical setting.
Development And Validation Of A Latent Tuberculosis Diagnostic
Funder
National Health and Medical Research Council
Funding Amount
$534,865.00
Summary
Globally, tuberculosis is a leading cause of death with 9.6 million new diagnoses in 2014. The diagnosis of latent TB infection is important, but is difficult to make because current assays are suboptimal. We have developed a very simple assay which detects responses to TB antigens by co-expression of two surface markers expressed by CD4+ T cells. We propose to develop this into a highly standardised kit for the diagnosis of TB with our commercial partner Cytognos.
Validation Of A Multiplexed Blood Based Screening Assay For The Diagnosis Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$556,712.00
Summary
Colorectal cancer (CRC) is the second most common cancer in Australia with poor patient outcome due to late detection of the disease. We have developed a simple blood based test that can diagnose individuals with CRC at an early stage when the chance of cure is greater than 80%.
The Validity Of ‘8 Instruments’ Used To Include Quality Of Life In Economic Evaluation In 8 Disease Areas And 6 Countries
Funder
National Health and Medical Research Council
Funding Amount
$856,212.00
Summary
The Quality of Life is incorporated in the economic evaluation of health services using different ‘utility instruments’. Small scale comparative studies reveal large discrepancies between measurements. Very few studies combine multiple utility and disease specific instruments and to date no studies have compared utility instruments with scales measuring subjective wellbeing (happiness) or human capabilities. This project will mount the largest cross national survey to date of these questions.