Postviral Wheezing In Childhood: Disregulation Of Airway Tone?
Funder
National Health and Medical Research Council
Funding Amount
$577,040.00
Summary
Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. Ho ....Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. However, many infants who wheeze with viral infections, especially in the first year of life, do not develop allergies in later life, raising the possibility that they did not have the same type of asthma as those whose symptoms persist. This project will study the effects of viral infections on lung function to determine whether particular types of virus can have detrimental effects of lung function lasting for years. We will also examine whether the age at which the infection occurs and the severity of the infection influence the long-term outcome. The project involves studying infants during the recovery phase of respiratory viral infections, older children years after documented infections and experimental animal models that have been infected under controlled conditions. By determining whether respiratory viral infections can have long-term effects on lung function that can mimic asthma, we will advance our understanding of how asthma develops. In addition, specific treatment and preventative strategies could then be developed to prevent these long-term abnormalities, instead of relying on asthma medication (especially inhaled corticosteroids) as is the current practice. Preventative strategies could include encouraging the development of specific vaccines.Read moreRead less
Ontology Based Multisite Distributed Software Development. Increasingly clients in cities are developing software overseas or in regional centres. The participating companies have found existing centralized software engineering techniques inadequate for multisite development. This project produces new principles and techniques for multisite distributed software development. Thus it proposes a new methodology, a new project management approach, a new workflow tracking technique and a new concept ....Ontology Based Multisite Distributed Software Development. Increasingly clients in cities are developing software overseas or in regional centres. The participating companies have found existing centralized software engineering techniques inadequate for multisite development. This project produces new principles and techniques for multisite distributed software development. Thus it proposes a new methodology, a new project management approach, a new workflow tracking technique and a new concept of software object/component that allows differentiated access. A platform is also developed for use in field studies for validation and benchmarking. The results will help Australia become a provider of software services for international clients and permit devolution to regional centres.Read moreRead less
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Discovery Early Career Researcher Award - Grant ID: DE170101081
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis t ....Adaptive value-flow analysis to improve code reliability and security. This project aims to develop client-driven adaptive value-flow analysis to detect software bugs in system software written in the C/C++ programme language. Static analysis tools for automated code inspections can benefit software developers, but are imprecise, inefficient and not user-friendly for analysing real-world industrial-sized software. The project will investigate static, dynamic and user-guided value-flow analysis to efficiently and precisely analyse large-scale programs according to clients’ needs, thereby allowing compilers to generate safe, reliable and secure code. This project is expected to advance value-flow analysis for industrial-sized software, improve software reliability and security, and benefit Australian software systems and industries.Read moreRead less
Automation of metric temporal reasoning. A major contemporary engineering concern is to ensure the predictable and robust operation of computer systems involving software, hardware, and human users. The need for systematic and careful construction of such systems requires the development of formal methods based on a dense view of time rather than the traditional step-by-step models.
automated strategic reasoning. Formal methods are used to ensure robust correct behaviour in design and implementation of computer systems. Traditional models of computer operation involve a linear sequence of behaviour but today’s systems are complex interactions between many components including the environment of the system and human users. Thus analysis is done via a logical game between components where each is trying to meet its specified requirements regardless of what others do: formalis ....automated strategic reasoning. Formal methods are used to ensure robust correct behaviour in design and implementation of computer systems. Traditional models of computer operation involve a linear sequence of behaviour but today’s systems are complex interactions between many components including the environment of the system and human users. Thus analysis is done via a logical game between components where each is trying to meet its specified requirements regardless of what others do: formalisms include branching time and competing coalitions of agents. This project is to take early advantage of recent breakthroughs in automated logical reasoning with such models by the investigator to deliver general practical techniques of system development and verification.Read moreRead less
Formal Specification and Realisation of Dynamic Reconfiguration in FPGA-based Systems. The project aims are:
to significantly advance our understanding of the key concepts needed to successfully exploit dynamic, run-time reconfigurable computing, a technology that is now becoming increasingly available due to developments in FPGA (Field Progammable Gate Array) devices, and
the development of an innovative high-level programming environment that will include a language, associated design method ....Formal Specification and Realisation of Dynamic Reconfiguration in FPGA-based Systems. The project aims are:
to significantly advance our understanding of the key concepts needed to successfully exploit dynamic, run-time reconfigurable computing, a technology that is now becoming increasingly available due to developments in FPGA (Field Progammable Gate Array) devices, and
the development of an innovative high-level programming environment that will include a language, associated design methodologies, compilation techniques, and run-time support that will make dynamic reconfigurable computing accessible to a wide community of potential users.
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The Long-term Consequences Of Assisted Reproduction On The Growth, Metabolic, Respiratory, Psychological, Immunological And Reproductive Development Of The Offspring.
Funder
National Health and Medical Research Council
Funding Amount
$1,552,096.00
Summary
1 in 25 children are born from IVF treatment - incredibly- to our shame; no data exists as to the long-term health of these children. Presented is a unique opportunity, which would be exceedingly difficult to replicate elsewhere in the world, to determine the long-term consequences of IVF upon the development of the offspring, by comparing their growth, metabolic, respiratory, psychological, immunological and reproductive development to a representative sample of WA children- the Raine cohort.
Tools, methodologies and reasoning support for developing companion-toy modules. This project investigates building of modules for an intelligent Toy which can be customised and adapted over time by add-on modules. Intelligent interactive toys are growing in popularity, and the ability for such a toy to develop over a prolonged lifetime, is both a sound business idea and a mechanism for extending the useful life of the Toy.
Novel Bioinformatics approaches for genetics and data linkage. The research project will involve creation of novel data and communications formats to fulfil the vital task of integrating the vast heterogeneous biological resources available. We will apply this new infrastructure to a large data linkage project. In parallel, we will undertake methodological research in informatics to design high throughput research methods and tools to analyse and visualise genetic data. These will be applied to ....Novel Bioinformatics approaches for genetics and data linkage. The research project will involve creation of novel data and communications formats to fulfil the vital task of integrating the vast heterogeneous biological resources available. We will apply this new infrastructure to a large data linkage project. In parallel, we will undertake methodological research in informatics to design high throughput research methods and tools to analyse and visualise genetic data. These will be applied to linkage disequilibrium mapping and haplotyping in human, animal and plant diseases. Improving informatics integration and designing novel methods and implementations of algorithms will be beneficial to local and international researchers in a range of fields.Read moreRead less