Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed b ....Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed by academics. We hypothesise that current 3D relational visualization methods fail because they do not pay attention to the human perception of topology. In this project we will leverage mathematical topology to construct new methods for the 3D visualization of relational data.
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New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive f ....New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive feedback loop in the course of research into both topics.Read moreRead less
ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand add ....ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand addresses issues about methodology, modelling toolkits, and management and control. Practical applications are advanced via collaborative projects that address key issues in biology, environment, and socio-economics.Read moreRead less
Comparative Biogeography of Australasian biota. Establishing an internationally recognised biogeographical research program will help scientists, policy makers and the public understand the past and future distribution patterns of the plants and animals of Australia. Discovering these patterns will help conservation biologists and government implement the right policies and practices to deal with biodiversity loss and climate change.
Genetic variation of transcriptional control. Genetic variation is a key cause phenotype differences in humans, animals, and plants and so of great economic importance. Despite its proven importance to human diseases, ?quantitative? variation in the amount of gene expression rather than ?qualitative? protein sequence changes, has not been systematically studied. We have developed a powerful method to identify genetic causes of quantitative variation using crosses of inbred mice in conjunction wi ....Genetic variation of transcriptional control. Genetic variation is a key cause phenotype differences in humans, animals, and plants and so of great economic importance. Despite its proven importance to human diseases, ?quantitative? variation in the amount of gene expression rather than ?qualitative? protein sequence changes, has not been systematically studied. We have developed a powerful method to identify genetic causes of quantitative variation using crosses of inbred mice in conjunction with microarray techniques to analyse expression of thousands of genes simultaneously. These studies will be extended to humans and be significant to wide areas of biological and commercial activity.Read moreRead less
Computer simulation techniques to reduce the incidence of femoral fracture after hip replacement surgery. Australia's ageing population is driving an increase of 5% to 10% a year in the number of primary total hip replacements. We will move beyond conventional surgical techniques, to deliver the science for an accurate, reliable computer-based system that is significantly more accurate and reliable. Optimising implant selection criteria to better match patients' activity levels and bone physiolo ....Computer simulation techniques to reduce the incidence of femoral fracture after hip replacement surgery. Australia's ageing population is driving an increase of 5% to 10% a year in the number of primary total hip replacements. We will move beyond conventional surgical techniques, to deliver the science for an accurate, reliable computer-based system that is significantly more accurate and reliable. Optimising implant selection criteria to better match patients' activity levels and bone physiology and minimise revision rates; this has major implications for the national health budget and patients' quality of life. Our advances will allow the implementation of improved surgical techniques that minimise the risk of implant related bone failure.Read moreRead less
Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. ....Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. This will lead to new personal diagnostics tools for rapid genotype profiling, to better tailor therapy to the individual patient's specific characteristics. As well as the potential to improve health outcomes, the project will generate significant intellectual property and the opportunity for development of new diagnostic instrumentation in Australia.Read moreRead less
Novel methods for detecting changes in soft tissue microstructure and biomechanical properties using multi-modality MR imaging. This project will lead to novel methods for studying the internal structure of the soft tissues of the body, such as muscles and brain tissue, and how this is affected by mechanical loading and disease states. The project will thoroughly validate these new methods. This will not only provide new techniques for research use, but lead to improved diagnostic techniques in ....Novel methods for detecting changes in soft tissue microstructure and biomechanical properties using multi-modality MR imaging. This project will lead to novel methods for studying the internal structure of the soft tissues of the body, such as muscles and brain tissue, and how this is affected by mechanical loading and disease states. The project will thoroughly validate these new methods. This will not only provide new techniques for research use, but lead to improved diagnostic techniques in the future.Read moreRead less
Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for ....Mathematical and mechanical models in nano-engineering and nanomedicine. The major environmental problems generated from global warming and the major human health problems, like cancer and diabetes, if they are to be solved at all, will most likely be resolved making use of advances in nanobiotechnology. This proposal will position Australia as a leader in the modelling of nanodevices such as gigahertz oscillators, nano-electromagnets, nanosensors, nanosyringes and nanoporous media suitable for hydrogen storage and gas separation, which will lead to new technologies and commercial spin-offs that will be of major benefit to this country. The applicants will develop a range of topics in nano-engineering and nanomedicine, training a team that will provide the next generation of researchers in these vital areas.Read moreRead less
Thermo-electro-chemo-mechanical properties of biological systems. The proposal is aimed at developing a new theoretical framework for piezoelectric biological materials and structures, through theoretical analysis, computation and numerical simulations, as well as experimental investigations, to produce high-reliability, high-performance hydrogel components and smart soft tissue structures. It is envisaged that successful outcomes of this program will give the Australian biological industry a te ....Thermo-electro-chemo-mechanical properties of biological systems. The proposal is aimed at developing a new theoretical framework for piezoelectric biological materials and structures, through theoretical analysis, computation and numerical simulations, as well as experimental investigations, to produce high-reliability, high-performance hydrogel components and smart soft tissue structures. It is envisaged that successful outcomes of this program will give the Australian biological industry a technology edge over their competitors and provide easy-to-use guidelines for the design of smart biological systems.Read moreRead less