Drug particle characterisation. The understanding of drug particle characterizations is one of the key issues in the development of novel nasal sprayers for targeted drug delivery. A comprehensive study is proposed for characterising drug formation in sprayers and particle deposition in nasal cavity using the latest experimental and numerical techniques. A computer-aided design technology will be developed to optimise drug delivery systems. The new technology has great potentials leading to the ....Drug particle characterisation. The understanding of drug particle characterizations is one of the key issues in the development of novel nasal sprayers for targeted drug delivery. A comprehensive study is proposed for characterising drug formation in sprayers and particle deposition in nasal cavity using the latest experimental and numerical techniques. A computer-aided design technology will be developed to optimise drug delivery systems. The new technology has great potentials leading to therapeutic and economic benefits in developing advanced/innovative drug delivery systems and in evaluating the potential biological effects by the drugs to be introduced through the nose.Read moreRead less
OPTIMIZED NASAL DRUG DELIVERY SYSTEMS -- COMPUTER AIDED DESIGN. The aim of this project is to develop a computer-aided design technology to assist in targeted drug delivery through the human nasal cavity which is being recognised to be an excellent alternative route for the administration of medication drugs. The aim will be achieved by conducting computer modelling of nasal flow under realistic physiological conditions and by performing experimental measurements and testing to validate computer ....OPTIMIZED NASAL DRUG DELIVERY SYSTEMS -- COMPUTER AIDED DESIGN. The aim of this project is to develop a computer-aided design technology to assist in targeted drug delivery through the human nasal cavity which is being recognised to be an excellent alternative route for the administration of medication drugs. The aim will be achieved by conducting computer modelling of nasal flow under realistic physiological conditions and by performing experimental measurements and testing to validate computer models. The new technology has great potentials leading to therapeutic and economical benefits in developing advanced/innovative drug delivery systems and in evaluating the potential biological effects by the drugs to be introduced through the nose.Read moreRead less
Developing a Hemodynamic Model for Improving Clinical Treatment of Vascular Diseases. Stroke caused by vascular diseases is the second greatest single killer, which is taking away thousands of lives and costing billions every year in Australia. Improving the existing clinical treatments of these diseases is thus of utmost urgency. This project is targeted to developing a reliable Hemodynamic model through comprehensive experimental validation approach. It will not only foster a more in-depth res ....Developing a Hemodynamic Model for Improving Clinical Treatment of Vascular Diseases. Stroke caused by vascular diseases is the second greatest single killer, which is taking away thousands of lives and costing billions every year in Australia. Improving the existing clinical treatments of these diseases is thus of utmost urgency. This project is targeted to developing a reliable Hemodynamic model through comprehensive experimental validation approach. It will not only foster a more in-depth research of vascular diseases but also provide a virtual forecasting tool for physicians or surgeons to develop guidance on diagnosis and therapeutic planning of clinical treatment, which brings great socio-economic benefit to the health of the Australian community.Read moreRead less
Final frontier in computational modelling of movement. This project aims to create the computational models and methods needed to advance current understanding of musculoskeletal function during movement. Humans must maintain their capacity to move in order to maintain quality-of-life. Predictive modelling is potentially the most powerful approach for understanding musculoskeletal function during movement. Current computational methods are too slow and unreliable to deliver predictive simulation ....Final frontier in computational modelling of movement. This project aims to create the computational models and methods needed to advance current understanding of musculoskeletal function during movement. Humans must maintain their capacity to move in order to maintain quality-of-life. Predictive modelling is potentially the most powerful approach for understanding musculoskeletal function during movement. Current computational methods are too slow and unreliable to deliver predictive simulations of movement using realistic models of muscle and joint anatomy. This project expects to create the next generation of methods and algorithms needed to enable predictive modelling of movement. Predictive simulations will provide new insights into how muscles stabilise and control movements of the spine, pelvis and lower limbs during daily activities such as walking.Read moreRead less
Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tiss ....Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tissue, and quantitatively explain how wear is minimised in cartilage through weeping lubrication. This model will progress our understanding of cartilage mechanics in health and disease, and so help Australians age well and productively.Read moreRead less
A new energy absorption system for brain injury mitigation. This research aims to propose and investigate a next generation high-energy absorbing helmet pad that will protect the Australian Defence Force soldiers against both ballistic and blast threats. New fundamental knowledge in the area of high-energy absorbing metamaterials will be obtained by using numerical modelling and experimental studies. The expected outcomes of the project include the development of a new wearable energy absorbing ....A new energy absorption system for brain injury mitigation. This research aims to propose and investigate a next generation high-energy absorbing helmet pad that will protect the Australian Defence Force soldiers against both ballistic and blast threats. New fundamental knowledge in the area of high-energy absorbing metamaterials will be obtained by using numerical modelling and experimental studies. The expected outcomes of the project include the development of a new wearable energy absorbing pad which can be used as the next generation combat helmet liners and accessories. The novel high-performance energy absorption system will have a wide range of direct applications in future personal armour, as well as sports gears and elderly healthcare products.Read moreRead less
Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation ....Multi-scale modeling of transport through deformable porous materials. Understanding solute transport through porous materials is essential because it provides a technical basis for answering many important questions in society today-how can humans avoid 'brittle bones', how to design durable infrastructure, how to safely store wastes (e.g. hazardous and municipal). Solution of each of these problems requires innovation in model development, new method of analysis, and insightful interpretation of results. While theoretical developments of this project are general, in the sense that they are not restricted to particular engineering disciplines, the four chosen applications closely align with two major research priorities namely An Environmental Sustainable Australia and Promoting and Maintaining Good Health.Read moreRead less
Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system ....Quantitative micro-computed tomography for mechanobiological measurement. This project aims to investigate novel measurement approaches for complex cartilage and joint systems by utilising engineering and software design, imaging physics and musculoskeletal biology. Accurate measurement of these living biological systems in action expects to generate new knowledge and a fundamental understanding of their mechanobiological processes. This project will enhance understanding of this complex system and facilitate our capacity to innovate functional solutions in biomedical engineering and biosciences.Read moreRead less
Influence of electromagnetic emissions from mobile phones on nervous function in the human brain and heart. This research will investigate the influence of mobile phone electromagnetic exposures on the nervous function of the human brain and heart. Brain activity will be monitored by EEG recordings, and heart function will be measured by blood pressure and ECG. As far as possible the methodologies employed will be consistent with previous reported studies in order to allow comparisons, and use ....Influence of electromagnetic emissions from mobile phones on nervous function in the human brain and heart. This research will investigate the influence of mobile phone electromagnetic exposures on the nervous function of the human brain and heart. Brain activity will be monitored by EEG recordings, and heart function will be measured by blood pressure and ECG. As far as possible the methodologies employed will be consistent with previous reported studies in order to allow comparisons, and use standardised quantifiable metrics so that the biological significance of the data can be meaningfully interpreted. The outcomes of this project will address uncertainties in the present data which are of concern to national and international regulatory and health agencies.Read moreRead less
Intelligent Freeform Bio-fabrication for Customised Anatomical Structures for Reconstructive Surgery. This project contributes towards the ARC priority goal on advanced materials and frontier technologies by developing an intelligent freeform biofabrication facility to produce accurate anatomical biocompatible replica structures and implants for reconstructive surgery. The products, produced from patient's CT or MRI scan data, will contribute to complex surgical procedure planning and patient ed ....Intelligent Freeform Bio-fabrication for Customised Anatomical Structures for Reconstructive Surgery. This project contributes towards the ARC priority goal on advanced materials and frontier technologies by developing an intelligent freeform biofabrication facility to produce accurate anatomical biocompatible replica structures and implants for reconstructive surgery. The products, produced from patient's CT or MRI scan data, will contribute to complex surgical procedure planning and patient education. The proposed facility will be based on multifunctional freeform fabrication process supported by intelligent software tools and database of biocompatible materials. The prospective outcomes are likely to have an excellent commercial and patenting potential that may help Australia become a leader in biomanufacturing technology.Read moreRead less