How the gut nervous system interacts with bacteria. This project aims to reveal how the enteric nervous system of the gastrointestinal (GI) tract interacts with the gut microbiota. Gut function has largely been studied without considering microbiota. The project will use genetically modified animal models, image analysis of gut motility and sequencing of gut microbes, and develop neurophysiological methods to understand gut function. Expected benefits include better understanding of mechanisms u ....How the gut nervous system interacts with bacteria. This project aims to reveal how the enteric nervous system of the gastrointestinal (GI) tract interacts with the gut microbiota. Gut function has largely been studied without considering microbiota. The project will use genetically modified animal models, image analysis of gut motility and sequencing of gut microbes, and develop neurophysiological methods to understand gut function. Expected benefits include better understanding of mechanisms underlying antibiotic resistance, risks associated with discretionary caesarean sections and the benefits of breastfeeding.Read moreRead less
Smart comparison and assessment of prediction models for better health using next generation data mining. Prediction models can be used to provide early warning of events, such as adverse medical outcomes. This project will develop principles for the smart management of large collections of prediction models using data mining, enabling more timely medical interventions for Australians to live healthier and longer.
Smart Algorithms Linking Medical Image Data and Measures of Dysfunction. Losing sight has a profound affect on a person's quality of life. Advances in devices that monitor vision have not been matched by advances in computer software that analyses data from those devices. This project will combine computer science, visual neuroscience and clinical expertise to devise algorithms and build software that will vastly improve clinician's abilities to diagnose and monitor vision loss. In turn, this wi ....Smart Algorithms Linking Medical Image Data and Measures of Dysfunction. Losing sight has a profound affect on a person's quality of life. Advances in devices that monitor vision have not been matched by advances in computer software that analyses data from those devices. This project will combine computer science, visual neuroscience and clinical expertise to devise algorithms and build software that will vastly improve clinician's abilities to diagnose and monitor vision loss. In turn, this will dramatically improve the chances of those with diseases such as glaucoma to preserve their sight into old age. Furthermore, outcomes from this project will inform the development bionic eye technologies, which will assist those with eye diseases such as retinis pigmantosa and age-related macular degeneration to see.Read moreRead less
Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be ca ....Erosion processes in soils across scales. This project aims to develop a monitoring tool for predicting the evolution of internal erosion in dams based on innovative electromagnetic observation methods. Internal erosion is an insidious process occurring in the obscurity of the soil’s pore system until its consequences become visible and threaten the stability of the dams. These water retaining structures are vital for the future water and energy supply for our society and their failure can be catastrophic. By establishing an improved understanding of internal erosion as a sequence of processes on various scales, from the onset of erosion until the failure of the structure, this project will place Australia at the forefront of dam safety assessment.Read moreRead less
Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importan ....Uncovering microRNA decay regulation in mammalian cells. MicroRNAs (miRNAs) constitute a novel mechanism used by cells to regulate gene expression, however, very little is known about the mechanisms affecting miRNA accumulation. Characterisation of the kinetics of miRNA turnover is of paramount importance to establish the reliability of miRNAs as novel biomarkers. This project aims to characterise miRNA stability in mammalian cells, investigate mechanisms of turnover and establish their importance on the regulatory function of miRNAs. Such information is critical in the future development of targeted therapeutics.Read moreRead less
Bottom-up multiscale modelling of expansive soils in natural environments . Expansive soils, highly sensitive to the environment, undergo dramatic strength and volume changes. This project aims to advance our understanding of expansive soils under different temperatures, hydraulic conditions, mechanical loads, and aqueous salinities. The project expects to use a combination of multidisciplinary knowledge, multiscale experiments and numerical simulations. The outcomes are a new multiscale model a ....Bottom-up multiscale modelling of expansive soils in natural environments . Expansive soils, highly sensitive to the environment, undergo dramatic strength and volume changes. This project aims to advance our understanding of expansive soils under different temperatures, hydraulic conditions, mechanical loads, and aqueous salinities. The project expects to use a combination of multidisciplinary knowledge, multiscale experiments and numerical simulations. The outcomes are a new multiscale model and advanced analysis/design tool for evaluating the performance of expansive soils under different conditions. The outcomes should provide the efficient way to mitigate the significant damage caused to infrastructure by expansive soils and facilitate the application of expansive soil products in waste disposal systems.Read moreRead less
Direct geothermal energy: harnessing an emerging technology. To mitigate the impacts of climate change, the demand for renewable energy technologies with low greenhouse gas (GHG) emissions is rapidly becoming a global priority. Direct geothermal systems use shallow ground as a heat source and sink for heating and cooling buildings, using ground heat exchangers (GHEs) and heat pumps. Substituting common heating and cooling systems with geothermal ones can reduce energy consumption by up to 75 per ....Direct geothermal energy: harnessing an emerging technology. To mitigate the impacts of climate change, the demand for renewable energy technologies with low greenhouse gas (GHG) emissions is rapidly becoming a global priority. Direct geothermal systems use shallow ground as a heat source and sink for heating and cooling buildings, using ground heat exchangers (GHEs) and heat pumps. Substituting common heating and cooling systems with geothermal ones can reduce energy consumption by up to 75 per cent and thus greenhouse gas emissions, since 91 per cent of electricity comes from fossil fuels in Australia. This project aims to develop new full scale physical and numerical models which will allow studying the effects of GHE configuration and intermittent use on efficiency and which will lead towards improving the poor and scarce existing design techniques.Read moreRead less
Designing functional biomaterials with superior cellular interactions. This proposal aims to make a new class of biomaterials that direct important cellular functions such as adhesion, proliferation, and differentiation. This will be achieved by developing materials that leverage a previously unexplored mechanism that was recently identified in my lab: the co-engagement of integrin and syndecan-4 cell receptors. We will use these biomaterials to 1) fabricate 3D printed tissue engineering scaffo ....Designing functional biomaterials with superior cellular interactions. This proposal aims to make a new class of biomaterials that direct important cellular functions such as adhesion, proliferation, and differentiation. This will be achieved by developing materials that leverage a previously unexplored mechanism that was recently identified in my lab: the co-engagement of integrin and syndecan-4 cell receptors. We will use these biomaterials to 1) fabricate 3D printed tissue engineering scaffolds with a superior ability to promote the development of new tissue, and 2) create surfaces that will enable us to answer fundamental scientific questions regarding cell adhesion and cell/material interactions.Read moreRead less
Novel cement-graphene oxide composite: understanding its composite structure via nano-mechanics based modelling and experimental tests. A high performance cement composite will be developed to reduce the usage of cement, and steel reinforcement, thus decrease carbon dioxide emissions, reduce labour costs, and promote sustainability. Modern modelling techniques will advance the knowledge in cement and concrete field and maintain the leading position of Australia.
Anchoring the next generation of offshore floating infrastructure. This project aims to advance the fundamental scientific understanding of embedded anchor behaviour and to develop engineering solutions to secure the next generation of floating platforms, wind turbines and submerged tunnels. This is significant because limited understanding of anchors under long-term sustained and cyclic loading, and in how wave-chain-anchor systems behave, is hindering confident deployment in deep water and har ....Anchoring the next generation of offshore floating infrastructure. This project aims to advance the fundamental scientific understanding of embedded anchor behaviour and to develop engineering solutions to secure the next generation of floating platforms, wind turbines and submerged tunnels. This is significant because limited understanding of anchors under long-term sustained and cyclic loading, and in how wave-chain-anchor systems behave, is hindering confident deployment in deep water and harsh conditions. This project will address this challenge by combining precise observations from sophisticated physical and numerical experiments into an analysis framework that integrates system response. Outcomes will include numerical software, analytical tools and design charts for engineers to use in design.Read moreRead less