Improved cryopreservation protocols for long term storage of platelets. The aim of this project is to characterise human blood platelet deterioration during cold storage and cryopreservation, and accelerate the development of improved long-term storage options. The project expects to generate important new knowledge about how platelets deteriorate during storage, and how such deterioration can be minimized. The expected outcomes are improved methods for long term platelet storage. This should be ....Improved cryopreservation protocols for long term storage of platelets. The aim of this project is to characterise human blood platelet deterioration during cold storage and cryopreservation, and accelerate the development of improved long-term storage options. The project expects to generate important new knowledge about how platelets deteriorate during storage, and how such deterioration can be minimized. The expected outcomes are improved methods for long term platelet storage. This should benefit blood donation services and hospitals by improving platelet delivery to remote locations, reducing wasted blood and the number of donations required, leading to significant financial savings.Read moreRead less
Linking topology and rheology for designing supramolecular polymer networks. This project aims to develop a foundation for understanding how microscopic topology and intermolecular interactions control the flow behaviour of supramolecular polymer networks. Brownian dynamics algorithms will be developed to unravel the complex dynamics of the network and calibrated by comparison with carefully designed experiments. The expected outcome of the project is a quantitative framework for connecting the ....Linking topology and rheology for designing supramolecular polymer networks. This project aims to develop a foundation for understanding how microscopic topology and intermolecular interactions control the flow behaviour of supramolecular polymer networks. Brownian dynamics algorithms will be developed to unravel the complex dynamics of the network and calibrated by comparison with carefully designed experiments. The expected outcome of the project is a quantitative framework for connecting the molecular structure and energy landscape with resulting macroscopic properties. This project should yield significant benefit in the rational design of supramolecular systems in which the thermorheological properties can be tuned over a wide range of force/time scales with applications spanning from enhanced oil recovery to injectable hydrogels.Read moreRead less
Rational design of new synthetic antifreeze molecules for cryopreservation. This project aims to synthesise new carbohydrate-based surfactants optimised for use as cryoprotectants, and to accurately measure, model and optimise their performance. The project will use state-of-the-art experimental methods and advanced phase-field modelling techniques to optimise the cryoprotectants so that they reduce osmotic stress in cells and inhibit ice crystal growth during freezing and thawing. The expected ....Rational design of new synthetic antifreeze molecules for cryopreservation. This project aims to synthesise new carbohydrate-based surfactants optimised for use as cryoprotectants, and to accurately measure, model and optimise their performance. The project will use state-of-the-art experimental methods and advanced phase-field modelling techniques to optimise the cryoprotectants so that they reduce osmotic stress in cells and inhibit ice crystal growth during freezing and thawing. The expected outcomes will be novel cryoprotectants that are easy to synthesise, non-toxic and effective, opening up new possibilities for the cryopreservation of cells, organs and possibly even whole organisms. This will have broad impact in critical applications such as long-term blood storage, reproductive technology and stem cell therapy, as well as preservation of endangered species.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100192
Funder
Australian Research Council
Funding Amount
$458,318.00
Summary
Quantum sensing of magnetism in two dimensions. This project aims to use innovative quantum sensing technologies to investigate the novel emerging field of two-dimensional magnetism; imaging both static and dynamic forms of 2D magnetism. This project expects to generate new knowledge about magnetic van der Waals materials and their potential application to ultra-thin electronic and spintronic devices. Expected outcomes of this project are a deeper understanding of the formation and modulation of ....Quantum sensing of magnetism in two dimensions. This project aims to use innovative quantum sensing technologies to investigate the novel emerging field of two-dimensional magnetism; imaging both static and dynamic forms of 2D magnetism. This project expects to generate new knowledge about magnetic van der Waals materials and their potential application to ultra-thin electronic and spintronic devices. Expected outcomes of this project are a deeper understanding of the formation and modulation of magnetic order in 2D, new fabrication methods for deliberate domain wall formation, production of near-zero energy gap spin-waves, and new encapsulation methods for ultra-stable 2D materials. This should provide significant benefits towards fundamental physics and future device engineering. Read moreRead less
Precise atomic-scale structure determination in thick nanostructures. This project aims to tackle a great challenge of atomic-scale characterisation: quantitative structure determination. Powerful new electron microscopes offer a window into the atomic world, but complex electron multiple scattering has limited reliable structure determination to ultrathin materials. This project expects to overcome this barrier. Anticipated outcomes include methods that use the latest detector technology to det ....Precise atomic-scale structure determination in thick nanostructures. This project aims to tackle a great challenge of atomic-scale characterisation: quantitative structure determination. Powerful new electron microscopes offer a window into the atomic world, but complex electron multiple scattering has limited reliable structure determination to ultrathin materials. This project expects to overcome this barrier. Anticipated outcomes include methods that use the latest detector technology to determine structure and interatomic bonding in much thicker nanostructures than hitherto possible. This should benefit academic and industrial researchers by giving them new tools to understand and design high-performance materials for applications ranging from catalysis to energy storage to next-generation electronics.Read moreRead less
Improving the stability of biomolecules using ionic liquids. This project aims to address critical issues in studying proteins outside their native environments by developing new solvents that will increase their stability and solubility. The project expects to create new knowledge in our understanding of solvent chemical properties through a novel approach using high throughput robotics, synchrotron analysis of protein structures and Molecular Dynamics simulations. The expected outcome is a set ....Improving the stability of biomolecules using ionic liquids. This project aims to address critical issues in studying proteins outside their native environments by developing new solvents that will increase their stability and solubility. The project expects to create new knowledge in our understanding of solvent chemical properties through a novel approach using high throughput robotics, synchrotron analysis of protein structures and Molecular Dynamics simulations. The expected outcome is a set of design rules for creating new solvents. This should benefit many research and industrial applications, including determining protein structure for the development of new drugs and biocatalysts, and cryopreservation of protein-based pharmaceuticals.Read moreRead less
Unlocking the potential of magnetic 2D materials with quantum microscopy. This project aims to create a universal, high-throughput platform to characterise magnetic 2D materials, by exploiting recently developed quantum diamond microscopy. It will enable the measurement of hitherto inaccessible magnetic properties of individual 2D microsheets, the imaging of device-relevant phenomena such as domain wall dynamics and skyrmionics, and the systematic screening of newly synthesised materials. Antici ....Unlocking the potential of magnetic 2D materials with quantum microscopy. This project aims to create a universal, high-throughput platform to characterise magnetic 2D materials, by exploiting recently developed quantum diamond microscopy. It will enable the measurement of hitherto inaccessible magnetic properties of individual 2D microsheets, the imaging of device-relevant phenomena such as domain wall dynamics and skyrmionics, and the systematic screening of newly synthesised materials. Anticipated outcomes include crucial new insights into 2D magnetism and the discovery of magnetic 2D materials compatible with real-world conditions. This should accelerate the development of future energy-efficient and flexible electronics and memory technologies, where magnetic 2D materials are expected to play a key role.
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Braiding Dynamics of Majorana Modes. The project aims to investigate Majorana modes, exotic quantum particles which can be found in the new material class of Topological Superconductivity. In particular, they can be utilised to construct fault-tolerant quantum bits. Quantum logic gates are enabled by moving these Majorana modes around each other, i.e., by braiding them, leading to an error-free quantum performance. This project will deliver cutting-edge simulations to analyse the braiding proces ....Braiding Dynamics of Majorana Modes. The project aims to investigate Majorana modes, exotic quantum particles which can be found in the new material class of Topological Superconductivity. In particular, they can be utilised to construct fault-tolerant quantum bits. Quantum logic gates are enabled by moving these Majorana modes around each other, i.e., by braiding them, leading to an error-free quantum performance. This project will deliver cutting-edge simulations to analyse the braiding process in condensed matter systems and benchmark how these fault-tolerant quantum bits operate under real-world conditions. By providing the theory for advanced structures and devices, this project will inform experiments and pave the way for future technology based on topological phenomena.Read moreRead less
Quantum Design of Majorana Modes in Magnet-Superconductor Hybrid Systems. This project will identify magnet-superconductor hybrid structures which feature topological superconductivity, a new material class which promises to revolutionise future technology. By performing cutting-edge transport calculations, this project will also predict signatures of topological superconductors for ongoing and future experiments. Expected outcomes of this project include identification of suitable candidate mat ....Quantum Design of Majorana Modes in Magnet-Superconductor Hybrid Systems. This project will identify magnet-superconductor hybrid structures which feature topological superconductivity, a new material class which promises to revolutionise future technology. By performing cutting-edge transport calculations, this project will also predict signatures of topological superconductors for ongoing and future experiments. Expected outcomes of this project include identification of suitable candidate materials and protocols for the quantum design of prototype devices. By providing the theory of advanced structures and devices, this project will inform experiments and pave the way for future technology based on topological phenomena.Read moreRead less