Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100081
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The pr ....Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The proposed facility will provide significant benefits to Australian researchers in drug design and delivery, nano-material design and characterisation at nano scale for advanced materials, and promotion of renewable energy. This represents a great opportunity to make discoveries and breakthroughs in frontier science and technology in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238898
Funder
Australian Research Council
Funding Amount
$352,000.00
Summary
Novel Optical Microprobes - fluorescence excitation, lifetime and surface enhanced Raman spectroscopies. State-of-the-art technologies in microscopy will be combined with the versatility and diagnostic power of spectroscopy for the analysis and identification of materials by methods sensitive to chemical structure as well as spatial inhomogeneity. The proposed systems will operate within an existing multi-user optical characterisation facility at Macquarie University thus supporting the research ....Novel Optical Microprobes - fluorescence excitation, lifetime and surface enhanced Raman spectroscopies. State-of-the-art technologies in microscopy will be combined with the versatility and diagnostic power of spectroscopy for the analysis and identification of materials by methods sensitive to chemical structure as well as spatial inhomogeneity. The proposed systems will operate within an existing multi-user optical characterisation facility at Macquarie University thus supporting the research of an established and expanding network of researchers in the Sydney area and in Melbourne. The suite of instruments will provide new and exciting avenues for interdisciplinary research between the physical and biological sciencesRead moreRead less
Superfluid helium nanodroplet spectroscopy. Molecules trapped in a helium nanodroplet find themselves in an ultracold liquid environment from which they cannot escape. As such, the molecules are forced to interact and this is studied at a resolution that is unrivaled in condensed phase spectroscopy. This technique will be used to create new materials and study the dynamics behind a large range of chemical processes. The results are expected to lead to a greater understanding of condensed phase c ....Superfluid helium nanodroplet spectroscopy. Molecules trapped in a helium nanodroplet find themselves in an ultracold liquid environment from which they cannot escape. As such, the molecules are forced to interact and this is studied at a resolution that is unrivaled in condensed phase spectroscopy. This technique will be used to create new materials and study the dynamics behind a large range of chemical processes. The results are expected to lead to a greater understanding of condensed phase chemistry and chemical reactions in general.Read moreRead less
The role of redox balance and reactive oxygen species in beer stability using an integrated transcriptomic and metabolomic analysis. A better understanding of yeast redox balance will enable it to be used to predict fermentation outcomes and to link raw materials and processes to the quality of the final product. These data will produce economies in the brewing industry by the introduction of quality control regimes for raw materials and can be extrapolated to the wine industry. This will prov ....The role of redox balance and reactive oxygen species in beer stability using an integrated transcriptomic and metabolomic analysis. A better understanding of yeast redox balance will enable it to be used to predict fermentation outcomes and to link raw materials and processes to the quality of the final product. These data will produce economies in the brewing industry by the introduction of quality control regimes for raw materials and can be extrapolated to the wine industry. This will provide real economic advantage to Carlton and United Breweries which is an Australian company that has an international profile within a highly competitive industry.Read moreRead less
Application of functional genomics to study early fermentation parameters and flavour development in industrial fermentations. The aim of this research is to use genome-wide analyses to identify yeast genes involved in flavour compound production in order to manipulate the flavour profiles of industrial fermentations. This will identify those metabolic pathways and cellular processes that are important in the maintenance of flavour production during fermentation and give extensive insight into t ....Application of functional genomics to study early fermentation parameters and flavour development in industrial fermentations. The aim of this research is to use genome-wide analyses to identify yeast genes involved in flavour compound production in order to manipulate the flavour profiles of industrial fermentations. This will identify those metabolic pathways and cellular processes that are important in the maintenance of flavour production during fermentation and give extensive insight into the way metabolism changes during the fermentation process. Flavour is a major component of the product of fermented beverages and its development and maintenance in the finished product is of primary concern to the brewing and wine industries. This research will lead to a more competitive Australian-owned company with a major stake in the beer and wine industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347746
Funder
Australian Research Council
Funding Amount
$199,000.00
Summary
Circular-dichroism stopped-flow spectrometer for rapid molecular interactions and membrane transport. A stopped-flow spectroscope is requested that can capture the rapid kinetics of changes in conformation of biopolymers, macromolecules and chiral catalysts as they interact with other molecules. This includes measurement of rapid transport of solutes through membrane proteins in lipid membranes. The versatile instrument can also determine circular dichroism spectra of peptides, proteins, tannins ....Circular-dichroism stopped-flow spectrometer for rapid molecular interactions and membrane transport. A stopped-flow spectroscope is requested that can capture the rapid kinetics of changes in conformation of biopolymers, macromolecules and chiral catalysts as they interact with other molecules. This includes measurement of rapid transport of solutes through membrane proteins in lipid membranes. The versatile instrument can also determine circular dichroism spectra of peptides, proteins, tannins, pigment complexes and chiral catalysts that is required within several existing collaborations to understand the tertiary structures, stability and interactions between the complex molecules. The instrument will significantly strengthen research on macromolecules and polymers that have applications in the wine industry, nanotechnology, and biotechnology.Read moreRead less
Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce ....Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce knowledge of broad relevance to modern life sciences and its applications in medicine and biotechnology. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
Application of genome-wide transcriptional analysis to identifying genetic markers for industrial fermentation processes. This project aims to identify yeast genes involved in the response of commercial strains to stress, to determine their role in fermentation and the genetic pathways through which they operate. The ultimate goals are to determine the impact on fermentation activity of stress, and to develop predictive methods for assessing such conditions. This has significance since stress ....Application of genome-wide transcriptional analysis to identifying genetic markers for industrial fermentation processes. This project aims to identify yeast genes involved in the response of commercial strains to stress, to determine their role in fermentation and the genetic pathways through which they operate. The ultimate goals are to determine the impact on fermentation activity of stress, and to develop predictive methods for assessing such conditions. This has significance since stress during fermentation represents a significant commercial loss. The outcomes of this work will be a better understanding of how yeast responds to stress, and the identification of genes that can be used by the commercial partner to monitor and ensure fermentation efficiency.Read moreRead less
Determining the sequence of events during eukaryotic translation initiation. Multiple benefits will arise from a more complete understanding of translation initiation. It is a frequent target for mechanisms that control gene expression and its dys-regulation is associated with human disease. For example, this is evident in cancer biology, since altered translation is a frequent cause of tumorigenesis. Translation is of universal importance for cellular function and knowledge of how it works is c ....Determining the sequence of events during eukaryotic translation initiation. Multiple benefits will arise from a more complete understanding of translation initiation. It is a frequent target for mechanisms that control gene expression and its dys-regulation is associated with human disease. For example, this is evident in cancer biology, since altered translation is a frequent cause of tumorigenesis. Translation is of universal importance for cellular function and knowledge of how it works is central to modern life sciences and its application to medical and biotechnological problems. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less