Discovery Early Career Researcher Award - Grant ID: DE210100291
Funder
Australian Research Council
Funding Amount
$414,000.00
Summary
Conferring life-like functions to protocells. For life to have arisen, simple self-assembled chemicals must have performed key life-like functions. This project aims to generate new knowledge in the fields of soft condensed matter physics and astrobiology by understanding how primitive life could have obtained nutrients and completed “cell” division without proteins. This ambitious goal is expected to not only contribute towards understanding the origins of life, one of the grand challenges in s ....Conferring life-like functions to protocells. For life to have arisen, simple self-assembled chemicals must have performed key life-like functions. This project aims to generate new knowledge in the fields of soft condensed matter physics and astrobiology by understanding how primitive life could have obtained nutrients and completed “cell” division without proteins. This ambitious goal is expected to not only contribute towards understanding the origins of life, one of the grand challenges in science, but also to elucidate principles in membrane biophysics and self-assembly. The fundamental scientific findings will be applied to making responsive capsules that can confer advanced functionalities to soft materials. Several international collaborations are anticipated.Read moreRead less
A scalable, synthetic retina: signal processing in droplet systems with DNA. This project aims to design DNA-based nanotechnology for processing optical signals in synthetic biological systems. The intended outcome of this project is to develop a system for signal transduction in artificial bilayers using new DNA nanostructures. The anticipated goal of the project is to deliver: 1) light-based control of membrane protein insertion into artificial bilayers; 2) novel DNA-based pores that can trans ....A scalable, synthetic retina: signal processing in droplet systems with DNA. This project aims to design DNA-based nanotechnology for processing optical signals in synthetic biological systems. The intended outcome of this project is to develop a system for signal transduction in artificial bilayers using new DNA nanostructures. The anticipated goal of the project is to deliver: 1) light-based control of membrane protein insertion into artificial bilayers; 2) novel DNA-based pores that can transduce signals across membranes; 3) signal processing using multi-compartment biological components composed. Together, this technology allows us to use light and external signals to control biochemical pathways in synthetic systems.Read moreRead less
The geometry of genome access: lessons from HIV. Access to the cell’s nucleus, and hence its genome, is of deep scientific and commercial significance. It is controlled by a phase-separated diffusion barrier within the nuclear pore complex. Recent evidence, however, has shown that HIV can cross this barrier with its protective capsid intact, despite it being over one thousand times larger than the limit for passive transport. Combining concepts from soft-matter physics with recombinant assays, t ....The geometry of genome access: lessons from HIV. Access to the cell’s nucleus, and hence its genome, is of deep scientific and commercial significance. It is controlled by a phase-separated diffusion barrier within the nuclear pore complex. Recent evidence, however, has shown that HIV can cross this barrier with its protective capsid intact, despite it being over one thousand times larger than the limit for passive transport. Combining concepts from soft-matter physics with recombinant assays, this project aims to uncover the link between the unique geometry of HIV capsids and their ability to subvert the nucleus’ defenses. The expected outcome is a step-change in the understanding of nuclear access control, with downstream benefits to virology, bio-engineering and bio-technology.Read moreRead less
Rational design of new synthetic antifreeze molecules for cryopreservation. This project aims to synthesise new carbohydrate-based surfactants optimised for use as cryoprotectants, and to accurately measure, model and optimise their performance. The project will use state-of-the-art experimental methods and advanced phase-field modelling techniques to optimise the cryoprotectants so that they reduce osmotic stress in cells and inhibit ice crystal growth during freezing and thawing. The expected ....Rational design of new synthetic antifreeze molecules for cryopreservation. This project aims to synthesise new carbohydrate-based surfactants optimised for use as cryoprotectants, and to accurately measure, model and optimise their performance. The project will use state-of-the-art experimental methods and advanced phase-field modelling techniques to optimise the cryoprotectants so that they reduce osmotic stress in cells and inhibit ice crystal growth during freezing and thawing. The expected outcomes will be novel cryoprotectants that are easy to synthesise, non-toxic and effective, opening up new possibilities for the cryopreservation of cells, organs and possibly even whole organisms. This will have broad impact in critical applications such as long-term blood storage, reproductive technology and stem cell therapy, as well as preservation of endangered species.Read moreRead less
Hot Topic: Quantum Design of Phononic Heat Filters. Heat management is critical to many technologies for sustainable energy, electronics, protective equipment and energy-efficient buildings. The phonon is the quantum particle representing a travelling vibration and is responsible for the transmission of heat in solids. This project will study the new mechanisms for phonon transport in solids modified with embedded nanoparticles, which operate as phononic filters. Neutron spectroscopy provides a ....Hot Topic: Quantum Design of Phononic Heat Filters. Heat management is critical to many technologies for sustainable energy, electronics, protective equipment and energy-efficient buildings. The phonon is the quantum particle representing a travelling vibration and is responsible for the transmission of heat in solids. This project will study the new mechanisms for phonon transport in solids modified with embedded nanoparticles, which operate as phononic filters. Neutron spectroscopy provides a tool to measure the phonon density of states which is critical for developing a mathematical model of thermal boundary resistance. This is expected to identify mechanisms for ultra-low thermal conductivity leading to potential applications in thermoelectric generators and heat-resistant materials.Read moreRead less
Magnonics with skyrmions. Skyrmions – nanoscale topologically protected spin textures, are considered as ideal candidates for encoding and transmitting bits of information. This burgeoning research field, however, suffers from the same limitations of all spintronic concepts – the high currents needed to move skyrmions. Magnonics is yet another emerging approach, which main aim is to investigate the behaviour of spin waves in magnetic nanostructures. In essence, spin waves are a propagating re-or ....Magnonics with skyrmions. Skyrmions – nanoscale topologically protected spin textures, are considered as ideal candidates for encoding and transmitting bits of information. This burgeoning research field, however, suffers from the same limitations of all spintronic concepts – the high currents needed to move skyrmions. Magnonics is yet another emerging approach, which main aim is to investigate the behaviour of spin waves in magnetic nanostructures. In essence, spin waves are a propagating re-ordering of the magnetisation and therefore use the least amount of power, making them perfect for driving skyrmions. This project fuses skyrmions with magnonics. The central goal is the formulation of model for the magnon assisted manipulation of skyrmions and their lattices.Read moreRead less