Identifying risk markers for depression: A cognitive neuroscience approach. This project will establish objective markers for detecting early signs of depression. These markers are crucial in enabling early intervention to limit the course of depression. They will also benefit the development of prevention strategies, since they provide a means to identify high risk individuals. Currently there exists no simple and objective test or set of markers that can detect the early signs of depression. T ....Identifying risk markers for depression: A cognitive neuroscience approach. This project will establish objective markers for detecting early signs of depression. These markers are crucial in enabling early intervention to limit the course of depression. They will also benefit the development of prevention strategies, since they provide a means to identify high risk individuals. Currently there exists no simple and objective test or set of markers that can detect the early signs of depression. The available tests provide information relevant to the later-stage of clinical depression only. In this regard, non-invasive and objective markers are urgently required to limit the burden of depression. In Australia, $3.3 billion in productivity and 12 million working days are lost each year as a result of depression.Read moreRead less
Gene-brain pathways in emotional brain stability and instability. Emotional instability is a defining trait of major mental illnesses. The ability to identify individuals susceptible to emotional instability will be important in limiting the burden of disease from these illnesses. Mental conditions cost the Australian economy approximately $14.9 bill p/a, and depression will be the second leading contributor to burden of disease by 2020. The project will provide the first evidence for the combin ....Gene-brain pathways in emotional brain stability and instability. Emotional instability is a defining trait of major mental illnesses. The ability to identify individuals susceptible to emotional instability will be important in limiting the burden of disease from these illnesses. Mental conditions cost the Australian economy approximately $14.9 bill p/a, and depression will be the second leading contributor to burden of disease by 2020. The project will provide the first evidence for the combination of gene-brain-behaviour markers which best capture emotional instability versus resilience. This evidence base will be crucial to developing new tools and strategies for early intervention, and ultimately prevention, for these conditions of mental health.Read moreRead less
The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two insta ....The associative mechanisms underlying extinction and latent inhibition. Formal models that explain how animals learn associations between stimuli have enjoyed considerable success, and have even been identified with neurophysiological mechanisms. Theoretical analysis of the opposite, though equally important, form of learning - that two stimuli are not associated - lags far behind, due to fundamental methodological confounds that plague research on this topic. This project investigates two instances of this learning: extinction and latent inhibition. Using a new procedure that avoids earlier confounds, we will describe and compare the processes underlying extinction and latent inhibition. This research will represent a major breakthrough in our understanding about fundamental processes in learning.Read moreRead less
A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of ....A philosophical and empirical approach to the nature of perception and belief. This project offers substantial benefits - intellectual, practical, and ultimately economic - to the nation. On the intellectual side, the project will contribute to research output and will further enhance the national research strength in the study of delusions, rationality, and agency, within both philosophy of mind and inter-disciplinary cognitive science. On the practical side, the project offers the prospect of considerable benefits for the community as improved theories of the nature and causes of delusions generate strategies for earlier detection or even prevention of the development of delusions, new methods of therapy for patients, and better understanding for families.Read moreRead less
Acquiring Social Fears in Infancy: Underlying Mechanisms and Implications for Behavioural Intervention. Social fears are wide-spread in the community and crippling for those affected. This study aims to (i) isolate parental behaviours and practices that result in elevated and persistent infant fear within social interactions, and (ii) establish the psychological mechanisms (e.g., observational learning) and temperamental features that underpin the transmission of social fears from mother to infa ....Acquiring Social Fears in Infancy: Underlying Mechanisms and Implications for Behavioural Intervention. Social fears are wide-spread in the community and crippling for those affected. This study aims to (i) isolate parental behaviours and practices that result in elevated and persistent infant fear within social interactions, and (ii) establish the psychological mechanisms (e.g., observational learning) and temperamental features that underpin the transmission of social fears from mother to infant. By elucidating the processes involved in the transmission of social fears, this investigation will enrich theories of emotional development in infancy, contribute to our understanding of serious conditions such as childhood shyness and Social Phobia, and provide an empirical basis for the development of effective methods of early intervention.Read moreRead less
Hypnosis and Emotional Numbing. Emotional numbing, or lack of emotional response, is a core problem in many clinical disorders. This project represents an innovative approach by using hypnosis to model emotional numbing in the laboratory and to investigate the mechanisms and effects of emotional numbing under experimental conditions. These studies will shed new light on the major factors that contribute to this form of emotional disorder, will lead to a new model of emotional numbing, and will ....Hypnosis and Emotional Numbing. Emotional numbing, or lack of emotional response, is a core problem in many clinical disorders. This project represents an innovative approach by using hypnosis to model emotional numbing in the laboratory and to investigate the mechanisms and effects of emotional numbing under experimental conditions. These studies will shed new light on the major factors that contribute to this form of emotional disorder, will lead to a new model of emotional numbing, and will have significant implications for our understanding and management of disordered emotional states.Read moreRead less
Cognitive neuropsychiatry: understanding delusional belief and delusional hallucination from a cognitive neuropsychological perspective. Cognitive neuropsychiatry aims to explain psychiatric symptoms in terms of abnormalities in the functioning of the human mind. This project applies a two-factor model of this type to better understand delusion and hallucination. In this model, a distinction is drawn between factors which explain the initial generation of an abnormal thought and factors which ex ....Cognitive neuropsychiatry: understanding delusional belief and delusional hallucination from a cognitive neuropsychological perspective. Cognitive neuropsychiatry aims to explain psychiatric symptoms in terms of abnormalities in the functioning of the human mind. This project applies a two-factor model of this type to better understand delusion and hallucination. In this model, a distinction is drawn between factors which explain the initial generation of an abnormal thought and factors which explain the uncritical acceptance, rather than rejection, of the abnormal thought. The generality of this model will be evaluated by investigating delusions in a range of clinical contexts. Findings may contribute to the design of more effective cognitive-behaviour therapies for treating psychosis in different clinical conditions.Read moreRead less
Augmentation of fear extinction in anxious children through the use of D-Cycloserine. Anxiety disorders affect around a tenth of the population, including children, and produce tremendous personal and social costs. Improving our treatments for anxious children can help to prevent a lifetime of limitations and difficulties. This study will examine whether giving children a small dose of a simple antibiotic can increase the extent to which they lose their fears of specific cues when exposed to tho ....Augmentation of fear extinction in anxious children through the use of D-Cycloserine. Anxiety disorders affect around a tenth of the population, including children, and produce tremendous personal and social costs. Improving our treatments for anxious children can help to prevent a lifetime of limitations and difficulties. This study will examine whether giving children a small dose of a simple antibiotic can increase the extent to which they lose their fears of specific cues when exposed to those cues. These results have the potential to revolutionise our understanding and treatment of child anxiety.Read moreRead less
An Investigation of Intersubjectivity: Music Therapy and Hospitalised Infants. A contingent relationship is vital for normal infant development. The Neonatal Intensive Care Unit, which supplies life-saving modern medical technology to very sick infants, is also an environment where contingency is rarely available to the infant . In this environment, a Music Therapist ?improvising? with the infant, can re-introduce contingency to the infant, and encourage infant self-regulation. This project inv ....An Investigation of Intersubjectivity: Music Therapy and Hospitalised Infants. A contingent relationship is vital for normal infant development. The Neonatal Intensive Care Unit, which supplies life-saving modern medical technology to very sick infants, is also an environment where contingency is rarely available to the infant . In this environment, a Music Therapist ?improvising? with the infant, can re-introduce contingency to the infant, and encourage infant self-regulation. This project investigates the efficacy of a Music Therapy intervention in improving infant health, and micro-analyses the interaction between infant and therapist in order to further understand the nature of the Communicative Musicality of the interaction.Read moreRead less
Towards a continuum model of orienting and defensive responses. Orienting (OR) and Defensive Responses (DR) underlie important survival functions of attending to unexpected stimuli and avoiding harm.We will establish the first integrative profile of human OR/DR function, using simultaneous recording of brain activity and 'body' responsivity. Given sex and age variation in OR/DRs, both males and females spanning six decades will be studied. OR/DR abnormalities are associated with major disorders ....Towards a continuum model of orienting and defensive responses. Orienting (OR) and Defensive Responses (DR) underlie important survival functions of attending to unexpected stimuli and avoiding harm.We will establish the first integrative profile of human OR/DR function, using simultaneous recording of brain activity and 'body' responsivity. Given sex and age variation in OR/DRs, both males and females spanning six decades will be studied. OR/DR abnormalities are associated with major disorders of attention and stress, which also vary with sex and age. We will examine relationships between OR/DR function and proneness to these disorders in healthy individuals. The results will provide a framework for developing prevention and intervention strategies.Read moreRead less