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  • Funded Activity

    A Comprehensive Regulatory Strategy For Obesity Prevention In Australia

    Funder
    National Health and Medical Research Council
    Funding Amount
    $810,696.00
    Summary
    This research aims to develop regulatory approaches to obesity prevention and the reduction of socio-economic inequalities in obesity prevalence. Laws related to the provision, marketing, and labelling of food, urban planning, transportation, taxes and subsidies and so on will be comprehensively analysed and prioritised, and options proposed for legislative reform. The evidence-base and the implementation pathways will be developed contemporaneously and will be widely promoted to governments. A .... This research aims to develop regulatory approaches to obesity prevention and the reduction of socio-economic inequalities in obesity prevalence. Laws related to the provision, marketing, and labelling of food, urban planning, transportation, taxes and subsidies and so on will be comprehensively analysed and prioritised, and options proposed for legislative reform. The evidence-base and the implementation pathways will be developed contemporaneously and will be widely promoted to governments. A significant portion of time will be devoted to working closely with those within the bureaucracy who administer the law and legislators who together make the relevant policy decisions so that they may gain an understanding of the rationale behind each recommendation.
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    A Prospective Study To Examine The Effectiveness And Safety Of Antivirals Against Pandemic Influenza

    Funder
    National Health and Medical Research Council
    Funding Amount
    $142,394.00
    Summary
    Pandemic influenza could cause significant mortality in populations of Australia and the south-east Asian region. Currently, avian influenza A (H5N1) is a concern to public health agencies because of its extreme pathogenicity. At present this strain is not transmitted readily between humans. A number of drugs are available to treat influenza infection in humans and research has shown these to be effective in preventing significant mortality in the setting of seasonal influenza epidemics (specifi .... Pandemic influenza could cause significant mortality in populations of Australia and the south-east Asian region. Currently, avian influenza A (H5N1) is a concern to public health agencies because of its extreme pathogenicity. At present this strain is not transmitted readily between humans. A number of drugs are available to treat influenza infection in humans and research has shown these to be effective in preventing significant mortality in the setting of seasonal influenza epidemics (specifically the influenza neuraminidase inhibitors _NIs). As a consequence public health agencies around the world have been stockpiling these drugs and developing sophisticated plans for their use if an influenza pandemic was announced. However, there are no data indicating that the neuraminidase inhibitors (NIs) are safe and effective when used to manage pandemic influenza. Neither are there any data to support the use of these drugs on a population basis. Genetic resistance to NIS has been described but it is not clear if this has any relevance to public health. Our research will clarify this issue. This project will develop a number of clinical trials that could be implemented rapidly should pandemic influenza ever be announced by health authorities in Australia-Singapore or Hong Kong. Patients with suspected influenza infection will be asked to provide informed consent prior to commencing NI therapy. Clinical information will then be collected for a period of approximately one month along with some blood samples and swabs from the throat and nasal passages. Data will be analysed as quickly as possible to help inform the continued use of NI therapy as a cornerstone of the public health agency response to pandemic influenza. In addition, the study team will prepare clinical trials to be conducted in essential workers who are likely to receive long-term NI preventive treatment as well as the immediate contacts of people with presumed influenza infection who are likely to receive short-term prophylaxis with NIs.
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    The Development Of A Model Of Care For Haematology And Palliative Care

    Funder
    National Health and Medical Research Council
    Funding Amount
    $149,044.00
    Summary
    The aim of the multi-site partnership is to build on foundational work initiated by NH and MRC to establish a model for end-of-life care in adult Haematology and palliative care. Preliminary work indicates this diagnostic category does NOT presently receive palliative care. Consumer research indicates that end-of-life care in haematology is associated with the distress of escalating technology, post-traumatic stress and spiritual pain. This study seeks to address this situation by building on th .... The aim of the multi-site partnership is to build on foundational work initiated by NH and MRC to establish a model for end-of-life care in adult Haematology and palliative care. Preliminary work indicates this diagnostic category does NOT presently receive palliative care. Consumer research indicates that end-of-life care in haematology is associated with the distress of escalating technology, post-traumatic stress and spiritual pain. This study seeks to address this situation by building on the prior consumer researcher to develop a model of care through a multi-disciplinary consultation with haematology professionals and consumers.
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    Renal Dialysis Abatement: Decision-making & Social Impact Of The Transition To Terminal Care

    Funder
    National Health and Medical Research Council
    Funding Amount
    $100,000.00
    Summary
    A study of the impact on patients and their families of the decision to stop kidney machine dialysis, and the transition to terminal care, either in an in-patient hospice-palliative care unit or domicillary service. The study will employ a combination of quantitative demographic and qualitative social science methodologies. There will be a special focus on the decision-making process, given that a dialysis cessation decision will usually lead to death within a few weeks.
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    Potential Avian Influenza-induced Pandemic: Minimising Public Panic

    Funder
    National Health and Medical Research Council
    Funding Amount
    $249,854.00
    Summary
    Communication appearing in the Australian media regarding a potential bird flu epidemic can serve to accurately and effectively inform the public OR misinform and contribute to panic and undesirable behavioural responses. The Australian Government has time to develop communication strategies and specific messages that can effectively convey desired information at different stages of the anticipated pandemic. This research team proposes to develop communication strategies (including specific mess .... Communication appearing in the Australian media regarding a potential bird flu epidemic can serve to accurately and effectively inform the public OR misinform and contribute to panic and undesirable behavioural responses. The Australian Government has time to develop communication strategies and specific messages that can effectively convey desired information at different stages of the anticipated pandemic. This research team proposes to develop communication strategies (including specific messages, media vehicles, spokespeople, images etc for the different target audiences) that government, medical authorities, NGOs and other relevant organisations can use to increase the public's understanding of the risk. Such strategies will ensure that we can minimise fear, refute misinformation the public may encounter from individuals (e.g., co-workers) or media sources, and enhance the likelihood of the public taking the recommended preventive and remedial actions should an Avian Influenza pandemic occur. Additionally, the research team will then utilise these communication strategies to develop evidence-based guidelines for communication strategies to be used in cases of similar serious health threats in Australia. Based at the University of Wollongong, the project team is a sophisticated and synergistically qualified team of experts. The team includes: a main media health promotions expert (Associate Professor Sandra Jones); two marketing communications experts, one of whom has an academic focus and the other a practitioner focus (Professor John Rossiter and Dr Max Sutherland respectively); a public health and medical expert in health behaviour change (Professor Don Iverson); a senior public health campaigns expert (Professor Chris Puplick), and an expert in communicable diseases and infection control education and programs (Professor Julian Gold).
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    Production Of Nasal Filters: Enhanced Prophylactic Protection From Aerosol Exposure

    Funder
    National Health and Medical Research Council
    Funding Amount
    $147,000.00
    Summary
    Influenza is a highly contagious disease that is transmitted via infective secretions containing the virus. An infected person produces tiny droplets of these secretions when coughing, sneezing, and talking, and the droplets are disseminated into the air where they are subsequently inhaled by others. A common way of preventing such transmission is to wear a mask to prevent droplet inhalation. While such masks may greatly reduce exposure, they do not eliminate it, as some viruses can pass around .... Influenza is a highly contagious disease that is transmitted via infective secretions containing the virus. An infected person produces tiny droplets of these secretions when coughing, sneezing, and talking, and the droplets are disseminated into the air where they are subsequently inhaled by others. A common way of preventing such transmission is to wear a mask to prevent droplet inhalation. While such masks may greatly reduce exposure, they do not eliminate it, as some viruses can pass around the edges of masks, particularly if it fits poorly, and also a small percentage can pass through the filter material. While influenza is usually not a major health problem in the general community, the emergence of a more hazardous strain will place an additional burden on health care and other facilities, and requires the development and optimization of measures to minimize virus spread and protect those who are exposed. The aim of this project is to build small filters that can be worn in the nose to provide additional filtration of inhaled air. These filters would be worn in combination with a mask in high exposure circumstances, such as by health care workers when treating infected patients or could be used when a mask was not normally worn to provide effective and discreet protection, such as in crowded public places. Developing such filters builds on our experience of making small samplers worn in the nose to measure allergen exposure. This experience is combined with advanced filter materials developed by leading US researchers that permit the efficient filtration of particles as small as viruses. This project will be conducted in collaboration with a leading Australian design group, and we will design and evaluate such filters for their ability to capture virus and thus protect the wearer. The filters should provide an intuitive, effective and inexpensive method to be used in combination with other hygiene measures to increase personal protection from acquiring highly transmissible respiratory diseases, particularly influenza. We expect to have prototypes of the filters available in 6 months so that production can commence.
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    Improving Identification And Treatment Of Early-onset Behaviour Disorders In Children

    Funder
    National Health and Medical Research Council
    Funding Amount
    $498,869.00
    Summary
    Most mental health problems begin in childhood and adolescence. Of these, oppositional-defiant and conduct problems in childhood are the most common precursor of all types of adult mental health problems. These children are the most common referral to child mental health clinics but little is known about which of these children will go in which direction i.e., good health, chronic antisocial behaviour, depression and anxiety, substance abuse, the psychoses. Progress in more accurately defining s .... Most mental health problems begin in childhood and adolescence. Of these, oppositional-defiant and conduct problems in childhood are the most common precursor of all types of adult mental health problems. These children are the most common referral to child mental health clinics but little is known about which of these children will go in which direction i.e., good health, chronic antisocial behaviour, depression and anxiety, substance abuse, the psychoses. Progress in more accurately defining subgroups of these children would have huge implications for early intervention for mental health problems in our community. This project proposes the first large scale analysis of genetic distributions through to behavioural and treatment factors that characterise and differentiate a large representative sample of children with conduct problems. The project will test a model of child psychopathology that links genotype, via environmental risk and emotion processing problems, to an improved diagnostic-phenotypic model for treatment of the major childhood disorder. Clinical research activities will be structured into three intersecting arms: first, identifying the genetic and behavioural subtypes of early-onset conduct problems; second, innovative treatments for these children, and third, the dissemination of findings to these children and their families via the health care system. The research will build new collaborations between established and internationally recognised clinical research teams in childhood mental health, biological psychiatry, genetics and the Child and Adolescent Mental Health Statewide Network (CAMHSNET). CAMHSNET have specific responsibilities to NSW Health for expert advice and input on the development of child mental health services directions, dissemination, training, and effectiveness research.
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    Funded Activity

    Early Influences Of Obesity And Fat Patterning In Children:critical Periods, Environmental Determinants, And Socio-cultu

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,152,711.00
    Summary
    Childhood obesity is an escalating public health problem both internationally and within Australia. Rates of childhood obesity in Australia are at one of the highest amongst developed nations. 25% of Australian children are currently overweight or obese. Obesity is a strong risk factor for chronic disease. In children, obesity is of concern because it is highly likely to persist and, during childhood, contributes to serious physical and mental health problems. A quarter of Australian children ar .... Childhood obesity is an escalating public health problem both internationally and within Australia. Rates of childhood obesity in Australia are at one of the highest amongst developed nations. 25% of Australian children are currently overweight or obese. Obesity is a strong risk factor for chronic disease. In children, obesity is of concern because it is highly likely to persist and, during childhood, contributes to serious physical and mental health problems. A quarter of Australian children are now carrying excess body fat. Because of these factors, prevention of obesity is paramount because success of current treatment options is limited and does not last. Especially harmful forms of fatness may originate in early life - the tendency to store fat in the abdominal region and the tendency to accrete fat rather than muscle (at any body size). For this reason, the early life determinants of obesity deserve special attention, even in the presence of society-wide factors conducive to obesity. Professor Moore and a group of researchers from the University of Adelaide will test the proposition that pre-birth and infancy is a ‘critical period’ for the development of obesity. The group aims to investigate whether there is a distinct period in early life for acquiring the predisposition to harmful forms of fatness. The project also aims to identify practical opportunities for prevention, focusing on mothers and their infants.
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    Funded Activity

    Injecting Drug Users: Social Networks And Molecular Epidemiology Of The Hepatitis C Virus

    Funder
    National Health and Medical Research Council
    Funding Amount
    $543,868.00
    Summary
    The hepatitis C virus (HCV) continues to spread among injecting drug users (IDUs) in Australia at a very high rate, despite success in preventing the spread of HIV in the same groups; the complete reasons for this remain unclear. There is an urgent need for the HCV epidemic among IDUs to be contained. To do so, we must better understand the ways in which it is spreading among IDUs. Much is known about risk behaviours of individual IDUs and how they contribute to HCV transmission; much less is kn .... The hepatitis C virus (HCV) continues to spread among injecting drug users (IDUs) in Australia at a very high rate, despite success in preventing the spread of HIV in the same groups; the complete reasons for this remain unclear. There is an urgent need for the HCV epidemic among IDUs to be contained. To do so, we must better understand the ways in which it is spreading among IDUs. Much is known about risk behaviours of individual IDUs and how they contribute to HCV transmission; much less is known about how these behaviours are modified by the influence of the IDUs peer group, especially their immediate and intimate social networks. Despite its importance in influencing attitudes and behaviours, and therefore HCV transmission, this has never been studied in Australia, nor, in relation to HCV, in the world. We hope that by studying social and risk networks of IDUs we shall discover new ways in which control of the HCV epidemic can be achieved in Australia. We intend to do this among two groups of young IDUs, one of Vietnamese ethnicity, located in the one suburb of Melbourne. By using field techniques for gathering information (ethnography), and sophisticated analytic techniques to understand how these networks are formed and influence behaviours, we hope to be able to identify interventions which work at the level of the social group rather than the individual in bringing about the behaviour change necessary to prevent HCV transmission. To ensure that the risk networks we describe are as influential as they appear, and to discover more about the variability of HCV, we will also be investigating the relationship between the various strains of HCV in members of the IDU networks, particularly as another measure of the connectedness of networks and network members. This will be done using sophisticated genetic analysis of the HCV obtained from network members by blood test.
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    Enhancing Mental Health In Aboriginal People: Reducing Violence And Developing Resilience

    Funder
    National Health and Medical Research Council
    Funding Amount
    $1,771,151.00
    Summary
    This project aims to determine the best ways to improve the Social Emotional Well Being (SEWB) of the Aboriginal people of Broken Hill, Menindee and Wilcannia. This project will develop a culturally appropriate and evidenced based intervention to break the cycle of ongoing grief, mental illness, alcohol and other drugs and violence. The project will proceed in a number of interrelated phases including extensive community consultations and a baseline survey. The project will then implement and ev .... This project aims to determine the best ways to improve the Social Emotional Well Being (SEWB) of the Aboriginal people of Broken Hill, Menindee and Wilcannia. This project will develop a culturally appropriate and evidenced based intervention to break the cycle of ongoing grief, mental illness, alcohol and other drugs and violence. The project will proceed in a number of interrelated phases including extensive community consultations and a baseline survey. The project will then implement and evaluate an intervention program that provides a community and individual program that adopts evidence-based approaches and modifies them to be acceptable within Aboriginal communities. These interventions aim to break the cycle of violence and mental health problems by teaching adaptive skills to reduce violent behaviours and by providing mental health interventions that reduce disorders that contribute to violence.
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