Big-Picture Bioethics: policy-making and liberal democracy. We live an era of rapid growth in biotechnology generating new and difficult ethical questions that need to be tackled by bioethicists and politicians. This project goes beyond typical approaches in bioethics to explore the "big picture": how policies are generated in ethically-contentious domains. It is important to examine how the values of different stakeholders are reflected in such processes to ensure that they are in accordance wi ....Big-Picture Bioethics: policy-making and liberal democracy. We live an era of rapid growth in biotechnology generating new and difficult ethical questions that need to be tackled by bioethicists and politicians. This project goes beyond typical approaches in bioethics to explore the "big picture": how policies are generated in ethically-contentious domains. It is important to examine how the values of different stakeholders are reflected in such processes to ensure that they are in accordance with Australia's commitment to fostering a multicultural, pluralistic, democratic society. This project will produce practical recommendations for refining public consultation in healthcare policy-making through an examination of three relevant contentious case studies in Australia with comparison to Canada.Read moreRead less
Quantifying sea-level trends and extremes along Australia's coastal margin. Multi-decadal changes in sea-level, and sea-level extremes, cannot be well quantified along most global coastlines, including Australia's, because the high spatial variability of sea-level is under-sampled by the sparse set of long, high quality tide gauge records. Satellite altimetry provides an alternative data source with greater spatial sampling, yet experiences contamination from land within tens of kilometres from ....Quantifying sea-level trends and extremes along Australia's coastal margin. Multi-decadal changes in sea-level, and sea-level extremes, cannot be well quantified along most global coastlines, including Australia's, because the high spatial variability of sea-level is under-sampled by the sparse set of long, high quality tide gauge records. Satellite altimetry provides an alternative data source with greater spatial sampling, yet experiences contamination from land within tens of kilometres from the coast and also suffers from regionally correlated biases. This project proposes to address these problems through re-tracking radar altimetry waveforms to derive new data in the coastal margin, enabling the production of new inferences on sea-level change and extremes at dramatically improved spatial resolution around Australia.Read moreRead less
Unraveling ocean mixing and air-sea forcing along the Indo-Pacific exchange. This project aims to collect unprecedented observations and develop high resolution model simulations to examine changes in the Indonesian Throughflow (ITF) north of Australia. This project expects to develop new knowledge of ocean-atmosphere interactions along the path of the ITF from the Pacific to the Indian Ocean, which are the powerhouse that drives changes in winds and rainfall around Australia and the entire Indo ....Unraveling ocean mixing and air-sea forcing along the Indo-Pacific exchange. This project aims to collect unprecedented observations and develop high resolution model simulations to examine changes in the Indonesian Throughflow (ITF) north of Australia. This project expects to develop new knowledge of ocean-atmosphere interactions along the path of the ITF from the Pacific to the Indian Ocean, which are the powerhouse that drives changes in winds and rainfall around Australia and the entire Indo-Pacific region. Expected outcomes include a 1000-fold increase in the observations of mixing in the Indonesian seas and new understanding of the ocean-atmosphere processes that control water property change along the ITF. This should lead to strong improvement in the skill of climate forecast models in the Australian region.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Observations of remarkable eastward flows in the South Indian Ocean. The Indian Ocean drives much of the variability of Australian weather and rainfall and is rapidly evolving. Innovative new observations of remarkable eastward flows in the South Indian Ocean will be combined with models to understand these circulations in a region that has significant economic value for Australia.
How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at ....How do myelinating cells alter brain circuits to facilitate learning? This project aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process. This project will apply innovative technologies to understand how the nervous system remains adaptable throughout life. This new knowledge, of the cellular mechanisms that allow brain circuits to remain adaptable throughout life, may have application in the development of interventions aimed at improving educational outcomes or counteracting age-related memory decline. Potential future benefits include facilitating the development of drugs to circumvent memory loss resulting from brain diseases, and improving the design of neuromorphic hardware for computing.Read moreRead less
Equator to Pole: Reconstructing tropical and Antarctic climate variability over the last millennium and their impacts on southern Australian rainfall. Water resource management is one of the greatest challenges facing sustainable agriculture and urban populations across southern Australia. Key players driving catastrophic droughts in southern Australia are the tropical Indian Ocean Dipole and polar Southern Annual Mode climate systems, which affect moisture availability and transport pathways. T ....Equator to Pole: Reconstructing tropical and Antarctic climate variability over the last millennium and their impacts on southern Australian rainfall. Water resource management is one of the greatest challenges facing sustainable agriculture and urban populations across southern Australia. Key players driving catastrophic droughts in southern Australia are the tropical Indian Ocean Dipole and polar Southern Annual Mode climate systems, which affect moisture availability and transport pathways. This collaborative research project draws together a uniquely-skilled research team to develop targeted coral, ice and cave reconstructions of these climate systems and their impacts on Australian rainfall through the last millennium. This fundamental new knowledge of the drivers of Australian rainfall variability will aid improved predictability of future changes in our valuable water resources. Read moreRead less
Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data stream ....Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data streams. This project will use high-resolution global and regional ocean/sea-ice models to examine mechanisms for rapid warming of Antarctic continental shelf waters via both large-scale drivers and fine-scale processes, including mesoscale eddies, tide-topography interactions, and bottom boundary flows. This work will better constrain future rates of ice melt around Antarctica by providing vital knowledge of the ocean processes, dynamics, and feedbacks relating to warm water intrusion onto the Antarctic continental shelf.Read moreRead less
How topography brakes the Antarctic Circumpolar Current. This project aims to observe and simulate the mechanisms that slow the Antarctic Circumpolar Current. The Southern Ocean winds have increased over the last two decades while the transport of the world’s largest current remains steady or slightly decreasing. A possible explanation is negative feedback mechanisms between the winds and transport of the Antarctic Circumpolar Current. This project will observe how eddies carry momentum from the ....How topography brakes the Antarctic Circumpolar Current. This project aims to observe and simulate the mechanisms that slow the Antarctic Circumpolar Current. The Southern Ocean winds have increased over the last two decades while the transport of the world’s largest current remains steady or slightly decreasing. A possible explanation is negative feedback mechanisms between the winds and transport of the Antarctic Circumpolar Current. This project will observe how eddies carry momentum from the wind down to the sea floor and accelerate the deep currents that drag against the rough bottom to put the brakes on this current. Since this current affects Australian rainfall patterns and agricultural output, findings could inform public policy.Read moreRead less
Ancient Ecology: Changes in penguin diet over ~30,000 years in Antarctica. This project proposes the first direct study of ancient ecology using a combination of second-generation DNA sequencing and targeted gene recovery. The food web of the Antarctic Ocean is a classic textbook example of energy and nutrient cycling in the marine environment. Although a great deal is known about the current status of this food web, understanding how this complex set of predator / prey relationships have change ....Ancient Ecology: Changes in penguin diet over ~30,000 years in Antarctica. This project proposes the first direct study of ancient ecology using a combination of second-generation DNA sequencing and targeted gene recovery. The food web of the Antarctic Ocean is a classic textbook example of energy and nutrient cycling in the marine environment. Although a great deal is known about the current status of this food web, understanding how this complex set of predator / prey relationships have changed over long periods of time is vital to understanding the nature of the system itself. The project intends to track changes in the diet of Adélie penguins from serially preserved ancient fecal (guano) remains dating back approximately 30,000 years. These remains are known to contain microscopic remnants of penguin prey.Read moreRead less