Moving Research Into Practice – Using Process Evaluations Of Treatment Mechanisms To Inform The Implementation Of Evidence-based Healthcare
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Effective treatments must be integrated into clinical practice. But this process isn’t always efficient. One reason for this is a lack of understanding for how treatments work. My research will identify treatment mechanisms for chronic back pain (leading cause of disability world-wide) and use this information to integrate effective reatments into practice. I will work with experts from the Oxford Clinical Trials Unit, UK and apply this research to clinical health service units in Australia.
Targeting The Defective Airway Macrophage Function In Chronic Obstructive Pulmonary Disease (COPD): A New Therapeutic Approach
Funder
National Health and Medical Research Council
Funding Amount
$710,928.00
Summary
COPD/emphysema is smoking-related, incurable and a leading cause of death. New treatments are urgently needed. We have reported that airway phagocyte dysfunction and inflammation in COPD or smoke-exposed mice can be improved by novel treatments including lectins and macrolide antibiotics. We now show that these effects can be greatly improved by low-dose aspirin. We will further investigate these therapies and also novel antibiotics that have been modified to lose their anti-bacterial activity