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Novel Approaches For Targeted Sleep Apnoea Treatment And Management
Funder
National Health and Medical Research Council
Funding Amount
$2,090,576.00
Summary
>1million Australian adults have obstructive sleep apnoea (OSA). OSA has several causes. Untreated OSA is associated with major health consequences. <50% of OSA patients tolerate the main therapy, continuous positive airway pressure. New treatments are urgently required. This proposal aims to use and develop novel approaches to identify the causes of OSA on a per patient basis, improve current therapies and management approaches and test if new targeted therapies can be used to treat OSA.
Dangerous Dreams: The Next Era In Paediatric Sleep Research
Funder
National Health and Medical Research Council
Funding Amount
$2,238,220.00
Summary
The amount of time and the quality of our sleep affects every aspect of our health and well-being. The amount of time we sleep is maximal in infants and children because it is promotes normal brain development. Sleep problems affect nearly half of all children and adversely affect both learning and blood pressure. The proposed studies will identify and improve treatment of sleep problems to improve overall physical health and quality of life for these children and their families.
There are many challenges to the management of sleep disorders. There is mounting evidence that sleep problems promote impaired memory and thinking and ultimately dementia. My research will focus on improving detection and management of sleep disorders using cutting edge technologies in different patient groups with the aim of maximising brain health. This will be achieved by a range of new treatments including clinical trials, digital health approaches and new ways of improving deep sleep.
Suboptimal Sleep And Unhealthy Brain Ageing: Improving Outcomes Through Treatment
Funder
National Health and Medical Research Council
Funding Amount
$632,705.00
Summary
My research will address limitations in our understanding of the impact of sleep characteristics on memory and thinking abilities and biological markers of brain health in older adults, by; 1) exploring these relationships over time, and 2) enabling direct assessment of the effect of improved sleep on memory and thinking, and markers of brain health, following sleep-improvement therapy. My results will contribute to the development of strategies aimed at promoting healthy brain ageing.
The Kids Aren’t Alright: Preventing Depression In Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$600,715.00
Summary
Depression frequently emerges for the first-time during adolescence. This project examines ways to prevent depression in young people by: (i) partnering with schools to deliver broad universal programs to students through the education system, and (ii) treating sleep disturbance, a powerful but non-stigmatised risk factor for onset of depression. Findings from this research will inform innovative ways to address the depression crisis through the optimisation of prevention approaches.
Predicting, Diagnosing And Treating Synucleinopathies
Funder
National Health and Medical Research Council
Funding Amount
$3,738,220.00
Summary
Parkinson’s Disease and Lewy Body Dementia carry a high socioeconomic burden and there are currently no disease-modifying treatments. Existing symptomatic therapies focus on replacing neurotransmitters that are made by neurons that have mostly degenerated prior to clinical diagnosis, warranting a clear need to identify cases at a stage when they might benefit most from neuroprotective interventions, as well as improving symptomatic and developing disease modifying treatments.