Researching Effective Sleep Treatments (Project REST): A Partner-Assisted Intervention To Improve Adherence In Cognitive Behavioural Therapy For Insomnia
Funder
National Health and Medical Research Council
Funding Amount
$1,130,307.00
Summary
Insomnia is highly prevalent and predicts many other mental and physical problems. While very good behavioural treatments exist for insomnia, not everyone is able to comply with the difficult behaviour changes required to improve. Bed partners often influence sleep behaviours, and thus, can play a helpful role in the treatment of insomnia, if they are taught how. We will test the first intervention ever developed integrating the partner into insomnia treatment as a means of improving outcomes.
Optimising Early Interventions For Young People With Emerging Mood Disorder
Funder
National Health and Medical Research Council
Funding Amount
$2,653,052.00
Summary
One of our greatest health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood disorders, like major depression or bipolar disorder. This new Australian centre combines our national expertise and links it with research innovation and training in key European and North American centres. It tests the viability of selecting the best treatments for young people with mood disorders on the basis of novel genetic, neuropsychological, circadian, i ....One of our greatest health challenges is to develop highly-personalised interventions for teenagers and young adults with emerging mood disorders, like major depression or bipolar disorder. This new Australian centre combines our national expertise and links it with research innovation and training in key European and North American centres. It tests the viability of selecting the best treatments for young people with mood disorders on the basis of novel genetic, neuropsychological, circadian, imaging, immunological or clinical methods.Read moreRead less
Ascending Control Of Behavioural State And Cognition - Role Of Nucleus Incertus And Relaxin-3 Transmission
Funder
National Health and Medical Research Council
Funding Amount
$540,356.00
Summary
Mental illness and dementia are significant social and economic burdens worldwide and knowledge of their underlying causes and more effective therapies are required. Our research aims to use pre-clinical models to characterize a little studied neuronal network implicated in control of brain theta rhythm activity, which could lead to improved treatment of neuropsychiatric diseases such as anxiety and depression, and degenerative cognitive decline.
Ascending Neural Networks And Behavioural State Control
Funder
National Health and Medical Research Council
Funding Amount
$727,758.00
Summary
Our research aims to describe and understand newly identified nerve pathways or 'networks' in brain that control physiological homeostasis or balance and complex behaviours, including levels of arousal and motivation, sleep/wake patterns, learning and memory, and emotions such as fear and anxiety
Relaxin-3/RXFP3 Signalling And Regulation Of Affective Behaviour _ Studies In Normal/transgenic Mice
Funder
National Health and Medical Research Council
Funding Amount
$578,268.00
Summary
Mental illness is a significant social and economic burden worldwide and knowledge of the underlying causes and more effective therapies are required. Our research aims to use pre-clinical animal models to characterize a little studied brain neuronal network implicated in control of arousal and stress, which could lead to improved treatment of psychiatric disorders such as depression.
NeuroSleep: The Centre For Translational Sleep And Circadian Neurobiology
Funder
National Health and Medical Research Council
Funding Amount
$2,659,061.00
Summary
NeuroSleep, the Centre for Translational Sleep and Circadian Neurobiology, will foster innovative clinical research and translation to develop national capacity in understanding how sleep disorders and dysfunction of the body clock impact on health. The Centre will focus its activities on the two-way relationship between disrupted sleep and body clock systems and brain disorders. Our goal is to improve brain performance, workplace safety and health outcomes in patients with sleep and circadian d ....NeuroSleep, the Centre for Translational Sleep and Circadian Neurobiology, will foster innovative clinical research and translation to develop national capacity in understanding how sleep disorders and dysfunction of the body clock impact on health. The Centre will focus its activities on the two-way relationship between disrupted sleep and body clock systems and brain disorders. Our goal is to improve brain performance, workplace safety and health outcomes in patients with sleep and circadian dysfunction and in the general community.Read moreRead less
Obstructive Sleep Apnoea Phenotypes And Treatment In Quadriplegia
Funder
National Health and Medical Research Council
Funding Amount
$599,635.00
Summary
Losing function in your arms and legs after an injury (quadriplegia) is a catastrophic event. Quadriplegia also results in obstructive sleep apnoea; a condition where the throat closes repeatedly while asleep causing sleepiness, poor concentration and cardiovascular diseases like stroke. Despite most people with quadriplegia having this disease, the cause is unknown. This project will thoroughly investigate obstructive sleep apnoea causes in people with quadriplegia and test a possible treatment
The GOOD NIGHT Project: A Sleep Intervention To Prevent Depression And Improve Cardiac Health In Adolescence
Funder
National Health and Medical Research Council
Funding Amount
$902,741.00
Summary
There is a pressing need for effective approaches to preventing depression during adolescence. The primary aim of the project is to assess whether a brief sleep intervention can prevent depression in vulnerable adolescents. Given that sleep interventions also encourage daytime activity, which when combined with improved sleep has potential benefits for cardiovascular health, the secondary aim is to test whether the sleep intervention improves early indicators of cardiovascular risk.
Local Sleep In The Awake Brain: An Underlying Cause Of Neurobehavioural Deficits In Sleep Apnea?
Funder
National Health and Medical Research Council
Funding Amount
$582,330.00
Summary
Obstructive sleep apnea (OSA) is a common sleep disorder which significantly impacts daytime functioning leading to excessive sleepiness, and problems with attention and thinking. Currently, the causes for cognitive impairment in OSA (including attentional lapses and performance deficits) are poorly understood. In the awake state, groups of neurons can briefly go “offline” as they do in sleep. These periods of “local sleep” may explain impaired task performance in OSA.
The SNORE-ASA Study: A Study Of Neurocognitive Outcomes, Radiological And Retinal Effects Of Aspirin In Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$886,692.00
Summary
Sleep apnoea is very common in the elderly, but it is uncertain whether it leads to a decline in mental abilities as it can in the middle-aged. Apart from fatigue, sleep apnoea also causes mental decline by affecting brain blood supply. This may be preventable with aspirin. We will track 3,000 healthy elderly for 4 years, after testing for sleep apnoea. Half will take aspirin. We predict that mental ability will decline faster with sleep apnoea, and that aspirin will partly reverse this.