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Research Topic : Sleep disorders
Field of Research : Membrane Biology
Socio-Economic Objective : Nutrition
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  • Funded Activity

    Discovery Projects - Grant ID: DP0877897

    Funder
    Australian Research Council
    Funding Amount
    $300,000.00
    Summary
    Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutritio .... Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutrition. At a time where protein-rich diets are recommended to fight obesity and diabetes, it is important to understand the basis of protein absorption and metabolism. This project investigates the mechanism and mediators of amino acid absorption in kidney and intestine.
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    Funded Activity

    Discovery Projects - Grant ID: DP0212079

    Funder
    Australian Research Council
    Funding Amount
    $246,000.00
    Summary
    The role of omega-3 fatty acids in brain mechanisms that regulate water and salt balance. The ability of mammals to survive is heavily dependent upon their ability to maintain body fluid balance. This project aims to elucidate brain mechanisms for the behavioural regulation of water and salt balance, with specific investigation of the role of dietary fatty acids within these processes. It is hypothesised that omega-3 polyunsaturated fatty acids (PUFA) affect intake of water and salt by affecti .... The role of omega-3 fatty acids in brain mechanisms that regulate water and salt balance. The ability of mammals to survive is heavily dependent upon their ability to maintain body fluid balance. This project aims to elucidate brain mechanisms for the behavioural regulation of water and salt balance, with specific investigation of the role of dietary fatty acids within these processes. It is hypothesised that omega-3 polyunsaturated fatty acids (PUFA) affect intake of water and salt by affecting the sensitivity of various receptors, or the hormones used by this body system. Omega-3 PUFA are known to play a role in regulating genes, and therefore, may also affect the production of key proteins, such as receptors, hormones or enzymes involved in the regulation of salt and water intake.
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    Funded Activity

    Discovery Projects - Grant ID: DP0208282

    Funder
    Australian Research Council
    Funding Amount
    $141,000.00
    Summary
    Function and regulation of the Na+,K+-ATPase. The Na+,K+-ATPase is the major energy-consuming enzyme of animal cells. Its ion pumping is essential for numerous physiological functions (e.g. heart, kidney, brain). Molecular detail of its pumping mechanism is, however, lacking and its regulation is still unclear. We will use rapid reaction methods on purified enzyme in vitro to locate the rate-determining step of the enzyme cycle, determine its mechanism, investigate its regulation by sodium conce .... Function and regulation of the Na+,K+-ATPase. The Na+,K+-ATPase is the major energy-consuming enzyme of animal cells. Its ion pumping is essential for numerous physiological functions (e.g. heart, kidney, brain). Molecular detail of its pumping mechanism is, however, lacking and its regulation is still unclear. We will use rapid reaction methods on purified enzyme in vitro to locate the rate-determining step of the enzyme cycle, determine its mechanism, investigate its regulation by sodium concentration, phosphorylation and membrane composition, and isolate its charge-transporting steps. The results will have immediate impact on the understanding of the enzyme's mechanism, its metabolic control and its role in disease.
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    Showing 1-3 of 3 Funded Activites

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