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Three-dimensional structures, substrate specificities and catalytic mechanisms of polysaccharide synthases. Plant wall polysaccharides are extensively used for food and fibre, and are important dietary components in human nutrition. A precise knowledge of mechanisms used by plants to synthesize these polysaccharides is unavailable, but would reveal potential routes to manipulate their biosynthesis in important crop species. For example, the levels or structures of polysaccharides might be modif ....Three-dimensional structures, substrate specificities and catalytic mechanisms of polysaccharide synthases. Plant wall polysaccharides are extensively used for food and fibre, and are important dietary components in human nutrition. A precise knowledge of mechanisms used by plants to synthesize these polysaccharides is unavailable, but would reveal potential routes to manipulate their biosynthesis in important crop species. For example, the levels or structures of polysaccharides might be modified to improve their efficacy as anti-cancer agents in human diets, to enhance digestibility of animal stock feeds, or to synthesise pharmologically valuable compounds. Thus, economic, social and environmental benefits will flow to both producers and consumers. Read moreRead less
Activation mechanisms of store-operated calcium channels in liver cells. Currently, one of the most active areas of research in biology involves the molecular mechanisms that control the activity of cells. Defining these will provide a deeper understanding of normal function and disease, and provide potential therapeutic targets. This group has an international reputation for its work and it makes a major input to maintaining Australia as a significant contributor to this field. While its resea ....Activation mechanisms of store-operated calcium channels in liver cells. Currently, one of the most active areas of research in biology involves the molecular mechanisms that control the activity of cells. Defining these will provide a deeper understanding of normal function and disease, and provide potential therapeutic targets. This group has an international reputation for its work and it makes a major input to maintaining Australia as a significant contributor to this field. While its research has broad application in biology, its specific focus, calcium signalling in the liver, will provide the basis for understanding liver function and disease and, potentially, for developing new treatments for liver disease associated with abnormal calcium homeostasis.Read moreRead less