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Respiratory Phenotyping For New Targeted Approaches To Treat Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
>9% of Australians have obstructive sleep apnoea (OSA). OSA has several causes. Untreated OSA is associated with major health consequences. <50% of OSA patients tolerate the main therapy, continuous positive airway pressure. New treatments are urgently required. This proposal aims to use & develop novel approaches to identify the causes of OSA on a per patient basis, improve current therapies & test if new targeted therapies can be used to treat OSA in appropriately selected patients.
A-Prof Wheatley is a respiratory and sleep disorders physician investigating the pathogenesis, health consequences and management of sleep breathing disorders, including sleep apnoea and snoring.
Using Biomechanics To Prevent Injury And Treat Soft Tissue Disorders
Funder
National Health and Medical Research Council
Funding Amount
$705,501.00
Summary
In this fellowship, I will use biomechanical testing and analysis methods together with novel imaging methods to design and implement interventions to prevent injuries to children, and to improve treatment of obstructive sleep apnoea and complex disorders of the cerebrospinal fluid system.
Sleep Disorders And Human Health - Prevalence, Pathogenesis, Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
My primary research focus is to understand the mechanisms underlying sleep-related breathing disorders, such as obstructive sleep apnoea, and develop better ways to diagnose and treat them. I do this by undertaking university-based epidemiology studies in a large sample of community participants, by undertaking smaller hospital-based physiology studies and by working with US and Australian start-up companies to design and test new treatment for sleep disorders.
Allergies and chronic respiratory diseases are major causes of illness and death in Australia. Worryingly there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will investigate these questions and provide evidence to guide health policy and clinical management. As this program is built on state-of the-art methods and technology, these original Australian findings will be of great importance internationally.
My primary research focus is to understand the mechanisms underlying sleep-related breathing disorders, such as obstructive sleep apnoea, and develop better ways to diagnose and treat them. I also investigate physical therapies to improve the lives of people with chronic lung disease. Both sleep disorders and lung disease are extremely common in Australia. Improving the health and quality of life of these individuals has important personal benefit and social and economic benefits.
My work investigates the neural output to human inspiratory muscles and how it is related to mechanical effectiveness for breathing. The aim is to discover how this relationship can change with respiratory disorders such as chronic obstructive pulmonary disease and obstructive sleep apnoea. I also examine the changes in breathing muscle control in people with spinal cord injury. This work promises new understanding of the basic control of respiration and how it changes with disease.
Addressing Therapeutic Challenges In Sleep Disorders
Funder
National Health and Medical Research Council
Funding Amount
$851,980.00
Summary
The aim of this fellowship is to improve the health and well-being of Australians by reducing the burden of sleep and disorders that disrupt the body clock such as shift work. My program will involve different fields of research combining their efforts together to understand more about sleep apnea and insomnia, the two most common sleep disorders. By this strategy, better treatment for sleep disorders will be found with particular impact on our aging population
Sleep loss through sleep deprivation and sleep disorders is a common problem causing impaired brain and heart function as well as increasing human errors in the workplace. The fellowship will involve new research focusing on how better treatment of sleep problems can reduce blood pressure, vascular disease and road crashes. Cutting edge research facilities will help new studies into how jet lag and shiftwork impair health and how to counter this risk.
Human Movement Control: Basic And Applied Neurophysiology
Funder
National Health and Medical Research Council
Funding Amount
$948,684.00
Summary
My research targets mechanisms underlying human movement, ways in which they can be deranged, and ways in which interventions can diminish impairments. It focuses on gaps in understanding and in clinical practice. Work in our broad ‘Motor Impairment’ NHMRC Program underpin my research. It is supplemented by new work on respiratory neurophysiology which has already delivered basic and clinical insight into neural control of the main breathing muscles and more recently upper airway muscles.