Quantifying The Ventilatory Control Contribution To Obstructive Sleep Apnoea Using Clinical Polysomnography
Funder
National Health and Medical Research Council
Funding Amount
$196,995.00
Summary
Obstructive sleep apnoea is a highly prevalent condition with limited treatment options. New research shows that many patients have sleep apnoea because of a hypersensitive control of breathing (instability). Yet there is no way to measure instability and target it clinically. We aim to refine and apply a powerful new method to measuring breathing instability using a conventional sleep study, to allow treatments for sleep apnoea to be targeted at those patients who will respond most effectively.
What Role Do Cerebral Hypoxia And Sleep Disruption Play In The Neurocognitive Effects Of Paediatric Sleep Disordered Breathing?
Funder
National Health and Medical Research Council
Funding Amount
$558,957.00
Summary
Sleep disordered breathing (SDB) describes a spectrum of disorders caused by obstruction of the upper airway during sleep from simple primary snoring (PS) to obstructive sleep apnoea (OSA). Findings of our recently studies have provided strong evidence that all levels of SDB severity including PS are associated with neurocognitive and behavioural deficits. In this study we will investigate the mechanisms of which underpin these deficits.
Evaluating The Effect Of Morphine On Obstructive Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$534,303.00
Summary
Prescription opiate poisoning deaths have increased substantially in recent years which may be worsened by population increases in obesity and related obstructive sleep apnea. However, no proper clinical trial has ever investigated the effect of an opiate on obstructive sleep apnea, which is the aim of the proposed trial. The study will be important in understanding ways to reduce opiate realted deaths and may also provide insights into new treatment methods for snoring and sleep apnea.
Clarifying The Pathogenic Role Of Arousal-hyperventilation In Obstructive And Central Sleep Apnoea: Testing Fundamental Pathophysiological Mechanisms And A Strategic New Treatment
Funder
National Health and Medical Research Council
Funding Amount
$414,717.00
Summary
This project is designed to understand the mechanisms underpinning much more stable breathing during deep sleep in obstructive sleep apnoea (OSA). A newly developed analytical technique will be used to examine breathing effort changes across sleep, and interactions with respiratory-induced awakenings in OSA patients. In addition, a new treatment designed to stabilise breathing will be tested and refined towards a new treatment option for OSA and for central sleep apnoea.
Microvascular And Macrovascular Disease In Snoring And Obstructive Sleep Apnoea: A Mechanism For Increased Stroke Risk.
Funder
National Health and Medical Research Council
Funding Amount
$679,744.00
Summary
This project will address the important question of the vascular risk of stroke associated with snoring and obstructive sleep apnoea, by using retinal photography of the eye to directly visualise the vascular changes in the cerebral circulation. Retinal photography may provide a useful clinical tool to help reduce the risk of stroke in patients with snoring and sleep apnoea.
Clinical Outcomes, Safety And Incremental Cost Effectiveness Of Multi-level Airway Surgery In Patients With Moderate-severe Obstructive Sleep Apnea (OSA) Who Have Failed Medical Management
Funder
National Health and Medical Research Council
Funding Amount
$652,794.00
Summary
Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to ....Obstructive sleep apnoea (OSA) is a serious medical disorder with a high public health cost. OSA can be effectively treated but poor treatment compliance is a major clinical problem. As a consequence many OSA patients remain untreated, with significant implications for their long term health. New effective and safe therapies are needed. We believe that we will demonstrate a relatively straightforward, safe and effective surgical procedure for OSA after primary treatments fail. This will lead to improved patient outcomes.Read moreRead less
Novel Therapeutic Phenotyping For Sleep Apnoea - A Paradoxical Role For Sedatives
Funder
National Health and Medical Research Council
Funding Amount
$639,168.00
Summary
Sleeping pill (sedative) use has risen dramatically. Sedatives may worsen a common breathing condition called obstructive sleep apnoea (OSA). Accordingly, their use has been discouraged in OSA. However, recent studies indicate that certain sedatives may actually reduce OSA severity in some patients. By studying the effects of common sedatives on OSA and breathing, this proposal aims to explain these apparent paradoxical responses and ultimately provide a new treatment approach for OSA.
The SNORE-ASA Study: A Study Of Neurocognitive Outcomes, Radiological And Retinal Effects Of Aspirin In Sleep Apnoea
Funder
National Health and Medical Research Council
Funding Amount
$886,692.00
Summary
Sleep apnoea is very common in the elderly, but it is uncertain whether it leads to a decline in mental abilities as it can in the middle-aged. Apart from fatigue, sleep apnoea also causes mental decline by affecting brain blood supply. This may be preventable with aspirin. We will track 3,000 healthy elderly for 4 years, after testing for sleep apnoea. Half will take aspirin. We predict that mental ability will decline faster with sleep apnoea, and that aspirin will partly reverse this.
Predicting Treatment Response To Mandibular Advancement Splints: A Novel Biomechanical Imaging Method
Funder
National Health and Medical Research Council
Funding Amount
$689,062.00
Summary
Mandibular advancement splints are an alternative to continuous positive airway pressure for patients with Obstructive Sleep Apnoea (OSA). However, they are effective for only about half of OSA patients, and it is not currently possible to predict who will benefit. This project will explore a new magnetic resonance imaging method to see if it can predict who will respond to mandibular advancement splint therapy.
The Evolution Of Childhood Obesity And Its Relationship To Adult Sleep Disordered Breathing
Funder
National Health and Medical Research Council
Funding Amount
$870,842.00
Summary
This project will characterise Obstructive Sleep Apnoea (OSA) in early adulthood. It will assess the prevalence of OSA in a well characterised cohort (the Raine Cohort), representative of the population of young adults in Western Australia. It will define the clinical picture and risk factors associated with abnormal breathing during sleep and will use the extensive longitudinal data collected from 18 weeks gestation until 23 years of age to quantify early life developmental and environmental pr ....This project will characterise Obstructive Sleep Apnoea (OSA) in early adulthood. It will assess the prevalence of OSA in a well characterised cohort (the Raine Cohort), representative of the population of young adults in Western Australia. It will define the clinical picture and risk factors associated with abnormal breathing during sleep and will use the extensive longitudinal data collected from 18 weeks gestation until 23 years of age to quantify early life developmental and environmental predictors that can inform public health policy.Read moreRead less