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Cerebral Circulation In Sleep - Physiology & Pathophysiology
Funder
National Health and Medical Research Council
Funding Amount
$779,650.00
Summary
Prolonged, repetitive episodes of obstructed breathing during sleep (known as obstructive sleep apnoea syndrome or OSA) is a common medical problem that afflicts both adults and children. As many as 200,000 Australian adults and 100,000 children are affected. OSA has major medical consequences, amongst the most serious being cardiovascular disease and stroke. This experimental study investigates the blood flow to the brain and heart in normal sleep, and in sleep disrupted by OSA, as many of the ....Prolonged, repetitive episodes of obstructed breathing during sleep (known as obstructive sleep apnoea syndrome or OSA) is a common medical problem that afflicts both adults and children. As many as 200,000 Australian adults and 100,000 children are affected. OSA has major medical consequences, amongst the most serious being cardiovascular disease and stroke. This experimental study investigates the blood flow to the brain and heart in normal sleep, and in sleep disrupted by OSA, as many of the problems associated with OSA may have their origin in disturbance of blood flow to the brain and heart.Read moreRead less
Foetal Determinants Of Sleep Disordered Breathing In Infants
Funder
National Health and Medical Research Council
Funding Amount
$174,691.00
Summary
Obstructive sleep apnea (OSA) has been identified and recorded in infants, however the factors that lead to the development of OSA and its prevalence in infants is unknown. We have recorded OSA in some infants and we demonstrated that the severity of apnea was at its peak at approximately 2 months of age and then resolved by 1 year. We hypothesised that these infants possibly had a maturational delay of breathing control during sleep. This project is designed to examine the development and preva ....Obstructive sleep apnea (OSA) has been identified and recorded in infants, however the factors that lead to the development of OSA and its prevalence in infants is unknown. We have recorded OSA in some infants and we demonstrated that the severity of apnea was at its peak at approximately 2 months of age and then resolved by 1 year. We hypothesised that these infants possibly had a maturational delay of breathing control during sleep. This project is designed to examine the development and prevalence of sleep and breathing disorders in infants. The prenatal factors that possibly influence development of sleep and breathing disorders in infants, in particular, the effects of maternal smoking will be determined. Pregnant women will be recruited for the study during their third trimester. The foetal movements, foetal breathing movements, heart rate and sleep state will be monitored continuously overnight in the patients home between 32 and 36 weeks gestation using a newly developed foetal movement monitor. The infants will be subsequently studied using overnight polysomnography at 2 months of age to assess their breathing, sleep patterns, arousal behaviour, and the presence and severity of central and obstructive apnea. A group from these infants will be selected and studied longitudinally to examine the development of sleep and breathing disorders more closely. These infants will undergo overnight sleep studies during the first week of life, then at 2 and 6 months of age. A detailed medical history will also be collected regarding the pregnancy, the perinatal history of the infant, exposure to cigarette smoke during pregnancy and postnatally, and the medical history of other family members. We will examine the quality and quantity of foetal movements and its association with the development of OSA. The occurrence of sleep and breathing disorders in the infants will be correlated with the foetal behaviour and, the prenatal and postnatal factors.Read moreRead less