We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Thermo-electro-chemo-mechanical properties of biological systems. The proposal is aimed at developing a new theoretical framework for piezoelectric biological materials and structures, through theoretical analysis, computation and numerical simulations, as well as experimental investigations, to produce high-reliability, high-performance hydrogel components and smart soft tissue structures. It is envisaged that successful outcomes of this program will give the Australian biological industry a te ....Thermo-electro-chemo-mechanical properties of biological systems. The proposal is aimed at developing a new theoretical framework for piezoelectric biological materials and structures, through theoretical analysis, computation and numerical simulations, as well as experimental investigations, to produce high-reliability, high-performance hydrogel components and smart soft tissue structures. It is envisaged that successful outcomes of this program will give the Australian biological industry a technology edge over their competitors and provide easy-to-use guidelines for the design of smart biological systems.Read moreRead less
Structures and properties of tissue engineering matrices for cartilage and bone: Imaging, visualising and modelling tissue/scaffold constructs in 3D. Tissue engineering of bone and cartilage has the potential to lower costs and improve outcomes. The first stage requires the design of porous 3D scaffolds. To date they have been found less than ideal for clinical applications. Our ability to design and optimise scaffolds has been ad hoc, as local structure and properties have not been measurable ....Structures and properties of tissue engineering matrices for cartilage and bone: Imaging, visualising and modelling tissue/scaffold constructs in 3D. Tissue engineering of bone and cartilage has the potential to lower costs and improve outcomes. The first stage requires the design of porous 3D scaffolds. To date they have been found less than ideal for clinical applications. Our ability to design and optimise scaffolds has been ad hoc, as local structure and properties have not been measurable during tissue growth and repair. In this proposal, an interdisciplinary group from three universities will utilise microCT imaging, visualisation and numerical modelling to determine these structures and properties. This will provide an invaluable understanding for the further development of tissue engineering scaffolds.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561186
Funder
Australian Research Council
Funding Amount
$447,967.00
Summary
Surface Mechanical Property Analysis Facility. The aim of this proposal is to develop a facility for the mechanical properties analysis of material surfaces. The facility will enable an understanding of the performance of materials in a wide range of contact and abrasion situations and in very small volumes such as thin films and components of multiphase composites. The unique features of the proposed facility are that it is capable of analysis down to exceptionally low sub-micron length scale, ....Surface Mechanical Property Analysis Facility. The aim of this proposal is to develop a facility for the mechanical properties analysis of material surfaces. The facility will enable an understanding of the performance of materials in a wide range of contact and abrasion situations and in very small volumes such as thin films and components of multiphase composites. The unique features of the proposed facility are that it is capable of analysis down to exceptionally low sub-micron length scale, under multiple forms of loading and over a range of temperatures. It is applicable to the design of abrasion resistant materials, characterisation of very thin surface films for applications such as microelectronics and biomedical implants and design of advanced composites.Read moreRead less
Optimising lasers for ablation of structurally complex solid non-metals. This project aims to take the latest developments in fibre laser technology to create a new ablation system for precision cutting and reshaping of structurally complex non-metal materials. Fibre lasers provide high quality beams, high average power, and precise pulse timing. Guided by the composition of the material and its response to incident mid-infrared light, the project will create a tailored laser beam to provide ac ....Optimising lasers for ablation of structurally complex solid non-metals. This project aims to take the latest developments in fibre laser technology to create a new ablation system for precision cutting and reshaping of structurally complex non-metal materials. Fibre lasers provide high quality beams, high average power, and precise pulse timing. Guided by the composition of the material and its response to incident mid-infrared light, the project will create a tailored laser beam to provide accurate and high-rate ablation. The expected outcomes include minimal damage to the surrounding area and a level of precision not possible with any mechanical alternative. The project will provide long term benefits to the aerospace and healthcare industries and, be a boost to Australia’s manufacturing sector.Read moreRead less