Development And Application Of Novel Bioinformatics Approaches To Identify Pathogenetic Mechanisms Underlying Migraine
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Migraine is a public health problem. Although GWAS lead to robust findings, the mechanisms and therapeutic strategies are unknown. This is caused by limited sample size hampering obtaining large number of SNPs by GWAS. Integrating priori knowledge with bioinformatics studies is promising to discover hidden SNPs. Here, I will develop a novel approach to find novel genetic risk loci and genes by integrating comprehensive knowledge on SNPs and genes with GWAS instead of increasing sample.
Investigation Of Dysfunction Of OPRS1, A Novel Gene Implicated In Neurodegeneration
Funder
National Health and Medical Research Council
Funding Amount
$535,471.00
Summary
A new gene has recently been discovered to play an important role in various brain and nerve degeneration disorders, including frontotemporal dementia and motor neuron disease. The aim of this project is to discover what biological processes are involved when this gene malfunctions, as this will provide knowledge important for development of new treatments for the many people worldwide affected with these disorders.