ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a com ....Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a competitive advantage for various sections of the Australian industry, including telecommunications, biotechnology and finance. The project will enable Australian researchers to continue to work at the forefront of this fast moving and exciting area of international research.Read moreRead less
Rare Event Simulation with Heavy Tails. The project provides a rigorous way to enhance our understanding of the mechanisms that bring about catastrophic rare events such as urban flooding, electricity shortages and financial bankrupcy. Australia is at the forefront of exciting recent developments in rare event simulation. The advancement of the knowledge in this area will generate a competitive advantage for various sections of the Australian industry, including the areas of industrial reliabili ....Rare Event Simulation with Heavy Tails. The project provides a rigorous way to enhance our understanding of the mechanisms that bring about catastrophic rare events such as urban flooding, electricity shortages and financial bankrupcy. Australia is at the forefront of exciting recent developments in rare event simulation. The advancement of the knowledge in this area will generate a competitive advantage for various sections of the Australian industry, including the areas of industrial reliability, finance and insurance, were accurate simulation techniques are becoming increasingly important.Read moreRead less
Special Research Initiatives - Grant ID: SR0354793
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a mul ....A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a multidisciplinary spectrum. This will drive an integrated and accelerated program of discovery and technological development, enhancing Australia's leadership in this crucial field and helping to highlight new biotechnology opportunities and capture social and economic benefits for the nation. Read moreRead less
Computer simulation to study emergence of material texture in the Earth and Plate Tectonics. Plate tectonics has played a crucial role in the evolution and dynamics of the earth impacting on the diversity of life, mineralisation, and crustal dynamics. Despite its significance, how and under what conditions material texture and plate tectonics emerge from a proto-planet is not well understood. New computational methodologies to simulate the evolution of the plate-mantle system will be used to stu ....Computer simulation to study emergence of material texture in the Earth and Plate Tectonics. Plate tectonics has played a crucial role in the evolution and dynamics of the earth impacting on the diversity of life, mineralisation, and crustal dynamics. Despite its significance, how and under what conditions material texture and plate tectonics emerge from a proto-planet is not well understood. New computational methodologies to simulate the evolution of the plate-mantle system will be used to study how the upper mantle emerges as a thermo-mechanically distinct boundary layer, how this emergent structure relates to anisotropy in the upper mantle, and how it is affected by cross-scale effects controlling fault zone behaviour and crustal dynamics.Read moreRead less
Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Stochastic modelling of spatiotemporal nonlinear diffusion processes with multifractal characteristics. This research is relevant to solute transport and plume evolution in heterogeneous media. Detailed modelling of these processes is computer-intensive, while the diffusion models of this project offer a more economical alternative. Our study will also benefit the research on the salinity problem. Excessive demand for irrigation water to support agricultural production has stretched freshwater a ....Stochastic modelling of spatiotemporal nonlinear diffusion processes with multifractal characteristics. This research is relevant to solute transport and plume evolution in heterogeneous media. Detailed modelling of these processes is computer-intensive, while the diffusion models of this project offer a more economical alternative. Our study will also benefit the research on the salinity problem. Excessive demand for irrigation water to support agricultural production has stretched freshwater aquifers beyond their long-term yield. Large areas of land have been lost to saltwater intrusion. This proposal will provide suitable tools to predict the level and movement of saltwater in the aquifers. Application to the development of management strategies would bring direct benefit to coastal areas where salinity is a sustainability issue.Read moreRead less
Stochastic modelling and analysis of spatio-temporal processes with fractal characteristics. Interest has grown in recent years on the derivation of fractal models to represent certain physical phenomena such as diffusion and transport in porous media, oceanic and atmospheric turbulence, climatology, etc. This project focuses on the phenomenon of diffusion on domains with multifractal geometry. Recent advances in harmonic analysis on fractals and our own development of fractional generalized ran ....Stochastic modelling and analysis of spatio-temporal processes with fractal characteristics. Interest has grown in recent years on the derivation of fractal models to represent certain physical phenomena such as diffusion and transport in porous media, oceanic and atmospheric turbulence, climatology, etc. This project focuses on the phenomenon of diffusion on domains with multifractal geometry. Recent advances in harmonic analysis on fractals and our own development of fractional generalized random fields allow us to formulate a comprehensive program to tackle some key problems including modeling, processing and statistical estimation of fractional diffusion. Advances made in this program will in turn benefit the developments in related scientific fields.Read moreRead less
The improvement of climate change investigations by developing and applying innovative evolutionary subset time series modelling using semi-parametric sparse-patterned approaches. With an estimated US$6.98 trillion loss indicated in the Stern review, severe climate change will make world climate conditions harsher and more likely include large natural climate disasters. The health of the Australian economy is critically dependent on decisions of environmental managers. However, most problems of ....The improvement of climate change investigations by developing and applying innovative evolutionary subset time series modelling using semi-parametric sparse-patterned approaches. With an estimated US$6.98 trillion loss indicated in the Stern review, severe climate change will make world climate conditions harsher and more likely include large natural climate disasters. The health of the Australian economy is critically dependent on decisions of environmental managers. However, most problems of complexity arising in climate change involve issues on which we do not possess a deep understanding. This project draws upon a set of inter-disciplinary concepts and models centred in neural networks that enable us to advance our understanding of complexity, leading to superior quantitative tools and models to allow for improved environmental decision-making.
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A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can ....A multi-scale approach for modelling coupled transport in heterogeneous and anisotropic porous media. Mathematical Sciences foster interdisciplinary collaboration and underpin fundamental understanding of significant national/international research priorities in science and technology. This world-class team will advance knowledge in modelling complex systems ensuring the competitiveness of Australian research in this important field. A key outcome is a multi-scale computational strategy that can be used by engineers in Australia and France to simulate transport phenomena in porous media, which have significant environmental impact. The research will lead to publications in scientific journals and communications at national/international conferences. Research training of postdocs and PhD students is another excellent outcome of the project.Read moreRead less