Reforming of Liquid Hydrocarbon Fuels for Application in Solid Oxide Fuel Cells Technology. The project will aim at developing a fuel processing system for solid oxide fuel cells which will have the advantages of being fuel flexible through the conversion of liquid fuels (gasoline, LPG, diesel) for application in small to medium stationary power generation systems. This investigation will also generate fundamental information and understanding concerning the catalytic reforming of liquid hydroca ....Reforming of Liquid Hydrocarbon Fuels for Application in Solid Oxide Fuel Cells Technology. The project will aim at developing a fuel processing system for solid oxide fuel cells which will have the advantages of being fuel flexible through the conversion of liquid fuels (gasoline, LPG, diesel) for application in small to medium stationary power generation systems. This investigation will also generate fundamental information and understanding concerning the catalytic reforming of liquid hydrocarbon fuels to produce adequate feeds for SOFCs. These distributed energy devices are of high efficiency and with a novel technology the industrial partner will aim to offer products with high value propositions in the critical areas of price, reliability and service.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100118
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Nuclear magnetic resonance spectroscopy facilities for the Sydney region. The determination of molecular structure is crucial in the chemical and biomolecular sciences, leading to the development of new drugs and other types of molecules and providing an understanding of how molecules interact with each other. The requested equipment will provide the ability for researchers in the Sydney region to advance our knowledge at this fundamental level by expanding the number and types of experiments th ....Nuclear magnetic resonance spectroscopy facilities for the Sydney region. The determination of molecular structure is crucial in the chemical and biomolecular sciences, leading to the development of new drugs and other types of molecules and providing an understanding of how molecules interact with each other. The requested equipment will provide the ability for researchers in the Sydney region to advance our knowledge at this fundamental level by expanding the number and types of experiments that can be performed.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100135
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Federated single crystal X-ray structural analysis facility. X-ray crystallography is the most widely applied method for the determination of three-dimensional molecular structures. These structures range in size from small systems such as materials and pharmaceuticals through to large biological structures such as proteins. This application will provide a multidisciplinary facility covering the structural characterisation needs of chemistry, pharmacy, biology, and medicine. This will position l ....Federated single crystal X-ray structural analysis facility. X-ray crystallography is the most widely applied method for the determination of three-dimensional molecular structures. These structures range in size from small systems such as materials and pharmaceuticals through to large biological structures such as proteins. This application will provide a multidisciplinary facility covering the structural characterisation needs of chemistry, pharmacy, biology, and medicine. This will position local universities for key scientific breakthroughs that benefit the Australian community by providing improved healthcare technologies, and processes. Furthermore, access to this world-class facility will provide state-of-the-art training for undergraduate, postgraduate and postdoctoral researchers.Read moreRead less
The role of low-energy excited states in solar-energy capture. This project aims to determine the nature and role of the lowest-energy excited states in most natural photosynthetic reaction centres and light-harvesting complexes. The lowest-energy states of bacterial reaction centres are critical to function and are used as a paradigm in artificial organic solar-energy capture, but for most photosystems their nature remains unknown. The project aims to answer the critical question of why they do ....The role of low-energy excited states in solar-energy capture. This project aims to determine the nature and role of the lowest-energy excited states in most natural photosynthetic reaction centres and light-harvesting complexes. The lowest-energy states of bacterial reaction centres are critical to function and are used as a paradigm in artificial organic solar-energy capture, but for most photosystems their nature remains unknown. The project aims to answer the critical question of why they do not actually prevent function. It is expected that both the outcomes obtained and techniques developed will be directly relevant to solar-energy device design. The project will apply five existing, complimentary and purposely built spectrometers as well as quantum electronic and nuclear simulation techniques to identify and characterise three key systems.Read moreRead less
Structural and functional investigations of the human transcription machinery by ion mobility-mass spectrometry. This project will apply emerging mass spectrometric technologies to gain previously inaccessible insight into human transcription factor proteins. This will reveal new avenues for intervention in human disease states related to aberrant gene expression, while developing innovative methods for the study of complex protein assemblies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100163
Funder
Australian Research Council
Funding Amount
$860,365.00
Summary
Structure Determination Pipeline Capabilities for South Australia. This project aims to complete a high-throughput, automated pipeline for biomolecule crystallisation and provide enhanced X-ray structure determination capabilities for all sample types. This is critical because X-ray crystallography remains the primary technique for achieving molecular level insights to help solve cutting-edge problems in life, materials, chemical, earth and agricultural sciences. The diverse researcher community ....Structure Determination Pipeline Capabilities for South Australia. This project aims to complete a high-throughput, automated pipeline for biomolecule crystallisation and provide enhanced X-ray structure determination capabilities for all sample types. This is critical because X-ray crystallography remains the primary technique for achieving molecular level insights to help solve cutting-edge problems in life, materials, chemical, earth and agricultural sciences. The diverse researcher community in South Australia will benefit from a more rapid structure determination pipeline from molecular sample to structure. The infrastructure will drive research findings in energy and resources, food, soil and water security, advanced manufacturing and life sciences and lead to economic and technological impacts.Read moreRead less
Elucidation of structure-function relationships in biological systems utilising advanced electron spin resonance. The human growth hormone receptor and mammalian P450 enzymes are implicated in numerous human disorders and the key to treatment is the rational design and delivery of drugs. This project will require a comprehensive understanding of the biological structure-function relationship which we will acquire using high-resolution electron spin resonance spectroscopy.
Unravelling the structural complexity of ancient Australian arthropod venoms. Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of ....Unravelling the structural complexity of ancient Australian arthropod venoms. Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of toxins in the venom of two ancient Australian arthropods (spiders and centipedes). This will provide a comprehensive overview of these venoms and provide opportunities in engineering new classes of venom based drugs and insecticides. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100144
Funder
Australian Research Council
Funding Amount
$1,225,000.00
Summary
High Performance Single Crystal X-ray Diffraction Facility. This project aims to establish an advanced multidisciplinary facility for the structural characterisation of chemical and biological molecules. Through providing a broad suite of advanced capabilities, including measurement under a range of conditions and rapid crystal screening, the project expects to greatly accelerate research efforts across a wide spectrum of the molecular sciences. Expected outcomes include detailed understandings ....High Performance Single Crystal X-ray Diffraction Facility. This project aims to establish an advanced multidisciplinary facility for the structural characterisation of chemical and biological molecules. Through providing a broad suite of advanced capabilities, including measurement under a range of conditions and rapid crystal screening, the project expects to greatly accelerate research efforts across a wide spectrum of the molecular sciences. Expected outcomes include detailed understandings of the structures and functions of an array of scientifically and technologically important systems, spanning materials, proteins and pharmaceuticals. This should provide significant benefits, both in advancing the understanding of these systems and in spurring commercial development and application.Read moreRead less
Automated structural analysis of proteins by nuclear magnetic resonance (ASAP-NMR): a leap forward in structural studies of proteins using NMR spectroscopy. Proteins form the machinery that makes life possible, and this research will revolutionise study of their three-dimensional structure by making the process faster and cheaper. This approach will be applied to study proteins isolated from animal venoms in order to identify and develop novel pharmaceuticals and bio-insecticides.