Complex Architecture and Convergent Design. After breaking the design code for Gaudí's Sagrada Família Church in 1979, completing the still unfinished church has required Mark Burry to pioneer groundbreaking architectural and construction design methodologies and practices. His current work is on the computer modelling and dynamic simulation of complex design and construction problems, and methods for multi-disciplinary and distributed team collaboration. This work has high impact industry appli ....Complex Architecture and Convergent Design. After breaking the design code for Gaudí's Sagrada Família Church in 1979, completing the still unfinished church has required Mark Burry to pioneer groundbreaking architectural and construction design methodologies and practices. His current work is on the computer modelling and dynamic simulation of complex design and construction problems, and methods for multi-disciplinary and distributed team collaboration. This work has high impact industry applications. At the intersection of so many fields of industrial research, Mark Burry's work acts as a catalyst and accelerator for technology transfer and innovation across the architectural, design and construction industries.Read moreRead less
Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Nonparametric Statistical Methods -- New Directions, Theory and Applications. The research program will take Australia to the forefront of contemporary work in nonparametric statistics, and assist greatly in the training of a new generation of Australian statistical scientists. It will contribute significantly to restoring the health of this strategically important field, in Australian universities and in the nation more generally. The projects outlined in the proposal address problems arising ....Nonparametric Statistical Methods -- New Directions, Theory and Applications. The research program will take Australia to the forefront of contemporary work in nonparametric statistics, and assist greatly in the training of a new generation of Australian statistical scientists. It will contribute significantly to restoring the health of this strategically important field, in Australian universities and in the nation more generally. The projects outlined in the proposal address problems arising in astronomy, economics, engineering, defence, health and image analysis, but the potential areas of impact are broader even than this. This diversity illustrates the extraordinary potential, and strategic significance, of statistics to Australia. Read moreRead less
Molecular control of apoptosis and protein homeostasis. A million cells are produced every second by cell division. At the same time a million cells commit suicide by a process called apoptosis. When cells fail to die when they should they can develop into cancers. In heart attacks, stroke and neurodegenerative diseases, many cells appear to activate their self destruct mechanism to die unnecessarily. Drugs that can cause cancer cells to kill themselves, or drugs that prevent cells dying when th ....Molecular control of apoptosis and protein homeostasis. A million cells are produced every second by cell division. At the same time a million cells commit suicide by a process called apoptosis. When cells fail to die when they should they can develop into cancers. In heart attacks, stroke and neurodegenerative diseases, many cells appear to activate their self destruct mechanism to die unnecessarily. Drugs that can cause cancer cells to kill themselves, or drugs that prevent cells dying when they shouldn't, would make a major impact on many important diseases. Understanding the molecular mechanisms of cell death is the first step towards developing these drugs.Read moreRead less
Ecology and evolution in dynamic systems: a new approach to conserving Australian biodiversity. Australia has different ecosystems and different species than the rest of the world, and we need a different approach to conserve and manage our unique animals. This project will develop a new, specifically Australian-oriented approach to conservation biology.
Television in the post-broadcast era: the role of old and new media in the formation of national communities. This Federation Fellowship program will examine the place of television in a range of national locations during the post-broadcast era, addressing its socio-cultural function for the citizen as well as considering the competing or complementary roles played by new forms of online journalism. The program will provide a unique international comparative overview of contemporary media system ....Television in the post-broadcast era: the role of old and new media in the formation of national communities. This Federation Fellowship program will examine the place of television in a range of national locations during the post-broadcast era, addressing its socio-cultural function for the citizen as well as considering the competing or complementary roles played by new forms of online journalism. The program will provide a unique international comparative overview of contemporary media systems in the midst of dramatic change. The expertise, critical mass and findings developed within the program will equip Australia to better understand and manage the complex role the media plays in socio-cultural change, while providing cutting edge policy advice to government and industry.Read moreRead less
Precision Pulsar Timing and its Applications. The rapidly rotating pulsars known as millisecond pulsars have period stabilities which rival that of the best terrestrial clocks. Observations of many millisecond pulsars spread across the sky should allow detection of the gravitational-wave background - likely to be the first direct detection of gravity waves. It will also enable establishment of a long-term time standard which is independent of and probably superior to that derived from terrestria ....Precision Pulsar Timing and its Applications. The rapidly rotating pulsars known as millisecond pulsars have period stabilities which rival that of the best terrestrial clocks. Observations of many millisecond pulsars spread across the sky should allow detection of the gravitational-wave background - likely to be the first direct detection of gravity waves. It will also enable establishment of a long-term time standard which is independent of and probably superior to that derived from terrestrial clocks. New analysis techniques and establishment of an international observing network will be required. Investigation and application of techniques for overcoming radio interference will be an important part of the project.Read moreRead less
A clearer view of the evolving universe. The two complementary research objectives of this proposal are (i) a basic research program to understand star formation in galaxies through a study of the correlation betwen far infrared and radio continuum emission and (ii) a strategic research program to develop interference mitigation techniques to enable the next generation of radio telescopes which will study star formation in the early Universe. This programme of research innovation in radio astron ....A clearer view of the evolving universe. The two complementary research objectives of this proposal are (i) a basic research program to understand star formation in galaxies through a study of the correlation betwen far infrared and radio continuum emission and (ii) a strategic research program to develop interference mitigation techniques to enable the next generation of radio telescopes which will study star formation in the early Universe. This programme of research innovation in radio astronomy will also promote the broad aims of furthering opportunities for Australian participation in international science and of gaining insight into ways in which Australia can exploit its niche advantages in the global economy.Read moreRead less
Science for resilience of coral reef systems. Hughes's Fellowship has enormous capacity to provide economic, cultural, environmental and social benefits for Australia. The coral reefs of Australia, particularly the Great Barrier Reef, Ningaloo Reef, and Lord Howe Island World Heritage Area are Australian national icons, of great economic, social, and aesthetic value to this country. Hughes and his collaborators in a newly-created ARC Centre of Excellence will be the premier providers of the scie ....Science for resilience of coral reef systems. Hughes's Fellowship has enormous capacity to provide economic, cultural, environmental and social benefits for Australia. The coral reefs of Australia, particularly the Great Barrier Reef, Ningaloo Reef, and Lord Howe Island World Heritage Area are Australian national icons, of great economic, social, and aesthetic value to this country. Hughes and his collaborators in a newly-created ARC Centre of Excellence will be the premier providers of the scientific expertise that underpins the management of Australian reefs, which is vital for the sustainable use of biodiversity goods and services (e.g. by the tourist industry, fisheries, and recreational users).Read moreRead less
Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific commun ....Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific community and will be disseminated back to the scientific community, to the humanities and to the Australian public. The project will bring to Australia the strengths of the applicant's existing collaborations with leading research centres in this field in the USA, UK and Canada.Read moreRead less