Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. T ....Target Of Rapamycin control of nutrient uptake. This project aims to study nutrient uptake in eukaryotes. It is expected to generate new knowledge of critical and conserved features of environmental and Target Of Rapamycin (TOR)-mediated control of nutrient uptake, specifically endocytosis, building on novel preliminary data that identifies novel TOR control points. The expected outcomes include new insights into mechanisms controlling nutrient uptake and fostering institutional collaboration. This knowledge is highly relevant to any industry or research project utilising living organisms, as nutrient availability supports survival, cell growth and proliferation.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
Development and evaulation of novel foods enriched with very long chain omega-3 fatty acids. This project is a collaborative effort between Meadow Lea Foods, Clover Corporation, and the Universities of Wollongong and Western Australia. The aims are 1) to develop a range of functional foods enriched with omega-3 from tuna oil; 2) to see whether the recommended omega-3 intake, currently nor met by most Australians, can be achieved by including these foods in the diet; 3) to evaluate sensory and he ....Development and evaulation of novel foods enriched with very long chain omega-3 fatty acids. This project is a collaborative effort between Meadow Lea Foods, Clover Corporation, and the Universities of Wollongong and Western Australia. The aims are 1) to develop a range of functional foods enriched with omega-3 from tuna oil; 2) to see whether the recommended omega-3 intake, currently nor met by most Australians, can be achieved by including these foods in the diet; 3) to evaluate sensory and health attributes and other factors that may impact on consumer acceptability hence market potential of the food range. There is little evidence of the feasibility let alone health and social benefits of utilising novel foods to meet the dietary omega-3 recommendation. We expect a) to show how consumers could benefit by using a range of such foods in their customary diet; b) to critically set this achievement within the context of current social trends in food product development. Read moreRead less
Development and application of an index for substantiating health benefits of omega-3 enriched foods. A cost-effective means of substantiating health claims for omega-3 (w3) rich functional foods is needed to fully exploit growing consumer demand for these products. In a two-stage approach, cardiovascular and anti-inflammatory benefits of w3 will be assessed in human dietary trials; improvements of health status in response to graded doses of w3 supplements will be correlated with docosahexaenoi ....Development and application of an index for substantiating health benefits of omega-3 enriched foods. A cost-effective means of substantiating health claims for omega-3 (w3) rich functional foods is needed to fully exploit growing consumer demand for these products. In a two-stage approach, cardiovascular and anti-inflammatory benefits of w3 will be assessed in human dietary trials; improvements of health status in response to graded doses of w3 supplements will be correlated with docosahexaenoic acid (DHA) levels in erythrocytes (DHA Index). Simple bioavailability trials can then be used to determine the intakes of foods required to attain the DHA Index, thus confirming their potential to deliver specified health benefits. Initial trials will support health claims for w3 rich fresh pork and processed pork products.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347447
Funder
Australian Research Council
Funding Amount
$180,000.00
Summary
Human Physiology & Nutrition Research Facility for assessment of metabolic status and vascular function. A state of the art Human Physiology and Nutrition Facility will be established in South Australia to examine vascular and metabolic biomarkers. With integrated ambulatory blood pressure and arterial compliance monitoring, ultrasound evaluation of endothelial function and DEXA measurement of body composition, it will enable: 1. multi-centre evaluation of dietary and exercise strategies to impr ....Human Physiology & Nutrition Research Facility for assessment of metabolic status and vascular function. A state of the art Human Physiology and Nutrition Facility will be established in South Australia to examine vascular and metabolic biomarkers. With integrated ambulatory blood pressure and arterial compliance monitoring, ultrasound evaluation of endothelial function and DEXA measurement of body composition, it will enable: 1. multi-centre evaluation of dietary and exercise strategies to improve cardiovascular and metabolic fitness; 2. substantiation of metabolic and cardiovascular health benefits of functional foods and bioactive nutrients; 3. evaluation of biomarkers and their programming in early development; 4. further development of assessment technology. Its establishment will enhance food industry collaboration in nutrition research.Read moreRead less