Low-energy electro-photonics: novel materials, devices and systems. This project aims to develop low-power technologies for programming and tuning photonic integrated circuits (PICs). By replacing thermal tuning, the project will reduce power consumption from watts to milliwatts, which also eliminates the thermal crosstalk that limits the complexity of today's PICs. The expected outcome will be the basis for a generic field-programmable photonic chip, which can be used to rapidly prototype desig ....Low-energy electro-photonics: novel materials, devices and systems. This project aims to develop low-power technologies for programming and tuning photonic integrated circuits (PICs). By replacing thermal tuning, the project will reduce power consumption from watts to milliwatts, which also eliminates the thermal crosstalk that limits the complexity of today's PICs. The expected outcome will be the basis for a generic field-programmable photonic chip, which can be used to rapidly prototype designs for production as full custom chips as part of a new Australian industry capability. The expected benefits will be a faster innovation cycle, greater adoption of photonic technologies, and support of research into, for example, neuromorphic optical processing, and advanced communications and sensing systems.Read moreRead less
Statistical Methods of Model Fitting and Segmentation in Computer Vision. Electronic sensors such as cameras and lasers can provide a rich source of information about the position, shape, and motion of objects around us. However, to extract this information in a reliable, automatic, and accurate way requires a sophisticated statistical theory of the process. Example applications include: video surveillance (better automatic detection of moving people and vehicles and of characterising what those ....Statistical Methods of Model Fitting and Segmentation in Computer Vision. Electronic sensors such as cameras and lasers can provide a rich source of information about the position, shape, and motion of objects around us. However, to extract this information in a reliable, automatic, and accurate way requires a sophisticated statistical theory of the process. Example applications include: video surveillance (better automatic detection of moving people and vehicles and of characterising what those people and vehicles are doing), industrial prototyping and inspection (measuring the size and shape of objects), urban planning (laser scanning streetscapes to create computer models of cities), entertainment industry (movie special effects and games), etc. Read moreRead less
EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
XML Views of Relational Databases: Semantics and Update Problems. XML is the standard for representing, publishing and exchanging data over the Internet and relational database is the dominant technology for data management. Updating XML views over relational data is fundamental to bring these two technologies together to serve Internet-based applications. Australia has been a leading country in both developing and applying internet technologies. The theoretic outcomes of this project will contr ....XML Views of Relational Databases: Semantics and Update Problems. XML is the standard for representing, publishing and exchanging data over the Internet and relational database is the dominant technology for data management. Updating XML views over relational data is fundamental to bring these two technologies together to serve Internet-based applications. Australia has been a leading country in both developing and applying internet technologies. The theoretic outcomes of this project will contribute to the advance in database and web research communities and establish us as an internationally leading group in this research area. The technological outcomes will help organisations in Australia effectively and efficiently conduct e-Business on the Internet. Read moreRead less
Investigation of the fundamental roles of class Ib MHC (major histocompatibility complex) molecules in immunity. The proposed research program, using laboratory-based and synchrotron-based radiation, will provide insight into the roles of a poorly understood class of immune molecules. This will improve our understanding of the regulation of immunity, and the knowledge gained will increase Australia's international research profile.
Improved image analysis: maximised statistical use of geometry/shape constraints. This project will improve image analysis to apply such applications as 3D street-scape reconstruction, synthetic inserts into video for special effects, autonomous navigation, and scene understanding. It will do so by maximally exploiting the geometry of planar surfaces (e.g. walls) and straight lines and other simple geometric shapes.
Visual tracking of multiple objects: A stochastic geometrical approach. Reliable real-time visual multiple-object tracking techniques will open up new applications that enhance the quality of life such as driving safety, traffic monitoring, home security, security and surveillance of public facilities. These new applications have huge commercial potentials, and the technology developed from this project will provide the catalyst for vibrant new industries to grow. In addition, the expertise deve ....Visual tracking of multiple objects: A stochastic geometrical approach. Reliable real-time visual multiple-object tracking techniques will open up new applications that enhance the quality of life such as driving safety, traffic monitoring, home security, security and surveillance of public facilities. These new applications have huge commercial potentials, and the technology developed from this project will provide the catalyst for vibrant new industries to grow. In addition, the expertise developed from the project will provide a competitive edge for Australian industries in aerospace, oceanography, robotics, remote sensing, and biomedical engineering. Read moreRead less
Regulation of autophagy dependent cell and tissue deletion. This project aims to elucidate novel mechanisms that regulate autophagy-depdendent cell death during animal development. It will combine the power of Drosophila genetics with multidisciplinary approaches, such as proteomics, bioinformatics and cell biology. Given the conserved nature of autophagy the oucomes will provide highly topical and exciting new knowledge of broad biological significance. The project will help establishing inter ....Regulation of autophagy dependent cell and tissue deletion. This project aims to elucidate novel mechanisms that regulate autophagy-depdendent cell death during animal development. It will combine the power of Drosophila genetics with multidisciplinary approaches, such as proteomics, bioinformatics and cell biology. Given the conserved nature of autophagy the oucomes will provide highly topical and exciting new knowledge of broad biological significance. The project will help establishing international collaborations, enhancing Australia’s competitiveness and reputation in an important area of research, and provide training of HDR students in skills across a range of areas. In the long-term the research findings may translate into improved agriculture, food production and human health outcomes.Read moreRead less
Transcription factor nuclear residency as a driver of gene expression. Persistently active proteins can stay in the nucleus to drive cell growth and prevent cell death. This project will define how one specific active protein can remain in the nucleus and regulate gene expression through the action of unique ribonucleic acid (RNA) molecules. The results will enable persistent gene activation to be manipulated in cancer.