In Vivo Responses To Pathogen-derived Mediators Of Acute Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$94,250.00
Summary
Sepsis causes large numbers of deaths worldwide. It is not known why some patients tolerate an infection and fully recover, while other patients with an equivalent infection are highly vulnerable to severe illness and death from sepsis. Heart failure is a common underlying condition in sepsis. This research will focus on how an infection can cause sudden cardiac death. It will have implications for care of patients with severe infection and also sudden infant death syndrome.
The Role Of Cell Death Pathways In Inflammation And Pathogen Infection
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
Cell death and inflammation are essential for protection against pathogen infection but can also cause human diseases. Inflammation caused by the IL-1? protein has been implicated in diseases such as type II diabetes, arthritis and cancer. This project aims to elucidate how IL-1? protein activity is regulated at the molecular level. It also seeks to understand how the pathogen responsible for Legionnaires’ disease manipulates cell death to allow for successful invasion of the human host.
The Emergence Of Dead Enzymes As Signal Transducers And Therapeutic Targets
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
The cells within our bodies are constantly being replenished by new cells. Removal of old cells is typically fast and without fanfare. However, in some cases, cell death can be used to evoke an inflammatory response. My work examines the molecular details of how this happens and how we might advance our knowledge to develop novel drugs to prevent inflammatory diseases, such as Crohn's disease and psoriasis.