Systems modelling of the cardiac fibroblast. The cardiac fibroblast is a specialised cell in the heart. New evidence shows that this cell type is central to heart function, but relatively little is known about how and why. This project will develop mathematical modelling to characterise how the cardiac fibroblast regulates the functioning of the adult heart.
Discovery Early Career Researcher Award - Grant ID: DE140101268
Funder
Australian Research Council
Funding Amount
$386,820.00
Summary
Stochastic mathematical modelling of the Wnt signalling pathway. The Wnt signalling pathway is pivotal in multicellular organisms, regulating cellular processes such as proliferation, apoptosis and migration. Faulty Wnt signalling is associated with degenerative diseases, developmental disorders and cancers and is therefore a potential target for therapeutic drugs. This project will perform a stochastic spatial simulation of the Wnt signalling pathway which will be matched to experimental data. ....Stochastic mathematical modelling of the Wnt signalling pathway. The Wnt signalling pathway is pivotal in multicellular organisms, regulating cellular processes such as proliferation, apoptosis and migration. Faulty Wnt signalling is associated with degenerative diseases, developmental disorders and cancers and is therefore a potential target for therapeutic drugs. This project will perform a stochastic spatial simulation of the Wnt signalling pathway which will be matched to experimental data. The model will be extended to integrate with the cell cycle. Increased proliferation in tumours has been linked to mutations in Wnt components. Using the extended model, the effect of Wnt-targeting therapeutic cancer drugs on cancer cell proliferation rates will be predicted and compared to experiments.Read moreRead less
Modelling and estimation methods for discrete multi-dimensional systems. Multi-dimensional signal processing plays a role in a variety of application areas, ranging from remote sensing for environmental monitoring and geological mapping, to medical imaging and the automatic control of industrial processes. The success of the project will provide mathematical tools for the advancement of the state-of-the-art in these broad areas.
Modelling, Analysis and Synthesis Tools for Multi-Dimensional Signal Processing Systems. Multi-dimensional signal processing plays a role in a variety of application areas, ranging from remote sensing for environmental monitoring and geological mapping, to medical imaging and the automatic control of industrial processes. The success of this project will provide mathematical tools for the advancement of the state-of-the-art in these broad areas.
Fundamental Studies in System Identification. To operate a dynamic system such as a chemical process plant or an economy one needs two things; the equations describing the system; a way of regulating the system to provide desired outcomes. System identification provides the first; control engineering design provides the second. This proposal addresses three important problems in system identification and control. Firstly since the equations can never be known precisely we aim to determine what i ....Fundamental Studies in System Identification. To operate a dynamic system such as a chemical process plant or an economy one needs two things; the equations describing the system; a way of regulating the system to provide desired outcomes. System identification provides the first; control engineering design provides the second. This proposal addresses three important problems in system identification and control. Firstly since the equations can never be known precisely we aim to determine what is the best one can do? Secondly to provide then tight error bounds for the control design;
thirdly to develop new methods for some hitherto unresolved problems in system identification.Read moreRead less
Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This resear ....Joint System Identification for Point Processes and Time-series. In various application areas such as neurophysiology, earthquake modeling, price spikes in electricity markets, the data of interest are point processes (aka sequences of events) or combinations of point processes and analog signals. To understand the underlying subject of interest we need to be able to extract the maximum information from these observation sequences. The current tools for doing this are very limited. This research program will develop the complex signal processing and system methodology needed to create a suitable tool set.Read moreRead less
Feedback Architectures with Parallel Communication Channels. Feedback control is an enabling, though often hidden, technology. For example, without control loops, cars, mining and manufacturing plants cannot operate in an efficient and safe manner. To reduce costs, there has been a trend to use general purpose communication systems, such as WiFi, for feedback control. These communication systems have only limited capacity and reliability. This can lead to performance degradation and system failu ....Feedback Architectures with Parallel Communication Channels. Feedback control is an enabling, though often hidden, technology. For example, without control loops, cars, mining and manufacturing plants cannot operate in an efficient and safe manner. To reduce costs, there has been a trend to use general purpose communication systems, such as WiFi, for feedback control. These communication systems have only limited capacity and reliability. This can lead to performance degradation and system failure. The current project aims at proposing novel robust networked control system architectures. Our results will be useful to allow industries to use standard communications technology for control, thus, alleviating costs associated with developing dedicated application specific communication infrastructure.Read moreRead less
Development of Identification Methods for Nonlinear Dynamical Systems. It is widely recognized that nonlinear systems theory will mark a new era of control science in the coming decade, and will be used in various types of applications. Driven by such immense opportunities and needs, identification of nonlinear systems is emerging as a vital, active area of research. The success of this project will enhance Australia's leading role in the international control community. The training of the post ....Development of Identification Methods for Nonlinear Dynamical Systems. It is widely recognized that nonlinear systems theory will mark a new era of control science in the coming decade, and will be used in various types of applications. Driven by such immense opportunities and needs, identification of nonlinear systems is emerging as a vital, active area of research. The success of this project will enhance Australia's leading role in the international control community. The training of the postdoctoral research associates will generate the expertise needed to maintain the involvement of the coming generation in cutting-edge technological advancement. The project will strengthen research activities in Australia through strong international collaborations.Read moreRead less
An Investigation into Performance Limitation of Wireless Networked Feedback Systems. Recent technological advances in information technology have begun to drive controls research in a direction that seeks to merge communication networks, control design, and computing power. Investigation of the constraints, limitations, and tradeoffs in design of wireless networked control systems is of intrinsic scientific interest and broad engineering impact. The success of this project will enrich Australia' ....An Investigation into Performance Limitation of Wireless Networked Feedback Systems. Recent technological advances in information technology have begun to drive controls research in a direction that seeks to merge communication networks, control design, and computing power. Investigation of the constraints, limitations, and tradeoffs in design of wireless networked control systems is of intrinsic scientific interest and broad engineering impact. The success of this project will enrich Australia's leading role in the international control community. The training of the postdoctoral research associates will generate the expertise needed to maintain the coming generation involved in cutting-edge technological advancement. The project will strengthen research activities in Australia through strong international collaborations.Read moreRead less
Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of internation ....Communication and information storage mechanisms in complex dynamical brain networks. Recordings of electrical activity in the brain often cycle repetitively. The aim of this research is to explain how these brain rhythms assist the brain to coordinate simultaneous activity in several regions. Australian socioeconomic benefits include: (i) contributions to the knowledge base of theoretical neuroscience, enhancing Australia's reputation for cutting-edge research; (ii) strengthening of international collaborations with Europe and Japan; (iii) outcomes will ultimately impact on improved medical bionics and future interfaces between brain activity and machines or computers; and (iv) commercialization and technology transfer opportunities, via the transfer of results to biologically inspired engineering.Read moreRead less