Effects Of Circadian Disruption And Sleep Deprivation In Respiratory Disorders
Funder
National Health and Medical Research Council
Funding Amount
$408,000.00
Summary
This project aims to determine the impact of reduced sleep hours and jet lag-sleep time shift in two very common breathing disorders; sleep apnea (snoring sickness) and asthma. We will also make measurements in healthy normal people as well. Reduced sleep hours are common in many sections of society due to a number of factors, including increased work hours, overtime, shiftwork, medical conditions (sleep and other medical disorders), caring for a new baby, and other family and social demands. In ....This project aims to determine the impact of reduced sleep hours and jet lag-sleep time shift in two very common breathing disorders; sleep apnea (snoring sickness) and asthma. We will also make measurements in healthy normal people as well. Reduced sleep hours are common in many sections of society due to a number of factors, including increased work hours, overtime, shiftwork, medical conditions (sleep and other medical disorders), caring for a new baby, and other family and social demands. In addition, body clock disruption due to shiftwork, transmeridien travel, circadian based sleep disorders and other factors that shift the timing of normal sleep-wake behaviour is also very prevalent in today's society. The effects of reduced sleep hours and jet lag-sleep time shift effect a number of body systems but have only been studied to a limited extent in the breathing system. Jet lag-sleep time shift changes are result of changes to the body clock rhythms - these rhythms effect coordinate activities of essentially all bodily functions, vigilance and thinking, heart, breathing, hormones, bowel function and the immune system that fights off infection and cancer. Together, this body clock system and sleep coordinate the majority of systems of the body and brain. This project will address a number of questions including whether reduced sleep hours worsen brain function in sleep apnea or whether shifting sleep (jet lag effect) can worsen airway function and increase risk of asthma. We will use two types of study - simulated jet lag and reduced sleep hours under complete laboratory supervision to test our theoriesRead moreRead less
A Case-control Study Of Environment And Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$808,948.00
Summary
Breast cancer is the most common cancer in Australian women and there have been a number of recent events which have raised public concern that occupational exposures are contributing to the increasing occurrence of this cancer. In this study, we will investigate occupational causes of breast cancer, particularly shift work, industrial solvent use and combustion products. We will compare occupations of 1000 women with breast cancer and 2000 women without cancer.
Inter-rater Reliability And Predictive Validity Of A New Functional Capacity Evaluation For Chronic Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$105,794.00
Summary
Back pain costs the Australian community tens of billions of dollars. Back pain is one of the main causes of work injury and lost time from work. The longer a person is off work, the harder it is to get them back to work. Workers' compensation systems around Australia aim at getting the injured worker with back pain back to work as soon as possible. One of the difficulties in this process is determining what the person with back pain can physically do in the workplace. An evaluation technique, c ....Back pain costs the Australian community tens of billions of dollars. Back pain is one of the main causes of work injury and lost time from work. The longer a person is off work, the harder it is to get them back to work. Workers' compensation systems around Australia aim at getting the injured worker with back pain back to work as soon as possible. One of the difficulties in this process is determining what the person with back pain can physically do in the workplace. An evaluation technique, called functional capacity evaluation (known as FCE), is one method used to find out what the person with back pain physically can and cannot do. In a FCE, a trained health professional such as an occupational therapist, observes the person performing a range of physical activities like the ones he or she may have to perform in a job. The therapist closely observes the person performing activities such as lifting, carrying, kneeling, crouching, balancing, and walking and notes any limitations in the person's ability to complete the activities. The therapist makes comments about what difficulties the person may have on the job and recommendations about how these could be reduced or eliminated. The information gained from these evaluations can be valuable for the treating doctor in deciding whether the person is ready to go back to work and what duties the person can and cannot do on the job. Because of such value they provide, FCE is commonly used in rehabilitation programs endorsed by workers' compensation systems around Australia. This widespread use and endorsement of FCE occurs despite limited research on the soundness of the ratings made from these evaluations. There is a need to see whether recommendations made from FCEs are consistent between therapists (i.e. reliable) and to see if the FCE accurately predicts the person's physical capacity for work. This research will examine these issues with injured workers with back pain.Read moreRead less
The Impact Of Electronic Medication Administration Records (e-MAR) On Medication Administration Safety And Nurses' Work
Funder
National Health and Medical Research Council
Funding Amount
$735,675.00
Summary
The demands on health systems, both nationally and internationally, are growing, exacerbated by an ageing population and health workforce shortages. The incorporation of information technology into new health care delivery models promises both improvements in the safety and efficiency of care delivery. Medication errors are one of the most significant safety issues for health care systems. Medication management occupies a significant amount of nurses' time, and is also fraught with error potenti ....The demands on health systems, both nationally and internationally, are growing, exacerbated by an ageing population and health workforce shortages. The incorporation of information technology into new health care delivery models promises both improvements in the safety and efficiency of care delivery. Medication errors are one of the most significant safety issues for health care systems. Medication management occupies a significant amount of nurses' time, and is also fraught with error potential. One-third of all medication errors that cause patient harm arise from medication administration errors (MAEs). Electronic medication administration records (e-MARs) provide the potential to make the administration of medications safer for patients by reducing error rates, and also by allowing nurses to more efficiently manage medication tasks. However there is very limited research from Australia or overseas which has examined whether they computerised system work and in fact reduce error rates or save nurses time. In this project we will conduct prospective, controlled observational studies to determine the effectiveness of an electronic medication administration record (e-MAR) to reduce MAEs and the amount of time nurses spend in the medication administration process. The project will apply innovative data collection tools using PDA software purpose-built for these studies which have undergone extensive pilot testing in clinical settings. The results will have important implications for hospitals across Australia and internationally as they consider the implementation of e-MARs. This research will provide the first comprehensive data of medication administration errors in Australia against which future preventative error strategies can be evaluated. The results will provide the evidence needed to develop recommendations about how to reduce MAEs and improve the design of e-MARs.Read moreRead less
Depression And Anxiety In Working Adults: The Costs And Outcomes Of Working While Ill
Funder
National Health and Medical Research Council
Funding Amount
$137,292.00
Summary
Depressive and anxiety disorders are common in the working population and costly. Individuals can continue working while ill or take an absence from work. This study will evaluate the economic cost and health outcomes of these two scenarios, using existing and published data to develop descriptive models. We consider who pays and who benefits from the perspective of the individual, their employer and society, to inform policy making, management practices, and clinical care.
Psychosocial Disability And Return To Work In Younger Stroke Survivors
Funder
National Health and Medical Research Council
Funding Amount
$511,216.00
Summary
Each year about 12,000 Australians of working age survive a stroke. These younger survivors have responsibility for generating an income or providing care for families and state that their main objective is to return to work for financial reasons and to help rebuild confidence and independence. This observational 3 year study will determine thefactors are associated with returning to work, improving the wellbeing of thousands of stroke survivors and their families using multivariate regression.
Clinical Efficacy And Physiological Mechanisms Of Nerve And Tendon Gliding Exercises For Carpal Tunnel Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$370,068.00
Summary
Compression of one of the major nerves at the wrist (carpal tunnel syndrome) is a very common condition that significantly impacts on the well-being of the patient. To date, there is no good evidence that traditionally advocated interventions are effective in the long term. This project will evaluate the effects of a novel, active treatment strategy and will investigate the underlying mechanisms that may be associated with exercises that aim to mobilise the nerve and tendons at the wrist.
Biomechanical And Physiological Responses Of Children And Young Adults To Different Computer Workstations
Funder
National Health and Medical Research Council
Funding Amount
$207,352.00
Summary
Computer use is increasing with 95% of Australian primary school children now using computers. Two out of three children and three out of four adult workers report pain associated with computer use. This has lead to concerns that increased computer use may be responsible for an increase in musculoskeletal disorders in young people. Little is known about the physical consequences of children's use of computers. The information we have on adult use is now out of date because of changes to computer ....Computer use is increasing with 95% of Australian primary school children now using computers. Two out of three children and three out of four adult workers report pain associated with computer use. This has lead to concerns that increased computer use may be responsible for an increase in musculoskeletal disorders in young people. Little is known about the physical consequences of children's use of computers. The information we have on adult use is now out of date because of changes to computer technology and how computers are used. It is therefore not possible to provide evidence-based recommendations for safe use of computers by young people. Critical gaps in our knowledge include the appropriate desk design and computer display position. The proposed studies will use recent advances in biomechanical and physiological measurement and modelling of musculoskeletal stress to evaluate a range of desk designs and computer display positions for young adults, preadolescentchilden and early school age children. The outcomes will include the first detailed description of the physical stresses of computer use by children and preliminary guidelines for workstation design.Read moreRead less
Randomised Study Of Radiotherapy (RT) Or ChemoRT To Palliate Symptoms Of Advanced Oesophageal Cancer (OC)
Funder
National Health and Medical Research Council
Funding Amount
$236,375.00
Summary
Cancer of the oesophagus (gullet) causes swallowing problems (dysphagia) by narrowing the gullet and harming food movement to the stomach. >90% of patients with oesophageal cancer (OC) have dysphagia. OC is common, representing >1% of all cancer diagnoses, but is rarely curable, >80% of patients having disease beyond the oesophagus at presentation. Overall survival is thus poor with <10% of patients alive at 3 years. Most have disease obstructing the gullet and thus most patients suf ....Cancer of the oesophagus (gullet) causes swallowing problems (dysphagia) by narrowing the gullet and harming food movement to the stomach. >90% of patients with oesophageal cancer (OC) have dysphagia. OC is common, representing >1% of all cancer diagnoses, but is rarely curable, >80% of patients having disease beyond the oesophagus at presentation. Overall survival is thus poor with <10% of patients alive at 3 years. Most have disease obstructing the gullet and thus most patients suffer dysphagia as they come to terms with dying. This affects both the patient's ability to maintain nutrition and impinges on all areas of quality of life (QoL). Enjoying food is a pleasure of life and an inability to swallow food, water and saliva causes a significant loss of personal self esteem. Relief of dysphagia is the highest priority for treatment. This must be balanced against toxicity of treatment. It is surprising that patients and their doctors must consider this with very little scientific data to help their decisions. The trial uses a simple 2 arm randomisation, radiotherapy (RT) 35Gy in 15 fractions, versus the same with chemotherapy (Cisplatin and Fluorouracil). Both the RT schedule and chemotherapy are commonly used in Australia for this and other cancers. This is the first trial in the world to prospectively assess RT and the first to compare the effect of adding chemotherapy. The trial will:- 1. establish a new method of assessing dysphagia and QoL in all patients with OC using a set of specific questions(EORTC-QLQ-C30+oesophageal module). 2. quantify response and toxicity of a common RT schedule. 3. evaluate the extra benefit and toxicities of chemotherapy. 4. evaluate patient and tumour factors determining outlook, and response to treatment. 5. provide a bench mark for trials of new chemotherapy agents and different RT schedules. The trial will guide management and provide information for incurable patients even if both arms are similar in their effect.Read moreRead less